Posted by admin on May 31, 2019 in |
Amaranthus spinosus, belongs to Amaranthaceae family, is an annual or perennial herb grows annually; native to tropical America and found throughout India as a weed in cultivated as well as fallow lands. Though the whole plant is used as a laxative, the roots are regarded as highly specific for colitis, and it is also used as antipyretic, febrifuge, diuretic. Other than its culinary value, it is utilized in the treatment of bronchitis, digestible, appetizer, biliousness, haematinic, galactagogue, stomachic, flatulence, nausea, anorexia, blood diseases, leucorrhoea, burning sensation, leprosy, and piles. This study aimed to investigate the anti-nociceptive activity of the ethanol extract of the root of Amaranthus spinosus Linn. The anti-nociceptive activity was investigated for its peripheral and central pharmacological action using acetic acid-induced writhing, hot plate, and tail immersion methods in Swiss albino mice at the doses of 200 and 400 mg/kg body weight. Ethanol extract of the root (200 and 400 mg/kg) showed the most significant anti-nociceptive activity in acetic acid induced writhing method with writhing inhibition of...
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Posted by admin on May 31, 2019 in |
The improvisation of any system has been a challenging task for the scientist in the field of drug delivery. In pursuit of the stable carrier system, here the microemulsion or other meta-state like liquid crystal phase with the specific mechanism, i.e., “six-member stable cyclic system” is highlighted and critically evaluated. The system with co-surfactant (propylene glycol) is examined and concluded with the plausible mechanism of hydrogen bond donor/acceptor felicitator to the surface active molecule by the hydrogen bonding with the surfactant polar head group to increase the fluidity of the system. Through this unique mechanism, the co-surfactant expands the area of existence of microemulsion. The system allows the topical drug with the stable as well as a flexible system with higher drug entrapment. The systems aligned toward the liquid crystal phase than the liquid phase, which makes the system more convenient for the delivery...
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Posted by admin on Apr 30, 2019 in |
The plant Withania somnifera has many acclaimed medicinal uses. This work aims to explore the efficacy of the aqueous extract (AE) of W. somnifera on the isolated trachea and aorta rings, perfused heart, blood pressure and diuresis in rats. Phytochemical analysis of the whole plant of W. somnifera was carried out using standard extraction procedures followed by column chromatography. An aqueous extract (AE) was also prepared by boiling the whole plant material in water followed by evaporation under reduced pressure. The smooth muscle relaxant effect of AE of W. somnifera (10-4 – 3×10-1 mg/mL) was tested on isolated rat tracheal and aortic rings. The effect of AE on heart rate and contractility of the isolated perfused heart were recorded. The hypotensive effect of AE (0.4-120 mg/kg) was recorded from the carotid artery in anesthetized normotensive rats. The diuretic activity of AE was evaluated in rats at two different doses (800 and 1600 mg/kg), and urine volume was measured throughout 24 h. Phytochemical analysis of the Jordanian locality of W....
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Posted by admin on Apr 30, 2019 in |
The present investigation was directed to assess the counter lithiasis action of ethanolic concentrates of entire plant of Bryophyllum pinnatum. Urolithiasis is an infection brought about by the nearness and impacts of uroliths (stones) or calculi or exorbitant measures of precious stones in the urinary tract. The illness is alluded to by numerous names, including cystitis, urethritis, urinary calculi, bladder stones, or kidney stone. Ethanolic concentrate of the plant of Bryophyllum pinnatum was exposed to antilithiatic action in rodents where Ethylene glycol (0.75 (v/v)) utilized as the causing lithiasis specialist. A stamped ascend in calcium, oxalates, phosphorus, and creatinine in blood serum level saw in lithiasis (100 and 200 mg/kg) displayed a portion subordinate critical enemy of lithiasis action on treatment. The concentrate portion of 300 mg/kg likewise caused fractional instruction of calcium, oxalates, phosphorus, and creatinine in blood serum level the outcomes were discovered factual irrelevant. The antilithiatic impact of ethanol separate was discovered compelling with that reference...
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Posted by admin on Apr 30, 2019 in |
Aim: The present research aims to screen anabolic activity on bone formation and bone density in normal and Teriparatide (Rh PTH biosynthetic human parathyroid hormone 1-34) induced inhibition of osteogenesis in zebrafish larval model to alleviate osteoporosis and other bone and joint disease or disorders of the Nano encapsulated essential oil isolated from the Ruta graveolens (NELVORG) Family: Rutaceae using a novel, fast, economical and genetically tractable method for screening developmental aspects of bone formation in a high throughput fashion through the visualization of embryonic and larval skeleton of zebrafish (Danio rerio) model. Method: The volatile oil (VO) was isolated from the leaves of R. graveolens and extracted VO was subjected to GC-MS Analysis. The nano-encapsulated volatile oil of R. graveolens leaves (NELVORG) was prepared by solvent displacement method, and particle size was standardized by scanning electron microscope (SEM). We implemented 3Rs (Reduction, Replacement, Refinement) ethical principle to minimize harm to the vertebrate animals. Preliminary toxicological studies were evaluated on whole embryo and larvae, showed no mortality up to...
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