Posted by admin on Jun 30, 2021 in |
Objective: Ariel part of Opuntia elatior (Cactaceae) has been used in folklore health systems to treat diabetes in America, Mexico, and India. However, the anti-diabetic potential of cladodes of this medicinal plant is not scientifically validated and authenticated. The present study aimed to evaluate in-vitro and in-vivo anti-oxidant and anti-diabetic potential of methanol extracts and solvent fractions of O. elatior cladodes. Methods: The methanol extracts and solvent fractions of Opuntia elatior cladodes were evaluated at different concentrations (12.5-400 µg/ml) for anti-oxidant activity by using DPPH method and different doses (200 and 400 mg/kg body weight) for anti-diabetic potentials in staptozotocin induced diabetic albino rats. The extracts were administered for three weeks in different groups. Results: The acute toxicity study of Opuntia elatior cladodes extract, and fractions did not show mortality in the animals at the limit dose of 2000mg/kg during the observation period. The outcome of the present study indicates that extract and different fraction shows potential anti-oxidant activity. Cladodes also extract significantly decreases elevated level of blood glucose...
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Posted by admin on May 31, 2021 in |
Objective: Stem Bark, Root, and fruit of Ziziphus oenoplia (Rhamnaceae) has been used in traditional health systems to treat diabetes and many more disorders in southern Asia as India, Sri Lanka, and Burma. However, the anti-oxidant and hypoglycemic potential of the fruit of this valuable plant is not scientifically validated till date. The aim of the present study is to evaluate in vitro free radical scavenging and hypoglycemic effect of ethanol extracts and solvent fractions of Ziziphus oenoplia fruit. Methods: The ethanol extracts and three solvent fractions of Ziziphus oenoplia fruit were evaluated at different concentration (20- 640 µg/ml) for free radical scavenging activity by using in-vitro DPPH method and different concentration (25-800 µg/ml) for hypo-glycemic potentials by using α – glucosidase and α-amylase enzymes (intestinal enzymes which slow the digestion of carbohydrates and delay glucose absorption) inhibitory activity. Results: The outcome of present study indicates that maximum anti-oxidant activity was produced by ethanol crude extract (87.66±1.54% Inhibition at 640 μg/mL) with IC50 value 2.72±0.62 followed by chloroform fraction...
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Posted by admin on May 31, 2021 in |
The methanolic rhizome extract of Pseudodrynaria coronans (MEPC) was assessed for its preliminary phytochemical constituents, anti-nociceptive and anti-inflammatory activity. Acute toxicity of the extracts was tested following the OECD – 425 guidelines and after giving MEPC at the dose of 2000 mg/kgb.w indicating that the LD50 is higher than the given dose. Two doses 200 and 400 mg/kg bw. were selected for all the experiments. Hot plate and Tail immersion methods showed that the extract was statistically significant (p<0.05 and p<0.01). Different concentrations of the MEPC showed significant inhibition of protein denaturation and membrane stabilization. Also, the MEPC exhibited significant inhibition of carrageenan-induced paw oedema (p<0.01) and cotton pellet-induced granuloma (p<0.05 & p<0.01) inflammatory responses in the...
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Posted by admin on May 31, 2021 in |
Objective: To investigate the Pharmacognosy as well as the Antioxidant, Anti-inflammatory potential of the Katha powder. Methods: The Coarsely dried chips of Acacia catechu heartwood were treated with 10% hydro-alcoholic solution to obtain Katha as the final product. The powdered Katha was standardized via pharmacognostic parameters. This Kathapower is showing good solubility in hot water, having astringent in the taste. The powder microscopy of the Katha powder is to be demonstrated fragments of acicular crystals, fibers and bordered pitted vessels. Katha powder antioxidant potential is to be accessed by using the DPPH assay and NO Scavenging assay by using ascorbic acid as a standard drug. Further, the Katha powder is to be subjected for the assessment of its anti-inflammatory potential by use of Heat-induced hemolysis as well as the Hypotonicity-induced hemolysis approach by the use of aspirin or diclofenac sodium as a standard drug. Results: Microscopical investigations were showed that Katha showing the presence of fragments of acicular crystals, fibers, and bordered pitted vessels. In-vitro study shows that the...
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Posted by admin on May 31, 2021 in |
The spread of infectious diseases in the world is a major challenge for health institutions and pharmaceutical industries. The current trends of multi-drug resistance to the available synthetic drugs or antibiotics among emerging and re-emerging bacterial pathogens lead to serious risks. It is therefore necessary to search for new antimicrobial agents that are better, cheaper and without side effects for treating these infectious diseases, especially in developing countries. In this study, phytochemical composition and antimicrobial activities of aqueous and methanol extracts of stem-barks of Mangifera indica were investigated. Standard methods were employed to screen for the presence of phytochemicals. Agar well diffusion method was used to determine the antimicrobial effects of aqueous and methanolic extracts of M. indica stem-bark against selected bacterial (Shigella sp, Staphylococcus sp, Escherichia coli, Vibrio sp) and fungi (Penicillium sp, Yeast, Mould) isolates. Phytochemical results showed the presence of active pharmacological components such as tannins, saponins, glycoside, flavonoid, terpenoid, alkaloids, and steroid. Methanol extract demonstrated the highest activity of bacterial (Staphylococcus sp with 15.4 ±...
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