IN-VIVO AND IN-VIRO MAST CELL STABLIZING ACTIVITY OF ETHYL ACETATE AND METHANOL EXTARCT OF TERMINALIA CHEBULA FRUITS: A THERAPEUTIC APPROACH FOR ASTHMA
AbstractThe present investigation deals with the in-vivo and in-vitro mast cell stabilizing the activity of fruits of Terminalia chebula ethyl acetate and methanol extracts at 500 mg/kg body weight. In egg albumin induced degranulation studies, Kitotifen as a standard was found to inhibit degranulation to an extent of 80.12%, where as ethyl acetate and methanolic extracts inhibited degranulation to 58.98% and 44.56% respectively similarly in compound 48/80 induced mast cell degranulation in rats ethyl acetate and methanol extracts of Terminalia chebula and standard Kitotifen showed the following percentage inhibition of degranulation of mast cell 40.28%, 51.19% and 75.12 respectively. In in-vivo study ethyl acetate and methanolic extracts at the dose of 500 mg/kg bodyweight inhibited degranulation of mast cell to the extent of 46.5 % and 37.33% respectively.
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