Posted by admin on Feb 28, 2015 in |
A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Medicinal plants have been considered as an important therapeutic aid for alleviating ailment of humankind. Numerous plants and polyherbal formulations are used for the treatment of liver diseases. This present investigation was aimed at assessing the hepatoprotective activity of aqueous, ethanol and acetone extract of Sesbania grandiflora leaves against carbon tetrachloride (CCl4) induced liver damage in Albino rats. Silymarin as a standard drug for comparing the activity. The activity was assessed by comparing the biochemical parameters in serum levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase of plant extracts treated group with carbon tetrachloride treated animals. Results showed, ethanolic extract treated group showed highly significant activity (P<0.001), whereas aqueous extract treated group has shown the significant (P<0.01) action but less compared with ethanolic extract, acetone treated group showed moderate action. Plant extracts restore biochemical enzymes and bring down to normal as compared to standard drug silymarin....
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Posted by admin on Feb 28, 2015 in |
Emergence of multidrug-resistant strains of pathogens and adverse effects of antibiotics have rapid lead search for new antimicrobials. Medicinal plants have gained more importance as a source of alternative and effective drugs. Euclea racemosa sub sp. schimperi (DC.) Dandy (Ebenaceae) has many traditional uses against infections and related disorders. The objective of this study was to evaluate the antibacterial potential and identify major phytochemical groups in root extracts of E. racemosa. Root part of the plant was extracted by maceration using methanol, acetone, and chloroform. Extracts were subjected to antibacterial screening against seven bacteria strains: Staphylococcus aureus (ATCC215223), Streptococcus pneumonia (ATCC49619), Streptococcus pyogenes (ATCC19615), Escherichia coli (ATCC259292), Klebsiella pneumonia (ATCC70060), Pseudomonas aeruginosa (ATCC27853), and Salmonella typhi (ATCC1912/R). Well, the diffusion method was used to perform the antibacterial screening. Determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and phytochemical screening was also done on the extracts. Results indicated that the different extracts displayed significant (P<0.05) antibacterial activities and the methanol extract were more active. Flavonoids, glycosides, phenols, saponins,...
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Posted by admin on Feb 28, 2015 in |
Plants are valuable sources of natural products. Despite the availability of different approaches for the discovery of therapeutically, natural products remain as one of the best reservoirs of new structural types. They play a major role in the cure of various diseases from ancient time. Role of plant metabolites to inhibit the growth and activity of pathogenic bacteria is cherished. Research towards the invention of sources of plant metabolites gives sustenance against the problem of development of resistant pathogen. The review presents information about some new sources of phytometabolites against...
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Posted by admin on Feb 1, 2014 in |
Background: Ascophyllum nodosum has been used in oriental medicine to treat a variety of remedies, including some neurological disorders. Ascophyllum nodosum rich in phenolic antioxidant (rich in polyphenol) have been identified as major active component exhibiting antioxidant, anti-inflammatory and neuroprotective effects. The present study is to evaluate the neuroprotective effect of Ascophyllum nodosum on experimentally induced Global Cerebral Ischemia/Reperfusion Injury in mice. Material and Methods: Neuroprotective activity was carried out by global cerebral ischemia on Swiss albino mice by carotid artery occlusion for 17 min followed by 24 h reperfusion. Then after 24 h blood sample was collected by retro-orbital route and after that mouse was sacrificed by cervical dislocation under light area, the brain was removed for various biochemical analyses. Results: Ascophyllum nodosum hydroalcholic extract showed dose-dependent neuroprotective activity by a significant decrease in lipid peroxidation (LPO), lactate dehydrogenase (LDH) and serum nitrite level in extract treated the group as compared to the ischemia/reperfusion group. Cerebral infraction area was significantly reduced in extract treated groups as compared to...
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Posted by admin on Feb 1, 2014 in |
Objective: The present study was aimed to evaluate the antioxidant and hepatoprotective activity of methanolic extract of Origanum majorana aerial parts against CCl4 induced hepatotoxicity in rats. Materials and Methods: Wistar rats (150-200 g) were divided into five groups each group containing six rats. Group A treated as normal control receives 1% v/v tween-80, p.o for 14 days. Group B received 0.1ml/kg of CCl4 i.p for 10 days which is treated as an experimental control. Group C receives 100 mg/kg of silymarin for 14 days which is treated as standard. Group D and E treated as tests t1 and t2 which receives a methanolic extract of Origanum majorana aerial parts of 200 mg/kg and 400 mg/kg for 14 days respectively. Group C, D, and E were intoxicated with CCl4 (0.1ml/kg i.p) for 10 days 1 h before administration of silymarin and extract. Antioxidant effect of methanolic extract of Origanum majorana was also evaluated by in-vitro antioxidant parameters like hydroxyl and superoxide radicals scavenging activities. The hepatoprotective effect was evaluated...
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