Posted by admin on Dec 31, 2020 in |
Objective: The aim of this study was to evaluate the anticancer activity of a series of six structurally related [1, 4]-Benzoquinone monooximes and to investigate structure-activity relationships (SAR) of these compounds. Materials and Method: The mono-oximes obtained by oximination of para-benzoquinones 1-4 had their structures confirmed by ¹H NMR, 13C NMR. The cytotoxic study was assessed by the MTT assay on three tumor cell lines: HL60 (promyelocytic leukemia), NCI-H292 (lung cancer), and MCF-7 (breast adenocarcinoma). Results: Six oximes were synthetized 2 – methyl-[1,4]-benzoquinone oxime tosylate (I), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime tosylate (II), 5-isopropyl-5-mehyl-[1,4]-benzoquinone oxime tosylate (III), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime (IV), 2,5-dimethyl-[1,4]-benzoquinone oxime tosylate (V), 2-methyl-[1,4]-benzoquinone oxime tosylate (VI). Compounds II to V showed significant activity against all cell lines; while compound I and VI presented low or no activity. Conclusion: These experimental data lead to the conclusion that oximes (II –V) may be used as potential starting structures for the design of novel anticancer...
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Posted by admin on Oct 31, 2020 in |
The main objective of this present work is to evaluate the anthelmintic activity of crude alcohol extracts of the flowers of kachnar (Bauhinia variegata) against Pheretima posthuma as a test worm. The activity was assessed by worm motility assay, which involved the determination of time of paralysis and death of worms. The preliminary phytochemical study of the alcoholic extract was also carried out. The alcoholic extracts exhibited a dose-dependent (25, 50, and 100 mg/ml) inhibition of spontaneous motility and time of death of the worms. The alcoholic extract was found to be effective; the activity was comparable with the standard drug Piperazine citrate and water as a control....
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Posted by admin on Oct 31, 2020 in |
Medicinal plant is the basic and most significant part of the traditional medicinal system. The different plant contains medicinal properties, also known as an herbal plant. Bombax ceiba L. plant of the Bombacaceae family shows much Pharmacological activity. It is also called as Kate Savar and Semal. It is a native plant in western Africa. It is naturally obtained in Pakistan, India, and Myanmar. Bombax ceiba L. is a big and tall tree with a height of approximately 30m and having a diameter of 58 to78 cm. It grows in a straight direction with having a cylindrical stem and wide base. Bombax ceiba L. contains principal constituents that are tannin and glycosides which are present in part of the leaf and stem. The part of the stem shows the presence of some lupeol and b-sitosterol, and the leaf shows the presence of alkaloid. The root bark contains the 3 naphthalene derivatives. Bombax ceiba L. shows many pharmacological properties. The stem bark of the plant is used for a wound....
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Posted by admin on Oct 31, 2020 in |
Public interest on herbal drugs increase every passing day in both developed and developing countries. However, its regulations more strict in developed countries than in developing countries. Clarifying the effectiveness and adverse effects of this product is becoming more important. Calendula officinalis and Taraxacum officinale both commonly using in herbal-based therapies due to the speculated antibacterial and anti-cancer effects of them. Several effects of these plants have been associated with their ingredients, such as phytochemicals, flavonoids, essential oils, etc. In this study, we aimed to investigate antibacterial effects and potential anticancer effects of commercial Calendula officinalis and Taraxacum officinale products obtained from herbalist. Antibacterial effects of methanolic extracts of Calendula officinalis and Taraxacum officinale were evaluated via microbroth dilution technique using the Clinical Laboratory Standards Institute (CLSI) recommendations. Anti-cancer effects were evaluated with the MTT cytotoxicity test on the human neuroblastoma cell line (SH-SY5Y). Our results indicate that commercial products show lower antibacterial effects separately and with 1:1 combination that was reported in previous different studies. It has been...
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Posted by admin on Oct 31, 2020 in |
For humankind, a major wellspring of the bioactive compound, the family Passiflora L. contains near about 520 types of dicotyledonous plants in the family Passifloraceae. Passiflora incarnata and P. alata, likewise generally known as passionflower. Two types of perpetual climbing vine with lovely extraordinary flower and scrumptious organic products that become around the world, favoring subtropical, ice-free atmospheres. The arrangement, by and large, found in the tropical, semi-tropical United States (Virginia to Florida and as far west as Texas), Mexico, Central American, and from Brazil to Paraguay through northern Argentina. Treatment of some diseases like anxiety, insomnia, convulsion, sexual dysfunction, cough, and cancer. Passionflower is at present authority in the national Pharmacopeia’s of Egypt, France, Germany, and Switzerland and furthermore monographed in the British Herbal Pharmacopeia. The present article including the detailed about of pharmacological properties of Passion flower and to provide information for further research on passion...
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