Posted by admin on Apr 30, 2019 in |
Molecular Beacons (MBs) are DNA hairpins that are widely used as fluorescent probes. The inherent signal transduction mechanism let them differentiate between target and non-target oligonucleotides that differ even on a single base. The stem-loop structure consists of donor and acceptor moieties conjugated to both ends thus lying nearby, which leads to FRET. On hybridization to target sequences that hairpin opens up, restoring fluorescence. MBs technology can be applied to a wide range of fields from genetic screening, biochip development, biosensor construction and even mRNA expression in living cells. Recent developments consist of modifications to improve not only the stability of MB in living cells but also lowering signal to noise...
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Posted by admin on Mar 31, 2019 in |
Cancer is the one of the leading cause of death worldwide. Even though many treatments exists in treating and controlling the progression of the deadly disease cancer, yet important inadequacy for development remain. Several undesired side effects occur when cancer is treated using chemotherapy. Therapies of Mother Earth, that utilizes bioactive products derived from a plant in treating cancer, may lessen the side effects. North-East India is recognized as a rich ethnomedicinal asset. It contributes to the abundant reservoir of plant diversity and is recognized as one of the ‘biodiversity hotspots’ of the world reinforcing around 50% of the country’s biodiversity. There has been an increasing frequency of occurrence of cancer in developing countries like India, Nepal, and Pakistan which has serious implications on the morbidity and mortality in millions of people. Most of the Himalayan plants that have been reported are biologically active against different cancer types. The present statistics of cancer chemotherapy is bleak which is why there is an urgent need to develop and discover potent...
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Posted by admin on Feb 28, 2019 in |
Diabetes mellitus (DM), both type I and type II, is a common metabolic disorder worldwide. It is characterized by hyperglycemia, lipid, and protein metabolism abnormalities, and accompanied by several clinical complications including retinopathy, neuropathy, and nephropathy. Many traditional herbs have been used for the treatment of DM. In the present review, we showed a list of these herbs describing their growth area, anti-diabetic properties, their active constituent, and mechanism of action. From the review, the anti-diabetic activity of herbs is largely attributed to the presence of polyphenols, flavonoids, terpenoids, and coumarins. Also, this review strongly suggests these herbs as a natural and safe alternative treatment to the regularly used chemical anti-diabetic...
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Posted by admin on Jan 31, 2019 in |
Polygonum viscosum, belonging to the family Polygonaceae, is an annual herb which is highly distributed in Bangladesh, China, Nepal, Japan, and India. Like any other plant of the genus Polygonum, P. viscosum is significant from both phytochemical and pharmacological properties. Findings regarding the use of this plant in pain, fever, tumor, infection, inflammation, blood clots and so forth mark it as a valuable and noteworthy plant. According to our knowledge, there are very few studies presently available that document all the biological activities of P. viscosum. Hence, the following review gives a critical assessment of the literature to date and is the first review on the mentioned plant combining the limited research data found on Polygonum...
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Posted by admin on Nov 30, 2018 in |
Ulcers are a breach in the mucosa of the alimentary tract that extends through the muscularis mucosae into the submucosa or deeper. They can occur in any portion of the gastrointestinal tract exposed to the excessive amount of acid-peptic juices. Prevalence of peptic ulcer is approximately 11% to 14% for men and 8% to 11% for women during the age of 30 to 50 years. The occurrence of peptic ulcer is very rare above 60 years but produce death in 80% of cases. This review gives an overview of the symptoms, diagnosis, treatment, prevalence, and management of...
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