ANTIANXIETY, ANTICONVULSANT, MYORELAXANT AND HYPNOTIC EFFECT OF POLYHERBAL EXTRACTS ON RODENTSAbstract
The research in alternative medicine and the need for the plant-based medicines that affect the ‘mind’ is developing day to day. The aim of the present study was to explore Leptadenia reticulata (roots), Mimusops elengi (bark) and Evolvulus alsinoides (Whole plant) using different animal models (conditional avoidance response, hole board test, open field test), anticonvulsant (MES induced convulsions), myorelaxant action (rotarod) and hypnotic property (Phenobarbital-induced sleeping) in suitable animal models. Diazepam (2 mg/kg, p.o), Phenytoin (25 mg/kg, p.o) and Phenobarbital sodium (50 mg/kg, i.p) were used as the standard drugs, and the acetone and ethanolic extract were 200 mg/kg, p.o Selected as per OECD guidelines. Results suggested that the extracts produced significant (p<0.001) anti-anxiety, myorelaxant and hypnotic action, but not significant anticonvulsant effect (p<0.05). Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed CNS effects of the acetone and ethanolic extract of the selected plants.
A. T. Selvan and R. Suresh *
Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.
17 May 2018
05 June 2018
13 June 2018
01 August 2018