Posted by admin on May 31, 2026 in |
Thrombosis remains a leading cause of cardiovascular morbidity and death, with complications including myocardial infarction and stroke. It is characterized by the development of thrombi, or blood clots, inside blood vessels. Herbal remedies are increasingly being studied as safer, complementary alternatives to conventional thrombolytics like streptokinase. A human blood clot lysis model was used to investigate the in-vitro thrombolytic efficacy of two Bangladeshi polyherbal formulations, Rohitakarishta (Hepatolin) and Sharbat Chylosin (Hepa-10). Ten healthy people’s venous blood samples were placed under incubation at 37°C to cause clot formation. Thrombolytic activity of the formulations was evaluated at 100 µL and 200 µL concentrations using distilled water as the negative control and streptokinase as the positive control. The standard, streptokinase, showed maximum clot lysis (58.52% ± 2.02), while the negative control caused minimal clot lysis (2.8% ± 0.48). At 200 µL, Hepatolin caused the most clot lysis (51.52% ± 0.43), followed by Hepa-10 (42.30% ± 1.64). At 100 µL, the lysis rates of Hepatolin and Hepa-10 were (26.11% ± 2.09) and (24.36%...
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Posted by admin on May 31, 2026 in |
Citrus limon is the commonly available medicinal plant in India. Which is utilized for the various pharmacological and food activities. During this year, commercial production of lemons was approximately 4.3 million tons that harvested from 25734 hectares in Iran. Nowadays, the interest in essential oils and their application in food preservation have been amplified as the natural additives to improve the shelf-life and the safety of food products, due to the risk in using synthetic preservatives. Also, food-borne diseases are a growing public health problem worldwide, calling for more impressive preservation tactics. Lemon has many bioactive components such as citric acid, Ascorbic acid, minerals, flavonoids and essential oils. In present work Citrus limon leaves subjected for extraction and followed by phytochemical Investigation and antimicrobial activity. The result shows that Citrus limon leaves ethanolic extract showing significant antimicrobial activity. The antimicrobial activity of the plant extract will be beneficial for the treatment of various microbial diseases such as fungal infection, skin rashes, ringworm and other skin related...
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Posted by admin on May 31, 2026 in |
This experiment was conducted to determine in-vitro antidiabetic properties of Barleriagibsoni stem extracts based on the inhibition of α-amylase and uptake of glucose by yeast cell models. At varying concentrations, ethanol and aqueous extracts were evaluated and compared to the standard drug Metformin. The two extracts showed a concentration dependent rise in activity, but the ethanol extract always proved to have better inhibitory effects than the aqueous extract. The ethanol extract and the aqueous extract had 75.18 and 64.21% inhibition, respectively, in the glucose uptake assay, as compared to 87.10% inhibition of metformin. It is noteworthy that the ethanol extract had an activity of about 86% of the standard drug, and could be observed with a reasonable activity even at lower levels. The two extracts were moderate in the α-amylase inhibition assay, although the ethanol extract was more effective. Comparative analysis revealed that the ethanol extract was more effective in both assays implying that it is effective in extracting bioactive compounds like flavonoids, phenolics and alkaloids. Moreover, more pronounced...
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Posted by admin on May 15, 2026 in |
A series of novel benzoxazole derivatives (4a–4i) were designed, synthesized, and evaluated for their in-vitro antifungal activity against seven phytopathogenic fungi, including G. saubinetii, T. cucumeris, S. sclerotiorum, V. dahliae, F. oxysporum, P. capsici and F. proliferatum, using the mycelial growth inhibition method. All compounds were initially screened at 100 mg/L, and active compounds were further assessed for EC₅₀ values. The synthesized derivatives showed moderate to excellent antifungal activity, with compound 4g exhibiting the most potent and broad-spectrum inhibition, outperforming standard fungicides mandipropamid and hymexazol. Compounds 4f and 4h also displayed strong activity against selected fungal strains. Structure–activity relationship analysis indicated that halogen substitution significantly influenced antifungal efficacy. The results suggest that benzoxazole-based scaffolds, particularly compound 4g, represent promising leads for the development of new antifungal agents for agricultural...
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Posted by admin on May 15, 2026 in |
Medicinal plants are an invaluable source of bioactive compounds with therapeutic potential. Pedalium murex, commonly known as “Gokhru,” has been traditionally used in Ayurveda for managing urological disorders, reproductive health, and inflammatory conditions. This study aimed to perform a comprehensive phytochemical investigation, extraction, and quantification of bioactive constituents in the hydro-alcoholic extract of P. murex leaves. Organoleptic, physicochemical, and preliminary phytochemical evaluations confirmed the presence of carbohydrates, proteins, flavonoids, glycosides, terpenoids, and phytosterols, while saponins, tannins, and alkaloids were absent. The extract yield was 11.87% w/w, and HPLC analysis enabled the identification and quantification of flavonoids, with quercetin and rutin detected at retention times of 2.597 ± 0.08 min and 7.621 ± 0.53 min, respectively. Method validation demonstrated excellent linearity, precision, accuracy, and sensitivity, indicating the reliability of the developed RP-HPLC method for routine quality control. These findings validate the traditional use of P. murex and establish a scientific basis for its standardization, providing a foundation for the development of herbal formulations and nutraceutical...
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