PHYTOCHEMICAL ANALYSIS AND IN-VIVO SCREENING OF PSEUDODRYNARIA CORONANS (WALL. EX. METT.) CHING ON ITS ANALGESIC AND ANTI-INFLAMMATORY PROPERTIESAbstract
The methanolic rhizome extract of Pseudodrynaria coronans (MEPC) was assessed for its preliminary phytochemical constituents, anti-nociceptive and anti-inflammatory activity. Acute toxicity of the extracts was tested following the OECD – 425 guidelines and after giving MEPC at the dose of 2000 mg/kgb.w indicating that the LD50 is higher than the given dose. Two doses 200 and 400 mg/kg bw. were selected for all the experiments. Hot plate and Tail immersion methods showed that the extract was statistically significant (p<0.05 and p<0.01). Different concentrations of the MEPC showed significant inhibition of protein denaturation and membrane stabilization. Also, the MEPC exhibited significant inhibition of carrageenan-induced paw oedema (p<0.01) and cotton pellet-induced granuloma (p<0.05 & p<0.01) inflammatory responses in the rats.
K. Elu, P. K. Roy, P. Lapasam, C. Lalnunfela, H. Lalhlenmawia, Y. Umbon and T. C. Lalhriatpuii *
Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences, Zemabawk, Aizawl, Mizoram, India.
20 April 2021
24 May 2021
26 May 2021
31 May 2021