Posted by admin on Jan 31, 2024 in |
Despite the introduction of new antiepileptic medicines (AEDs) over the past two decades, more than 30% of epilepsy patients still have refractory disease. Combined administration of AEDs or the use of novel AEDs is the most popular therapeutic choice when surgical therapy cannot be provided, even though a tiny number of these resistant individuals may become seizure free when a new AED is added. Lacosamide (LCM), which has novel modes of action and advantageous safety profiles, is the most recent AED to receive approval in Europe and the USA. This article discusses the efficacy and safety of LCM as determined by phase II and III clinical trials, as well as its molecular mechanisms of action and pharmacokinetic characteristics. It is also explored how LCM compares to other AEDs that are currently on the...
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Posted by admin on Jan 31, 2024 in |
Medicine presently used to deal with cough are the various maximum notably used over the counter drug treatments in the international, in spite of a recent evaluation suggesting that there is a bit evidence to comparable drug treatments produce any significant efficiency. Syrup is commonly useful and famous dosage form which is used for the remedy of cough and bloodless. We organized the herbal cough syrup by means of including Jaggery base and decoction of natural capsules together with Pudina, Tulsi, Cinnamon, Jaggery and other natural excipients. The natural cough syrup is formulated by using decoction method. Including the decoction of natural capsules with base of Jaggery is beneficial to the formulation for thick and preserves the system. That turned into beneficial to increase the shelf lifestyles of components of natural syrup. The brought Jaggery sweetener also can help to growth the palatability of some natural drugs. The ultimately increase the herbal cough syrup with the bottom of Jaggery. The purpose of this examine is to develop a herbal...
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Posted by admin on Jan 31, 2024 in |
Objective: Major Depressive Disorder (MDD) is a psychological disease with a growing global burden. Oxidative stress has been shown to be a causative mechanism of MDD. This research aimed to evaluate the effect of antioxidant-rich fruits (mango, carrots and watermelon) on oxidative stress markers in rats treated with Dexamethasone to induce depression. Method: Thirty (30) rats were grouped into 5: Group 1 (positive control), Group 2 (treated with 2.6 mg/kg body weight Dexamethasone only), Group 3 (treated with 2.6 mg/kg b.w. Dexamethasone and 10.53ml/kg b.w. of watermelon juice), Group 4 (treated with 2.6 mg/kg body weight Dexamethasone, and 10.53ml/kg b.w. of carrot and mango juice) and Group 5 (treated with Gingko Biloba). The lipid profile and C-reactive protein (CRP) were determined using blood samples. Brain homogenate was used to determine oxidative stress parameters SOD, GPx, GSH, MDA, and serotonin levels. Results: Results of the research showed a significant increase in HDL and a significant decrease in LDL, TAG and MDA levels in Group 4. A significant increase was observed...
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Posted by admin on Feb 28, 2023 in |
The present study aimed to investigate the essential oil of Solenostemon monostachyus aerial part extract and its antioxidant and phytochemical potency. The essential oil of S. monostachyus aerial part was obtained by hydrodistillation using Clevenger-type apparatus, and the aqueous extract by infusion. Gas chromatography-mass spectrometry analysis of the essential oil gave twenty-two compounds as the major constituents with their retention factor. A total of forty-three compounds were identified of which limonene (55.40 %) and neral (10.39%) were found as major compounds followed by trans-verbenol (6.43%) and decanal (3.25%). The aqueous extract’s phytochemical analysis revealed terpenes, alkaloids, sterols, tannins, reducing sugar, flavonoids, saponins, and anthraquinones. HPLC analysis gave sixteen peaks, including tannins, caffeic acid, rutin, ferulic acid, morin, and apigenin. S. monostachyus exhibited antioxidant activity from the first dilution at 20 mg/mL up to the ninth dilution at 0.08 mg/mL in 2-fold dilutions signifying the presence of antioxidant compounds at those concentrations. Therefore, the results showed that the aqueous and hydroalcoholic extract of Solenostemon monostachyus exhibited antioxidant...
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Posted by admin on Feb 28, 2023 in |
Drug delivery via the oral mucous membrane is considered a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual means “under the tongue”, administrating substance via mouth so that the substance is rapidly absorbed via blood vessels under the tongue. The portion of the drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in geriatric, pediatric and psychiatric patients with dysphagia. Sublingual drug delivery shows fast therapeutic action than orally ingested drugs with fewer side effects. This review highlights advantages, disadvantages, different sublingual Gland, sublingual formulations such as tablets, films drops, sprays etc, and evaluation...
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