Posted by admin on Aug 31, 2018 in |
The qualitative estimation of herbal formulation Lohasava, is of principal importance to justify their adequacy in the present system of medicine. One of the key problems which are faced by the herbal drug industry is the unavailability of rigid quality control profiles for herbal materials and their formulations. Regulatory bodies have such as WHO, AYUSH, ICH, etc., had laid down the standardization and specifications parameters for various Ayurvedic preparations. The present Investigation evaluated different brands of Lohasava available in the market as per WHO and Indian Pharmacopoeial specifications. Various physicochemical parameters such as Loss on drying, total ash, sugar content, alcohol content, and microbial content were determined. The result reveals that all the preparations contain acceptable levels of alcohol (less than 12%...
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Posted by admin on Aug 31, 2018 in |
Cytotoxicity of lipopolysaccharide (LPS) as a bacteria-related compound and paraquat (PQ) as a non-bacterial toxicant on freshly isolated alveolar macrophages (AMs) was studied. At the same time, preventive, protective and therapeutic effects of quercetin (QCN) against LPS-induced and silymarin (SMN) against PQ-produced cytotoxicity as known antioxidants with potent anti-inflammatory property were also investigated. Freshly isolated rat’s AMs were exposed to low, medium and high concentrations of LPS (1, 5 and 10 µg/ml), PQ (1, 5 and 10 µg/ml), QCN (1, 5 and 10 µg/ml) and SMN (25, 50 and 100 µg/ml), separately. After that, the effective concentration of LPS/PQ along with low, medium and high concentrations of QCN/SMN in the forms of preventive, protective and therapeutic was evaluated on cell viability, lactate dehydrogenase activity (LDH), nitric oxide content and total antioxidant capacity (TAC) of alveolar macrophages. Results showed that both LPS and PQ in a concentration-dependent manner reduced the cell viability and TAC values and elevated the NO content and LDH concentration. By contrast, QCN and SMN administration alone...
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Posted by admin on Aug 31, 2018 in |
Antibiotic resistance is one of the biggest threats to global health, food security, and development today. Medicinal plants have historically proven their value as a source of molecules with therapeutic potential. The interest in natural product-based drug discovery has revitalized in recent years because synthetic compound libraries and high throughput screening for discovery of new drug leads did not meet the expectations. The aim of this study is to systematically review the use of Jordanian medicinal plants then identify the most attractive plant for the discovery and development of drugs against resistance Staphylococcus aureus and Pseudomonas aeruginosa based on data collected from previous studies, that investigate the inhibitory effects of methanolic extracts of 8 Jordanian plants and their combinations with three antibiotics, on resistance of Staphylococcus aureus and Pseudomonas aeruginosa and studies that collected information from local population concerning the use of medicinal plants in Jordan. The results suggested that Artemisia herba-alba used in Jordan as traditional medicine has been reported to have a significant effect against the resistance...
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Posted by admin on Aug 31, 2018 in |
This study was designed to determine the acaricidal effect of Datura stramonium, Nicotiana glauca and Azadirachta indica herbal extracts against the common cattle tick Boophilus decolratous. Qualitative phytochemical analysis using standard techniques was also used to detect secondary metabolites contained in the selected herbs. The percent adult mortality and percentage inhibition of oviposition were studied at different experimental concentrations of 25, 50, 75 and 100 mg/ml to determine the efficacy of leaf extracts. 3% of dimethyl sulfoxide was also used as a negative control. The study determined the presence of secondary metabolites in the herbal leaf extracts, which can cause neurotoxicity in a tick. Inhibition of oviposition at the highest concentration of Datura stramonium, Nicotiana glauca and Azadirachta indica of the treated ticks were 78.68, 86.84 and 52.63%, respectively. At the highest concentration, the adult tick mortality was 90, 100 and 80% for Datura stramonium, Nicotiana glauca and Azadirachta indica, respectively. The results of the current study pointed out the potential acaricidal effect of selected medicinal plants with varying...
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Posted by admin on Aug 31, 2018 in |
Objective: This study was designed to extract, purify and determine the phyto-components in the petroleum ether extract of Irvingia gabonensis seeds (IGS). A multiple batch extraction procedure was employed using petroleum ether as a solvent. A specified quantity of the IGS was size reduced, dispersed in freshly distilled water by heating to a temperature of 80 ºC. The dispersion was then filtered through a clean muslin cloth. The fats content was separated from the Biopolymer by first dispersing in 90% alcohol, filtered and dried at 40 ºC. The fat component of the residue was finally extracted with petroleum ether. The GC-MS analysis of the petroleum ether extract of IGS was performed using an Agilent G1701 GC/MSD system. This investigation was done to determine the possible chemical components from IGS by GC-MS. This analysis revealed that the petroleum ether extract of IGS contained mainly fatty acid compounds–lauric acid (36.82%), myristic acid (31.52%), benzyl dodecanoate (9.06%) and palmitic acid (4.03%), n-Decanoic acid, 1-(hydroxyl-methyl)- 1, 2- ethanediyl ester, tetradecanoic acid, 2- hydroxy-1,...
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