Posted by admin on Jul 31, 2018 in |
Hypertension is a common clinical problem encountered in day-to-day practice. Although several synthetic pharmaceutical drugs already exist for the treatment of hypertension, these drugs can develop many complicated side effects. On the other hand in our Arabian countries, patient compliance forces the population to frequently recourse to traditional medicine which mainly uses plants. Because of most of the medicinal agents including herbs were reported to have potentially unexpected effects including toxicity and interactions, this study focused on the investigation of antihypertensive activity of four plants mixture along with studying their interaction. In this study ethanolic extract of a mixture composed of four plants Hyphaene thebaica, Olea europaea, Origanum majorana, and Hibiscus sabdariffa was investigated for its antihypertensive activity and interaction between it’s including herbs. 50 g of each plant powder was mixed homogeneously and macerated in 70% ethanol for about 7 days. The effect of this extract was investigated at a dose level of 25 mg/kg. Blood pressure was measured by a non-invasive blood pressure recorder apparatus before and...
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Posted by admin on Jun 30, 2018 in |
The aim of the present work was to investigate the anti-diarrheal and diuretic potentials of Tabernaemontana divaricata Linn. leaves of the family Apocynaceae. In almost all tropical developing countries of the world, diarrhoea is one of the most common and serious diseases, the principal cause of morbidity and mortality among children under five years. The methanolic extract of the leaves of T. divaricata L. was evaluated for anti-diarrheal properties in castor-oil induced diarrhoea. In the castor oil induced diarrhoea, MELTD significantly inhibited the number of defecations. The diuretic activity of the methanolic extract of leaves of T. divaricata (MELTD) was assessed based on Lipschitz value and diuretic index. The standard diuretic drug furosemide exhibited a significant increase in the urinary excretion of water and electrolytes (Na+ and K+), which is comparable with the extract. The diuretic index at the dose of 200 mg/kg (MELTD) was calculated as 1.55, significant as compare to the standard drug having a diuretic index of...
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Posted by admin on Jun 30, 2018 in |
Ficus polita leaves have been used in traditional medicines to increase physical strength, work productivity and longevity, resistance to high altitude sickness, fatigue, depression, anemia, gastrointestinal ailments, infections, and nervous system disorders. The objective of this study was to evaluate the analgesic activity of hydromethanolic extract of F. polita leaves in rats using acetic acid-induced writhing and tail flick immersion methods. The phytochemical screening of the extract revealed the presence of flavonoids, saponins, terpenoids, glycosides, resins, steroids, balsams and pholobatannins. Acute oral toxicity study resulted in no mortality after oral administration of 3000 mg/kg of the extract. Based on the tail flick immersion test, Ficus polita hydromethanolic leaves extract and the standard drug, diclofenac showed significant (P<0.05) analgesic activity by prolonging the mean latency time when compared to the control. However, a significantly (P<0.001) prolonged mean reaction latency to pain in morphine-treated groups was not comparable to the extract and diclofenac treated groups. The extract and the standard drugs significantly (P<0.001) inhibited the acetic acid-induced abdominal writhing at all...
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Posted by admin on Jun 30, 2018 in |
Trichosanthes cucumerina var. cucumerina Linn. is an annual monoecious climber. Trichosanthes cucumerina var. cucumerina Linn. mainly distributed in Asian countries like India, Sri Lanka, Bangladesh, Burma, Malaysia, and Australia. Trichosanthes cucumerina var. cucumerina is a wild variant (Cucurbitaceae) the major active components are triterpenoids, saponins, and cucurbitacins; chemical constituents like flavonoids, carotenoids and phenolic acids are also present. Trichosanthes cucumerina var. cucumerina is used in the treatment of headache, alopecia, fever, abdominal tumors, bilious, boils, acute colic, diarrhea, haematuria, and skin allergy, etc. Trichosanthes cucumerina is used as an abortifacient, vermifuge, refrigerant, purgative, malaria, laxative, hem agglutinant, emetic, cathartic, bronchitis and anthelmintic. The present study involves the pharmacognostical and phytochemical studies of the plant. The transverse section was taken for the microscopical studies. Powder microscopy shows the presence of annular, spiral, cylindrical, tubular and thick-walled xylem vessels. Different physicochemical evaluation ash value, extractive value, fluorescence analysis, etc, were performed. Phytochemical evaluation is performed for the ethanolic extract of leaves presence of alkaloids; flavanoids, glycosides, phenols, etc. are...
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Posted by admin on Jun 30, 2018 in |
The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study, we have isolated three compounds (LC1-3) by chromatographic methods from the mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as Kaempferol-3, 7-di-O-α-L-rhamnopyranoside (LC1), 7, 4’- dihydroxy-5, 3’- dimethoxyflavone (LC2), (S)-5, 5’, 7-trihydroxy-2’, 4’-dimethoxy-6-methylflavanone (LC3). Their structures were elucidated by spectroscopic methods, including MS and NMR. Compound LC3 was isolated from mulberry leaves for the first time. These compounds were evaluated the tyrosinase inhibitory activity in-vitro. Our data showed that compound LC3 has potential tyrosinase inhibitory effects with IC50 values of 15.48 ± 2.96...
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