STUDY OF THE LATEST DISCOVERIES OF POTENTIAL ANTIOXIDANT COMPOUNDS TO MODULATE OXIDATIVE STRESS-MEDIATED BY FREE RADICALS LEADING TO NEUROTOXICITY IN PDAbstract
Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson’s disease (PD)) is characterized by necrosis of dopaminergic neurons within the substan tianigra pars compacta are ain the midbrain. The PD cause is still unknown and seems to be multifactorial. Oxidative stress and mitochondrial impairment have been the main consequences, which offer prominent clues regarding the disease mechanisms. The effect of free radicals and oxidative stress on the cascade of events resulting in dopamine cell degeneration in PD has been demonstrated. In-built protective mechanisms, including enzymatic and non-enzymatic antioxidants within the CNS, effectively prevent neuronal cell loss because of free radicals. However, aging is associated with a decrease in the production of these antioxidants. Thus, antioxidant therapy alone or combined with available treatment methods offers an attractive method to treat or prevent neurodegeneration in PD. We summarized the recent discoveries of potential antioxidant agents to modulate free radical-mediated oxidative stress resulting in neurotoxicity in PD.
Seyyed Hossein Hassanpour * and Seyyedeh Zeinab Karami
Young Researchers and Elite Club, Yassoj Branch, Islamic Azad University, Yasooj, Iran.
13 September 2021
11 November 2021
20 November 2021
30 November 2021