ANTIBACTERIAL AND ANTICARCINOGENIC EVALUATION OF COMMERCIAL CALENDULA OFFICINALIS AND TARAXACUM OFFICINALEAbstract
Public interest on herbal drugs increase every passing day in both developed and developing countries. However, its regulations more strict in developed countries than in developing countries. Clarifying the effectiveness and adverse effects of this product is becoming more important. Calendula officinalis and Taraxacum officinale both commonly using in herbal-based therapies due to the speculated antibacterial and anti-cancer effects of them. Several effects of these plants have been associated with their ingredients, such as phytochemicals, flavonoids, essential oils, etc. In this study, we aimed to investigate antibacterial effects and potential anticancer effects of commercial Calendula officinalis and Taraxacum officinale products obtained from herbalist. Antibacterial effects of methanolic extracts of Calendula officinalis and Taraxacum officinale were evaluated via microbroth dilution technique using the Clinical Laboratory Standards Institute (CLSI) recommendations. Anti-cancer effects were evaluated with the MTT cytotoxicity test on the human neuroblastoma cell line (SH-SY5Y). Our results indicate that commercial products show lower antibacterial effects separately and with 1:1 combination that was reported in previous different studies. It has been observed that both methanolic plant extracts were shown 100% viability in desired concentrations.
A. K. Arif, H. Özger, K. Cansever, M. Kara *, F. N. Yılmaz, B. Ö. Çelik
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit-Istanbul, Turkey.
29 May 2020
23 September 2020
28 September 2020
01 November 2020