Posted by admin on Feb 28, 2026 in |
People worldwide have long sought effective ways to alleviate pain, a major symptom of many clinical conditions. To achieve better pain control, there is a continuous need to discover new and effective therapeutic agents. Lime peels (Citrus aurantifolia) have been traditionally used to manage various ailments, including pain and infections, and have also been reported to protect several vital organs. Preliminary phytochemical screening and oral acute toxicity studies were conducted on Citrus aurantifolia peels extract (CAPE). No mortality was recorded during the acute toxicity study; therefore, the LD₅₀ of CAPE was estimated to be greater than 2000 mg/kg. In the acetic acid–induced writhing test, CAPE produced significant (p < 0.001) and non–dose-dependent inhibition of pain, with percentage reductions of 56.9%, 66.5%, and 64.9% at doses of 100, 200, and 400 mg/kg, respectively. In the formalin-induced pain model, CAPE at 200 and 400 mg/kg significantly (p < 0.001) reduced paw-licking time in both the first and second phases. In addition, CAPE significantly increased latency time (area under the curve) and...
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Posted by admin on Feb 28, 2026 in |
Cassia fistula is commonly referred to as the golden shower tree is a member of the family Fabaceae. It derives its name due to its catchy yellow flower and lengthy long seed. Aragvada or the plant species called the “disease killer” has been used in the past to treat respiratory tract infections and congestion in the upper tract. In Ayurvedic medicine it has been applied in the treatment of Vata, Pitha and Kappa. The numerous components of the plant such as pods, pulp, leaves, bark, and flowers are applied in treating various diseases such as skin diseases, diabetes, constipation, infections, and inflammation. This page aims at compiling a summary of the literature available on the botany, ethnomedicinal potential, phytochemistry, pharmacological effects, safety, and formulation development of Cassia fistula. The compounds possess strong antioxidant, anti-inflammatory, antimicrobial, anti-diabetic, hepatoprotective, anti-tumor, antitussive and laxative properties. This thorough review of the literature offers a base to the further pharmacological research as it summarizes the current information on the therapeutic usefulness of Cassia...
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Posted by admin on Feb 28, 2026 in |
The present study aimed to formulate and evaluate a polyherbal capsule using aqueous extracts of Vinca rosea, Curcuma longa, and Dalbergia sissoo. Plant materials were collected, authenticated, dried, and extracted using a traditional aqueous extraction method. Pre-formulation studies were conducted to assess powder flow properties, including bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose. Six formulations (PC1–PC6) were prepared by wet granulation and filled into size “0” hard gelatin capsules using a manual plate method. The capsules were evaluated for organoleptic characteristics, weight variation, disintegration time, moisture content, drug content, in-vitro dissolution, and stability under varying temperature and humidity conditions. Among all formulations, PC1 exhibited superior flow properties, uniform weight, rapid disintegration, and maximum drug release (94.77% at 30 minutes). Stability studies revealed good stability under ambient and moderately elevated temperatures, while degradation occurred at higher temperature and humidity. Overall, the results demonstrate that the developed polyherbal capsule is pharmaceutically acceptable, stable under recommended storage conditions, and holds promise for effective oral herbal...
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Posted by admin on Feb 28, 2026 in |
Infertility is a growing global health concern affecting both men and women. In tribal regions of India, traditional medicinal plants remain the primary source of treatment for reproductive disorders. The Akola region of Ahilyanagar District (Maharashtra) possesses a profound, traditional knowledge base on botanicals that boost reproductive health. Objective: The present study aims to document fertility-promoting medicinal plants used by tribal communities of the Akola region and to correlate traditional claims with available pharmacognostic, phytochemical, and pharmacological evidence. Materials and Methods: Ethnobotanical surveys were conducted through personal interviews with tribal healers and elderly practitioners. Plants were identified botanically and validated using standard floras. Literature analysis was performed using Scopus, PubMed, and peer-reviewed pharmacognosy journals to evaluate pharmacological mechanisms. Results: A total of 40 medicinal plant species belonging to 29 families were documented. These plants are traditionally used as fertility enhancers, aphrodisiacs, or reproductive tonics. Pharmacological evidence indicates mechanisms such as antioxidant activity, hormone modulation, adaptogenic action, and gonadoprotective effects. Conclusion: Traditional fertility-promoting plants of the Akola region possess significant...
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Posted by admin on Feb 28, 2026 in |
Vitex madiensis, consumed daily as a tea named Tikoni, is widely used in traditional medicine in Congo Brazzaville to treat fever, pain, inflammation, malaria, dysentery, female infertility, mental illness and epilepsy. Its aqueous leaf extract does not exhibit acute toxicity. Its pharmacological effects against pain, inflammation, insomnia, oxidative stress, and Plasmodium falciparum are very promising. The objective of this study was to investigate the subchronic toxicity of its aqueous extract at a dose of 200 mg/kg orally in Wistar rats over 42 days. Toxicity assessments were conducted on days 14, 28, and 42. The results show that the Tikoni tea aqueous extract does not significantly reduce body weight gain and the growth of certain vital organs. However, liver and lung weights in males, and liver and spleen weights in females, decreased significantly. This extract decreased platelet counts in both sexes and significantly increased leukocyte counts in males. ALT and ALP activities increased significantly in males, while in females, AST, ALT, and ALP activities decreased significantly, and blood glucose levels...
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