Drug delivery via the oral mucous membrane is considered a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual means “under the tongue”, administrating substance via mouth so that the substance is rapidly absorbed via blood vessels under the tongue. The portion of the drug absorbed through t...
NANOTECHNOLOGY IMPROVES THE ACTIVITY OF HERBAL MEDICINES: GREEN SYNTHESIS OF SILVER NANOPARTICLES USING COSTUS AFER LEAF EXTRACT AND ITS EFFECT ON HEMATOLOGICAL INDICES IN ADULT MALE WISTAR RATS
Nanotechnology is a rapidly growing area of scientific interest due to its wide applications in catalysis, solar energy, waste management, and sensing technology. Nanomaterials are efficiently used in the field of medicine for the purpose of drug delivery, diagnosis, treatment of cardiovascular diseases, wound healing, and development of antimicrobial agents. The present study aimed to evaluate th...
SYNTHESIS, CHARACTERIZATION, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME SUBSTITUTED PYRAZOLE DERIVATIVES
A series of substituted acetophenones are condensed with hydrazides to the corresponding hydrazones which are subsequently cyclized by using volumizer-Haack reaction to give new pyrazole derivatives. All the compounds 4a, 4b, 4c, 4d, 4e were screened for antioxidant, anti-inflammatory activity. Few of the compounds showing good antioxidant and anti-inflammatory activity....
Hyperlipidaemia (Adhi dhoola noi) is a well known metabolic disorder, prevalent in 30-40% of the people worldwide. It is one of the most important factors of morbidity and mortality related to atherosclerotic cardiovascular disease and diabetes. Research articles prove hyperlipidaemia as an important factor that determines the risk of atherosclerotic heart disease and endocrinal disorders. Siddha ...
PHYTOCHEMICAL SCREENING ASSESSMENT, ANTIOXIDANT CAPACITY AND ANTIMICROBIAL SUSCEPTIBILITY OF EXTRACTS FROM CECROPIA PACHYSTACHYA TRÉCUL. CECROPIACEAE (URTICACEAE) AS SOURCE FOR HERBAL MEDICINES DEVELOPMENT
Several plants used for medicinal purposes can be found in the Brazilian Cerrado, among which highlights the genus Cecropia used as a bronchodilator, antitussive, anti-diabetic, anti-diarrheal, anti-hypertensive, anti-inflammatory and vasorelaxant. Between species, there is Cecropia pachystachya belongs to the Urticaceae family. This study aims to evaluate the phytochemical screening, antioxidant ...
IDENTIFICATION OF ENDEMIC CURCUMA ALBIFLORA THW. FROM CURCUMA SPECIES GROWN IN SRI LANKA BY DNA BARCODING METHOD
Curcuma is an important genus in traditional medicine. Five plants are reported in Sri Lanka; C. albiflora, C. aromatica, C. longa, C. zedoaria, and C. oligantha. Since the phylogenetic analysis of gene sequences and combining with complete genomic sequences helps to identify the genetic basis of plants, the current study was conducted. Standard CTAB method with little modifications was used for t...
Natural compounds have already contributed to the discovery of new anti-malarial drugs. Atovaquone, artemisinin and its semi-synthetic derivatives as well as clindamycin, erythromycin, azithromycin, chlortetracycline, tetracycline, oxytetracycline and doxycycline, are noteworthy examples of the varied contribution of natural products for the development of effective anti-malarial drugs, particular...
The discovery of drugs for Alzheimer’s disease (AD) therapy that can also permeate the blood-brain barrier (BBB) is very difficult owing to its specificity and restrictive nature. The BBB disruption or drug administration directly into the brain is not an option due to toxic effects and low diffusion of the therapeutic molecule in the brain parenchyma. A promising approach for systemic drug deli...
A BRIEF REVIEW ON SOLANUM XANTHOCARPUM ALONG WITH THE EVALUATION OF ANTICANCER POTENTIAL IN CARPESTEROL
The “deadly nightshade” family, commonly known as "black nightshades," it’s also used as a traditional medicine system in a country like India and China. Solanum xanthocarpum is known to contain alkaloids, steroids, glycol-alkaloids, steroid saponins, glycoproteins, that exhibit antitumor activity. This review explores the phytopharma-cological properties of Solanum xanthocarpum and summariz...
COMPARISON, FORMULATION DEVELOPMENT AND BASIC EVALUATION OF IN-VITRO ANTI-UROLITHIATIC POTENTIAL OF OCIMUM TENUIFLORUM AND MENTHA PIPERITA MEDICINAL PLANT SPECIES
Urolithiasis or kidney stones is defined as a urinary stone originating anywhere in the urinary tract. Urolithiasis plays a significant economic burden in the healthcare system, especially in developing countries, owing to changes in food habits and lifestyle due to a significant increase in the disease over the last few decades. Medicinal plants are established as renewable sources with antiuroli...