THE EVOLUTION OF MODERN-DAY DRUGS FROM ‘DROGUE–MILESTONES, SHORTFALLS AND SCOPE FOR REFORMAbstract
The solid drug dosage form, especially the tablet formulations, are made with natural polymer- microcrystalline cellulose (MCC) fibers with many other inorganic agents exclusively to achieve the physical form of the tablet than to enhance the drug efficacy or lowering dosage or frequency of administration. Direct compression is effected directly or after following the procedure of wet granulation. If we explore various digestible fibers from vegetable sources and extract the fibers using the same process as that of MCC, the drug delivery and additional effect of the base can be achieved simultaneously. The review article discusses various ingredients used in tablet formulation and their possible limitations and side effects. Further, the article also elaborates on various physiological, genetic, and tissue-related thrush-holds modifications in the human body viz., tachyphylaxis, tolerance, and other changes towards various drugs, and how such modifications pose an additional challenge in the treatment. Such challenges always compel us to look for newer drug molecules where a simple change in the delivery mechanism armamentarium of the tablet formulation may easily address the issue. Target specific delivery of solid drug formulations, especially tablet formulations can be achieved only through timed release and prolonged drug availability than a sudden gush of the drug when formulated with MCC, followed by rapid metabolism or elimination or accumulation of both the drug and the base. The present review article, step by step, narrates the developmental aspects of tablet formulation, advantages, and limitations. Besides the above descriptive account, a clear goal also authors have set to address the above limitations.
G. V. Amruthavalli * and A. Vijayalakshmi
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, India.
02 December 2021
23 January 2022
27 January 2022
31 January 2022