Posted by admin on Jul 29, 2016 in |
To evaluate the possible antifertility effect of 50% ethanolic extract of C. bonducella seeds in male rats. Adult, healthy, male Wistar rats were randomly selected and divided into three groups each having 7 rats. Group, I rats were treated with vehicle only and served as control. While group II and Group III rats were orally treated with C. bonducella extract at 200 mg and 400 mg/kg body weight/day, respectively for 60 days. The result of the present study indicated that there was a significant decrease in the relative weights of testes and accessory sex glands in treated rats. The density, motility, and viability of spermatozoa obtained from cauda epididymis were significantly (P<0.01 at 200 mg and P<0.001 at 400 mg) diminished in both treated groups as compared to control group. The serum testosterone level also showed significant (P<0.05 at 200 mg and P<0.01 at 400 mg) decline. The fertility rate and litter size decreased significantly in extract treated rats. Extract treatment also induced alteration in the biochemical milieu of...
Read More
Posted by admin on Jul 29, 2016 in |
Prophet Mohammed calls Nigella sativa seed as a medicine of blessings. Nigella sativa is an herbaceous plant and cultivated in the Middle East, South East Asia and some part of Europe. Nigella sativa seed has been in use in the Middle East, South East Asia and some part of Europe over 2000 years. Until date lot of research, studies are conducted to prove the therapeutic utility of Nigella sativa seeds. In these various studies, Nigella sativa seeds and its derivative showed therapeutic activity against allergy, cough, and diabetes, different types of cancer and skin infections. It is one of the widely used spices in the Middle East, South East Asia and some part of the Europe Nigella sativa seed is intensively studied for its chemical composition. It is reported to contain Thymoquinone, Nigellimine-N-oxide, Nigellicine, Nigellidine, Nigellone, Dithymoquinone, Thymohydroquinone, Thymol, Arvacrol, 6-methoxy-coumarin, 7-hydroxycoumarin, Oxy-coumarin, Alpha-hedrin, Steryl-glucoside, Tannins, Flavinoids, Essential fatty acids, Essential amino acids, Ascorbic Acid, Iron and Calcium. The presence of these natural actives makes Nigella sativa seed as...
Read More
Posted by admin on Jul 29, 2016 in |
Several reports are available for Rhododendron arboreum which is limited to its subspecies nilagiricum. The present study intended to examine the bioactive compounds and the antimicrobial activity of leaf extracts of R. arboreum Sm spp. nilagiricum (Zenker) Tagg against medically important four bacterial (Streptococcus pyogene, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia) and two fungal (Candida albicans and Trichoderma viride) strains. Agar well diffusion method is applied to assess the antimicrobial activity of the aqueous and methanol extracts of the plant sample. Various fractions of aqueous, ethanol, methanol and chloroform extracts confirmed the presence of alkaloids, phenols, flavonoids, tannins, saponins, terpenoids, steroids, carbohydrates, glycosides, amino acids, and proteins. The methanol extract of leaf revealed a promising antibacterial and antifungal activity against S. aureus and T. viride respectively. This study shows a broad and great therapeutic potential of the leaf extract. However further studies are necessary for this potent leaf extracts to evaluate the other parameters of antimicrobial...
Read More
Posted by admin on Jul 29, 2016 in |
The present investigation deals with the in-vivo and in-vitro mast cell stabilizing the activity of fruits of Terminalia chebula ethyl acetate and methanol extracts at 500 mg/kg body weight. In egg albumin induced degranulation studies, Kitotifen as a standard was found to inhibit degranulation to an extent of 80.12%, where as ethyl acetate and methanolic extracts inhibited degranulation to 58.98% and 44.56% respectively similarly in compound 48/80 induced mast cell degranulation in rats ethyl acetate and methanol extracts of Terminalia chebula and standard Kitotifen showed the following percentage inhibition of degranulation of mast cell 40.28%, 51.19% and 75.12 respectively. In in-vivo study ethyl acetate and methanolic extracts at the dose of 500 mg/kg bodyweight inhibited degranulation of mast cell to the extent of 46.5 % and 37.33%...
Read More
Posted by admin on Jul 29, 2016 in |
Essential hypertension (HTN) is the most prevalent type of HTN, affecting 90 to 95% of hypertensive patients. HTN accounts for a large proportion of all deaths and disability worldwide. It has been predicted that by the year 2020, there will be an increase of almost 75% in the global cardiovascular disease burden because of hypertension. Persistent HTN is one of the risk factors for strokes, heart attacks, heart failure, and arterial aneurysm and also a leading cause of progressive and chronic kidney failure. Unani scholars were familiar with the clinical manifestations of hypertension if we analyze this disease in the context of ‘Imtila’ which is manifested by symptoms like headache, vertigo, epistaxis, etc. In this article, the authors have tried to put forth the core concepts of Unani medicine on hypertension in the context of etiopathogenesis, prevention, and pharmacological...
Read More