Posted by admin on Sep 30, 2025 in |
Bryophytes are known for chemically diverse group of non-vascular plants, and secondary metabolite of these plants, particularly in their lipophilic fractions yet remain unexplored in most of the plants. The present study deals with the analysis and investigation of the non-polar chemical composition of hexane extract of Bryum capillare using Thin Layer Chromatography (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) technologies. TLC revealed the different bands of presence of non-polar compounds and GC-MS analysis identified a range of hydrocarbons, fatty acids esters, terpenoids including diterpenes, triterpenes. These findings contribute to the scant phytochemical literature available on mosses and suggest the existence of non-polar bioactive compounds that may have therapeutic...
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Posted by admin on Sep 30, 2025 in |
Diabetic wounds represent one of the most challenging complications of diabetes mellitus, characterized by impaired tissue regeneration, prolonged inflammation, and high susceptibility to infection. Conventional therapies often fail to achieve satisfactory healing outcomes, necessitating the exploration of novel strategies. Probiotics, with their antimicrobial, immunomodulatory, and regenerative properties, have emerged as promising candidates for wound care. This study investigated the therapeutic potential of three commercially available probiotic strains Bacillus clausii (Enterogermina®), Lactobacillus sporogenes (Sporlac®), and Bifidobacterium longum (Florachamp®) incorporated into a PEG–glycerol-based gel formulation for topical application. The developed gels were characterized for physicochemical stability, spreadability, pH, and viscosity, alongside confirmation of probiotic viability. In vitro assays revealed variable antagonistic activity against Staphylococcus aureus and Pseudomonas aeruginosa. Using a streptozotocin–nicotinamide-induced diabetic excision wound model in Wistar rats, the probiotic gels demonstrated significantly enhanced wound contraction, accelerated closure, and histological evidence of collagen deposition and re-epithelialization compared to diabetic controls. By Day 21, probiotic-treated groups exhibited healing efficacy comparable to the standard treatment (Placentrex® gel), with formulations containing Lactobacillus sporogenes and...
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Posted by admin on Aug 31, 2024 in |
Barleria cristata, a member of the Acanthaceae family, is a widely distributed perennial shrub indigenous to India. Renowned for its significance in Ayurvedic medicine, this plant is used for its diverse biological and pharmacological properties. The genus Barleria is commonly utilized to treat various ailments such as boils, bee and snake bites, asthma, leprosy, cough, jaundice, and toothaches. Phytochemical screenings of different extracts have identified the presence of alkaloids, carbohydrates, glycosides, phytosterols, flavonoids, phenolic compounds, terpenoids, anthraquinones, and saponins. This review aims to provide a comprehensive scientific overview of Barleria cristata, focusing on its geographical and botanical characteristics and pharmacological activities. The ethnomedicinal applications of this plant include treatments for respiratory diseases like asthma, cough, bronchitis, and tuberculosis. Additionally, Barleria cristata has been noted for its ornamental value due to its vibrant flowers. It also plays a role in soil stabilization and erosion control. Pharmacological studies have demonstrated Barleria cristata’s anti-inflammatory, antibacterial, antidiabetic, antimicrobial, antioxidant, wound-healing, and...
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Posted by admin on Aug 31, 2024 in |
Black cumin (Nigella sativa L., family: Ranunculaceae) is an annual herb known for its extensive medicinal properties, in addition to its commercial significance as a spice-producing plant. The seeds of black cumin are widely used in traditional herbal medicine across the globe for the treatment and prevention of various diseases. They contain a variety of medicinally important chemical compounds, including thymoquinone, thymohydroquinone, thymol, carvacrol, nigellidine and α-hederin. Black cumin exhibits numerous therapeutic effects, such as diuretic, antiurolithic, anti-inflammatory, antioxidant, anticancer, anthelmintic, antidiabetic, gastrointestinal disease relief, asthma management, antihistamine, antihypertensive, hypoglycemic, antifungal, hair health, fertility enhancement, antibacterial, and bronchitis...
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Posted by admin on Aug 31, 2024 in |
Plants serve human as a primary source of food, shelter, and medicine. So, understanding the plants uses in treating diseases is very important for leading a healthier life. Helminthes infection are usually found in community and are well recognized as cause of much acute and chronic illness among the individual as well as cattle’s. For evaluating that we select the Pherithema posthuma a Helminthes is frequently known as earth-worms. For that we evaluated the anthelmintic activity of aqueous and methanolic extracts of leaves of Euphorbia hirta linn. (euphorbiaceae) using different concentration of above solvent extract we evaluated the Time of paralysis (P) and Time of death (D) of the worms. The main active constituent responsible for showing the anthelmintic efficacy in the Euphorbia hirta plant is believed that Quercetin, a flavonoid. This plant contains several bioactive compounds, butquercetin has been widely studied for its broad-spectrum biological activities including anthelmintic activity. Albendazole (Std) was used as standard. Anthelmintic drug and Dis. H2O was used as a control. The result of...
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