Posted by admin on Jan 31, 2025 in |
Beta vulgaris is commonly called beetroot. This is the taproot portion of the beet plant. There are types of beets grown in Egypt, India, Europe and Ukraine. It is used in the traditional Indian system of medicines. Beta vulgaris Linnaeus is among the top ten most powerful vegetables as an excellent source of phytochemicals. It is also known for its high content of biologically active substance such as betalains, polyphenolic compounds, vitamin, carotenoids and other nutrients including sodium, potassium, and magnesium. Some parts of this plant are used in the medicinal system as antioxidant, antidepressant, antimicrobial, antifungal and anti-inflammatory, diuretic, expectorant and carminative. Beet (Beta vulgaris L.) as a health-promoting functional food may be potentially beneficial in cancer. As a source of polyphenol, flavonoids, dietary nitrates and other beneficial nutrients, beetroot supplementation may provide a holistic way to prevent cancer and manage the side effects of...
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Posted by admin on Jan 31, 2025 in |
Morinda citrifolia, known as Indian mulberry, Nuna, or ach in India and “Morinda citrifolia (Noni)” in Hawaii and Polynesia, a medicinal plant with a long story of traditional use. It possesses numerous biological activities, including antibacterial, antiviral, antifungal, anticancer, anthelminthic, analgesic, hypotensive, anti-inflammatory, and immune-boosting effects due to its diverse phytochemicals. Its increasing popularity has led to its incorporation into various products across industries, serving as a natural source for chemical reagents, eco-friendly pesticides, and medications. Different parts of Morinda citrifolia, such as the fruit, seeds, bark, leaves, and flowers, are utilized for their unique nutritional and therapeutic benefits, particularly the fruit, valued for its rich chemical composition. This review explores the botany, ethno-pharmacological applications, phytochemistry, pharmacological activities, safety and quality, economic potential, and marketed products of Morinda citrifolia’s fruit, seeds, leaves, and roots. Additionally, it examines the phytochemical compounds identified through in-vitro and in-vivo...
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Posted by admin on Jan 31, 2025 in |
Context: Epilepsy is a neurological disorder of brain in which the clusters of neurons, occasionally signal abnormally and cause strange emotions, sensations, and behavior, or sometimes muscle spasms, convulsions, and loss of consciousness. Lagenaria siceraria (Molina) Standley (LS), commonly known as “bottle gourd” (English), possesses several medicinal properties; little is known about its action as a nerve tonic. Objective: The purpose of this study was to characterize (or to study) the anti-epileptic potential of the bioactive fractions of methanolic extract of LS fruits through pharmacological screening. Materials and Methods: The experiment was conducted in specific animal models i.e., Pentylenetetrazole (PTZ)-induced convulsions and Maximal electroshock-induced seizures (MES) in Swiss albino mice to evaluate anti-epileptic effects. The effect of the fractions was also tested on motor coordination using the rota-rod apparatus. Results and Conclusions: Preliminary phytochemical screening of the methanolic extract of LS and its fractions showed a huge range of phytoactive compounds. Among all the fractions, chloroform and acetone fractions were found to have more number of such phytoactive compounds....
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Posted by admin on Jan 31, 2025 in |
Essential oils are concentrated hydrophobic liquids containing volatile chemical components obtained from plants. They are well-known for their medicinal effects and numerous uses. This paper examines the pharmacognostic profiles of clove (Syzygium aromaticum), tulsi (Ocimum sanctum), and vetiver (Vetiveria zizanioides), highlighting their phytochemical composition, medicinal qualities, and pharmacological activity. Clove oil, high in eugenol, has been extensively studied for its antibacterial, anti-inflammatory, and analgesic qualities, making it an important element in dental and topical formulations. Tulsi, regarded as a sacred plant in Ayurveda, produces an essential oil rich in eugenol, methyl eugenol, and beta-caryophyllene, which has adaptogenic, immunomodulatory, and anti-stress properties. Vetiver, also known as “khus,” generates an essential oil rich in sesquiterpenes such as khusimol and vetiverol, known for their relaxing, anti-inflammatory, and antioxidant properties. The pharmacognostic examination of these essential oils covers macroscopic and microscopic properties, phytochemical screening, and quality control measures. Their broad-spectrum antibacterial action and few side effects have positioned them as promising options in current therapies. Furthermore, the synergistic potential of these oils in...
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Posted by admin on Jan 31, 2025 in |
Paclitaxel, a potent anticancer agent, was first isolated from the bark of Taxus brevifolia in the 1960s and has since become a cornerstone in chemotherapy. Its anticancer efficacy stems from its ability to stabilize microtubules, preventing their disassembly, which inhibits mitosis and ultimately induces apoptosis in cancer cells. This mechanism of action makes paclitaxel particularly effective against a variety of cancers, including ovarian, breast, and non-small cell lung cancer. Despite its clinical success, the isolation of paclitaxel from the Taxus species is limited by low yields and environmental sustainability concerns, prompting the development of alternative synthetic routes. The synthesis of paclitaxel has posed significant challenges due to its complex structure, particularly the C-ring, which is pivotal for its biological activity. Over the years, total syntheses have been achieved using both chemical and semi-synthetic approaches, with the latter being more commercially viable. One notable method involves converting baccatin III, a compound found in Taxus, into paclitaxel via chemical modifications. Stability issues are another hurdle for paclitaxel’s therapeutic use, as its...
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