Posted by admin on Jul 31, 2018 in |
The research in alternative medicine and the need for the plant-based medicines that affect the ‘mind’ is developing day to day. The aim of the present study was to explore Leptadenia reticulata (roots), Mimusops elengi (bark) and Evolvulus alsinoides (Whole plant) using different animal models (conditional avoidance response, hole board test, open field test), anticonvulsant (MES induced convulsions), myorelaxant action (rotarod) and hypnotic property (Phenobarbital-induced sleeping) in suitable animal models. Diazepam (2 mg/kg, p.o), Phenytoin (25 mg/kg, p.o) and Phenobarbital sodium (50 mg/kg, i.p) were used as the standard drugs, and the acetone and ethanolic extract were 200 mg/kg, p.o Selected as per OECD guidelines. Results suggested that the extracts produced significant (p<0.001) anti-anxiety, myorelaxant and hypnotic action, but not significant anticonvulsant effect (p<0.05). Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed CNS effects of the acetone and ethanolic extract of the selected...
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Posted by admin on Jul 31, 2018 in |
Santalum rubrum is medicinally important plant belonging to the family of Santalaceae. It has been used extensively by Ayurvedic practitioner and is also reported to contain anthraquinones and flavonoids, these constituents are well documented to possess anti-inflammatory activity. The fatty acid compositions of the petroleum ether extract of seeds of this plant were determined by Gas Chromatography-Mass Spectrophotometer. 7 compounds were identified from the extract of seeds (99.97 %), and they are palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid, behenic acid and lignoceric acid of methyl ester. Among all fatty acids of linoleic acid showed the highest concentration...
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Posted by admin on Jul 31, 2018 in |
Purpose: The aim of the present study was to investigate the wound healing activity of the selected Indian medicinal plants Terminalia chebula, Terminalia bellarica, Ficus racemosa, Piper nigrum, Zingiber officinalis. Method: Excision and incision models for diabetes-induced rats at specified varying doses. Result: The plants showed a definite, positive effect on wound healing. Conclusion: The efficacy of these plants in wound healing may be due to its action on antioxidant enzymes, thereby justifying the traditional...
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Posted by admin on Jul 31, 2018 in |
ABSTRACT: Context: Syzygium cumini (L.) Skeels (Myrtaceae) is popularly known to have various pharmacological and traditional uses. Before this study, there were no claims reporting its potential use for dengue by increasing platelet and leukocyte levels. Objectives: The effects of the methanolic extract of S. cumini leaves on the platelet and leukocyte levels were evaluated in Sprague-Dawley rats at doses 400 mg/kg and 800 mg/kg body weight. Methodology: The bioassay utilized 24 rats that were divided into four groups (n = 6) where hydroxyurea was used to induce depletion of platelet and leukocyte levels in all groups. After induction, oral treatment of methanolic extract was given daily to the treatment groups for six days. The platelet and leukocyte counts were measured before induction to get the baseline, after induction, and at the 1st, 3rd, and 6th day of treatment. High-performance liquid chromatography (HPLC) analysis was also conducted to identify the phenolic compounds present in the extract. Results: Results revealed that the methanolic extract of S. cumini caused an increase...
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Posted by admin on Jul 31, 2018 in |
As a source of remedies, medicinal plants are widely used as alternative medicines for the treatment or prevention of many diseases. Ficus hispida is traditionally used for treating diarrhoea, wounds, pain, inflammation, diabetes, fever, and neurological disorders. To evaluate the qualitative phytochemical constituents and antidiarrhoeal activity of methanolic extract of Ficus hispida leaves the present study was designed. Phytochemical constituents and anti-diarrhoeal activities were determined and assessed by various tests such as Molisch’s test, Fehling test, Mayer’s test, frothing test, FeCl3 test, alkali test, Salkowski’s test, Keller-killiani test and CuSO4 test, castor oil, and MgSO4 induced diarrheal test. This extract figured the presence of carbohydrates, flavonoids, tannins, glycosides, triterpenoids, fat and fixed oils. Moreover, both doses of (200 mg/kg and 400 mg/kg) methanolic extract of Ficus hispida leaves significantly (p<0.05, vs. control) reduced the gastrointestinal motility and inhibited the percentage of diarrhoea in antidiarrhoeal models. But 400 mg/kg dose showed better antidiarrhoeal activity than 200 mg/kg dose compared to control in both antidiarrhoeal tests. The results indicate that Ficus...
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