CHEMICAL CONSTITUENTS AND TYROSINASE INHIBITORY ACTIVITY OF AQUEOUS FRACTION OF THE LEAVES OF MORUS ALBA LINN. FROM VIETNAMAbstract
The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study, we have isolated three compounds (LC1-3) by chromatographic methods from the mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as Kaempferol-3, 7-di-O-α-L-rhamnopyranoside (LC1), 7, 4’- dihydroxy-5, 3’- dimethoxyflavone (LC2), (S)-5, 5’, 7-trihydroxy-2’, 4’-dimethoxy-6-methylflavanone (LC3). Their structures were elucidated by spectroscopic methods, including MS and NMR. Compound LC3 was isolated from mulberry leaves for the first time. These compounds were evaluated the tyrosinase inhibitory activity in-vitro. Our data showed that compound LC3 has potential tyrosinase inhibitory effects with IC50 values of 15.48 ± 2.96 µg/mL.
L. V. Duc *, T. B. Thanh, H. L. T. Thu and B. N. Van
School of Medicine and Pharmacy, Vietnam National University, No.144 Xuan Thuy Street, Cau Giay, Hanoi, Vietnam.
01 March 2018
24 March 2018
30 March 2018
01 July 2018