Posted by admin on Sep 8, 2017 in |
This study evaluated the scientific basis for the traditional use of Aegiceras corniculatum (Myrsinaceae) stem extract as an anthelmintic agent. The study design was an investigation of the traditional anthelmintic medicinal plant Aegiceras corniculatum using in-vitro anthelmintic properties of four extracts of the plant were evaluated using earthworms. The earthworm (Pheretima posthuma) resembles both anatomically and physiologically to the intestinal roundworm parasites of human beings. The four crude stem extracts of Aegiceras corniculatum were petroleum ether extract (50 & 100 mg/ml), chloroform extract (50 & 100 mg/ml), methanol extract (50 & 100 mg/ml) and aqueous extract (50 & 100 mg/ml). The paralysis time of petroleum ether extract (96 ± 6.33 & 76 ± 2.31), chloroform extract (116 ± 4.36 & 92 ± 7.50), ethanol extract (62 ± 3.20 & 34 ± 3.52) and aqueous extract (200 ± 2.22 & 180 ± 3.19) were compared to the standard drug Albendazole suspension 100mg / 5ml (5 ± 1.00). The results showed that the four extracts produced dose-dependent and significant anthelmintic activities....
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Posted by admin on Sep 8, 2017 in |
The present study was conducted to investigate the color strength (K/S), colorfastness, antibacterial and antioxidant properties of silk using fabric Cichorium intybus root extract as a natural dye. Comparative results of color fastness (fastness to wash, rub, light and perspiration) and colorimetric properties (CIELab and K/S values) of dyed silk samples were studied to quantify the effect of mordants and mordanting method. Alum and myrobalan were used as mordants. Three methods of mordanting techniques were used (pre, meta and post-mordanting). The samples showed acceptable color strength and colorfastness values. The antibacterial activity of the dyed samples with and without mordants was tested against common pathogens Escherichia coli and Staphylococcus aureus. The antioxidant property of the dyed fabric was analyzed by DPPH method. Cichorium intybus proved to be very effective in inhibiting microbial growth. The results of DPPH assay were positive for all the samples. The dyeing of silk fabric with Cichorium intybus root extract provided a multifunctional textile material with both antioxidant and antibacterial...
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Posted by admin on Sep 8, 2017 in |
Tunisian flora contains several wild plants with diverse therapeutic uses. As a contribution to the efforts to select natural sources of antitumor compounds, we investigated in this study the antiproliferative activity of several extracts of the Tunisian species: Astragalus gombo, Nicotiana glauca and Artemisia campestris. Dried aerial part (A. gombo and A. campestris) and leaves (N. glauca) were extracted with ethyl acetate, dichloromethane, and methanol. In the vitro anti-proliferative activity of the extracts was tested against the human solid tumor cell lines: HBL-100, T-47D, and WiDr. Tests were performed using the sulforhodamine B (SRB) assay. All extracts of A. campestris and A. gombo were active against all tested cell lines, with GI50 values between 12 and 93 µg/ml. Dichloromethane extract of A. campestris was the most active extract with GI50 of 12 µg/ml against HBL-100 cell line. This kind of cell seems to be the most sensitive regarding all tested extracts. Our results showed that A. gombo, A. campestris and N. glauca are a promising source of natural antitumor...
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Posted by admin on Sep 8, 2017 in |
Teucrium polium L. is a member of the Lamiaceae family and is represented in the Flora of Syria by two variety: Teucrium polium var. angustifolium and Teucrium polium var. mollissimum. Teucrium polium is a wild-growing flowering plant, found abundantly in Syria, and it is used traditional medicine for it’s diuretic, antipyretic, antispasmodic, tonic, anti-inflammatory, antihypertensive, anorexic, analgesic, antibacterial and anti-diabetic effects. Several reports have demonstrated a wide range of beneficial biological and pharmacological activities of the phenylethanoid, phenylpropanoid and flavonoid components, while the furano neo-clerodane diterpenoids present in germander have been implicated in the in–vivo hepatotoxicity of this botanical. Phytochemical studies of this plant have been carried out. Aerial parts of the plant were extracted with petroleum ether at room temperature, and then extract with methanol in Soxhlet, and finally extract with aqueous methanol at room temperature successively. Fractionation of the methanol extract by column chromatography and purification by crystallization yielded three known flavonoids cirsimartin, cirsiliol, and apigenin. The aqueous methanolic extract yielded one new neo-clerodane type diterpenoid, syrapolin...
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Posted by admin on Aug 2, 2017 in |
Combretastatin A-4 (CA-4) is an anti-mitotic agent that is gaining rapid recognition among cancer biologists and clinicians as one of the newer vascular disrupting agents, (VDAs) for cancer therapy. CA-4 belongs to a group of tubulin binding natural products called combretastatin, derived from the African Bush Willow, Combretum caffrum. Due to CA-4’s in-vivo efficacy, several analogs of CA-4 have been synthesized to maximize its solubility and bioavailability. Combretastatin A-4 phosphate is a more soluble form of CA-4 that has completed for treatment of acute myelogenous leukemia and relapsed ovarian cancer. This review attempts to highlight the various CA-4 analogs that have been synthesized and their effectiveness in clinical. Combretastatin A-4 phosphate (CA-4-P) is a biologically very active compound by binding to the colchicine binding site which leads to the inhibition of microtubule polymerization as well as showing antiangiogenic and anticancer effects by selectively shutting down the tumor blood flow. To avoid the disadvantage of rather low in-vivo efficacy resulting from the isomerization of the cis-stilbene derivative to the thermodynamically...
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