Posted by admin on Jun 30, 2018 in |
Helminthiasis is prevalent globally, but is more common in developing countries with poorer personal and environmental hygiene. In the human body gastrointestinal tract is the abode of many helminths, but some also live in tissue. They harm the host by depriving him of food, causing blood loss, injury to organs, intestinal or lymphatic obstruction. It is estimated that hundreds of millions of people harbor parasitic worms and one-third of the almost three billion people that live below the poverty line in developing regions of Sub-Saharan Africa, Asia, and the Americas are infected with one or more helminth. This review gives an overview of symptoms, diagnosis, treatment, prevalence, and herbs used in...
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Posted by admin on Jun 30, 2018 in |
Before the advances in synthetic chemistry and discovery of antimicrobials in the 19th early to 21st centuries, plants provided the major source of medicines. Traditional knowledge is more and more an established resource for modern medical science. Ayurveda is the most ancient health care system and is practiced widely in India, Sri Lanka and other countries. This article reviews some of the past success of the natural products approach and also explores some of the reasons why it has fallen out of favour among major pharmaceutical companies and challenge in drug discovery from natural products especially higher plants. In this review we consider the past, present and future value of employing information from plants used in traditional medical practice for the discovery of new bioactive...
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Posted by admin on Jun 2, 2018 in |
Oral delivery of the drug is the preferable drug delivery due to the ease of administration, patient compliance, and flexibility in the formulations. In recent era, various technologies have been made in research and development of controlled release oral drug delivery system to overcome various physiological difficulties such as variation in gastric retention and emptying time. Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from the stomach, especially in case of drugs which are less soluble at alkaline pH of the intestine and locally acting drugs in the stomach get rapidly emptied. So, frequency of dose administration in such cases is increased. Gastro retentive drug delivery system is facing many challenges which can be overcome by upcoming newly emerging approach, i.e., raft forming system. The present study provides valuable information and highlights advances in this raft forming system. Different types of smart polymers used for their formulation have also been summarized. The review focuses on the mechanism, formulation, development, and system optimization aspects...
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Posted by admin on Jun 2, 2018 in |
Thuja orientalis (Commonly- Morpankhi, Family- Cupressaceae) is an evergreen, monoecious trees or shrubs used in various forms of traditional medicines and homeopathy in various ways. In traditional practices, Thuja is used for the treatment of bronchial catarrh, enuresis, cystitis, psoriasis, uterine carcinomas, amenorrhea, and rheumatism. Recent researches in different parts of the world have shown that Thuja orientalis and its active component thujone have the great potential against various health problems. Thuja orientalis preparations can be efficiently used against microbial/worm infection. It can be used as antioxidant, anticancer and anti-inflammatory agent. Instead of these effects, it can also be used as insecticidal, molluscicidal and nematicidal activity against different pests. The present review highlights some important biological properties of Thuja...
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Posted by admin on Jun 2, 2018 in |
Curcumin regulates cellular signaling pathway related to cancer growth, inflammation and apoptosis and due to biological activities can be target DNA, RNA, and enzymes. Also, curcumin has an inhibitory effect against MARK, P53, β-catenin, and AKT. It can be considered as a promising agent to treat many diseases, but it is important that should be acceptably carried out cellular targeting with curcumin. Here, we reviewed the beneficial effects of curcumin in the treatment of diseases. Our review study was confirmed that curcumin has a potential effect in diseases treatment, but there is a dire need for an increase of its bioavailability to the promotion of its efficacy. We suggest that should be design the methods for increase of cellular targeting by curcumin in further...
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