PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF FICUS HISPIDA LEAVESAbstract
As a source of remedies, medicinal plants are widely used as alternative medicines for the treatment or prevention of many diseases. Ficus hispida is traditionally used for treating diarrhoea, wounds, pain, inflammation, diabetes, fever, and neurological disorders. To evaluate the qualitative phytochemical constituents and antidiarrhoeal activity of methanolic extract of Ficus hispida leaves the present study was designed. Phytochemical constituents and anti-diarrhoeal activities were determined and assessed by various tests such as Molisch’s test, Fehling test, Mayer’s test, frothing test, FeCl3 test, alkali test, Salkowski’s test, Keller-killiani test and CuSO4 test, castor oil, and MgSO4 induced diarrheal test. This extract figured the presence of carbohydrates, flavonoids, tannins, glycosides, triterpenoids, fat and fixed oils. Moreover, both doses of (200 mg/kg and 400 mg/kg) methanolic extract of Ficus hispida leaves significantly (p<0.05, vs. control) reduced the gastrointestinal motility and inhibited the percentage of diarrhoea in antidiarrhoeal models. But 400 mg/kg dose showed better antidiarrhoeal activity than 200 mg/kg dose compared to control in both antidiarrhoeal tests. The results indicate that Ficus hispida leaves may provide a potential source of anti-diarrhoeal activities.
S. M. M. Rahman *, S. R. Sajon, A. Ahamed, A. Islam, M. S. Islam and M. I. Hossain
Department of Pharmacy, Faculty of Biological Science and Technology, Jessore University of Science and Technology, Jessore, Bangladesh.
16 May 2018
05 June 2018
13 June 2018
01 August 2018