Posted by admin on Aug 31, 2024 in |
The aim of this study is to prepare and formulate an herbal shampoo and evaluate its physiochemical properties for safety and efficacy which contain safe natural ingredients. Shampoo is a hair care product used for the removals of dirt, oils, skin particles, environmental pollutants and other foreign particle which build up in hair. The shampoo is enriched with herbal extract without any synthetic additives. The herbal extract used in formulations are Punica grantum (pomegranate), Curcuma longa (turmeric), Sapindus mukorossi (ritha), Datura metal (datura), Pisidium guajira (guava), Azadinachta indica (neem), Hibiscus rosa-sinensis (shoe black plant), Citrus sinensis (orange), Zingiber officinale (ginger), Allium sativum (garlic), Allium cepa (onion), Cuminum cyminum (jeera). Herbal shampoo was prepared by simple mixing process. The herbal shampoo was tested for physicochemical properties. Some of methods are visual inspection, pH determination, solubility check, cleansing action, determination of percentage solid content, viscosity evaluation, dirt dispersion, foaming ability detergency ability and stability...
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Posted by admin on Jul 31, 2024 in |
In Ivory Coast, the leaves of Ipomoea batatas are consumed like spinach without any prior study of toxicity. This study aims to evaluate the toxicity of Ipomoea batatas leaf macerate on female rats. Thus, the phytochemical screening, the acute oral toxicity test of the leaf macerate of this plant was carried out on female rats. The results show that Ipomoea batatas leaves contain sterols and polyterpenes, polyphenols, flavonoids, alkaloids and saponosides. The study also reveals that the macerate of I. batatas leaves is not toxic orally. The rats showed no signs of toxicity. The weight of vital organs of female rats treated with the macerate showed no significant difference from that of control female rats. Concerning the reproductive organs, a significant increase in the weight of the ovary was observed in females’ rats treated with the extract compared to control rats. The study revealed a decrease in the level of white blood cells in the test female rats. At level of biochemical parameters, a significant decrease in AST and...
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Posted by admin on Jun 30, 2024 in |
Diabetes, a silent killer, ravages the kidney and liver, leaving a trail of destruction in its wake. Studies have suggested a link connecting dysfunctional liver and renal activity alongside glucotoxic retinopathy in patients of type 2 diabetes mellitus. Against this background, our preclinical study unveils the remarkable nephro-hepatoprotective effects of herbal teas from Hibiscus sabdariffa, Moringa oleifera, Zingiber officinale and Azadirachta indicain diabetic male Wistar rats induced with alloxan. Diabetes of artificial source was administered through a one-time interperitoneal administeration of about seven categories having 6 rats in the individual group. control (glycemic), diabetic groupthat is made up of alloxan treatment + Zobo (100+400 mg/kg)., alloxan + moringa (100 +200 mg/kg), alloxan + ginger (100+500 mg/kg), alloxan + Dogoyaro (100+250 mg/kg), and lastly, the alloxan +glibenclamide (100+5mg/kg) were orally given for 28 days. Reduction of tissue weight was observed upon administration of alloxan which was ameliorated upon treatment with the selected herbal teas. Also, elevated levels of liver and kidney biomakers induced by alloxan were reversed upon administration of...
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Posted by admin on May 31, 2024 in |
In the present study, an attempt was made to investigate Pharmacognostical studies on the stem bark of Annona glabra (Annonaceae). The plant was identified and authenticated by Dr. V. Rama Rao, Research officer (Botany), Central Ayurveda Research Institute, Bengaluru. The macroscopical studies have been carried out on the stem bark. The Characters of transverse section of stem bark shows periderm, consisting of 3-4 layers of cork, 2-3 layers of phellogen and 6-7 layers of Phelloderm. The cortex region shows the presence of parenchymatous cells. Group of fibres in patches in the outer and inner cortex. The secondary cortex consists of moderately thick-walled, parenchymatous cells. Medullary rays were present, these are bi, tri or multiseriates in the region of the inner secondary phloem. Starch grains are present. The longitudinal section shows multiseriate ray initials and single, long, septate fusiform initials, ends are arranged at different levels fusiform initials or non-stratified cambium. Starch grains are also present in the parenchyma cells. Powder shows reddish brown in colour, fragments of parenchymatous cells...
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Posted by admin on May 31, 2024 in |
In this study, Pleurotus ostreatus polysaccharide (POP) is isolated, refined, structurally analysed, and its anticancer properties are investigated. Polysaccharide yield was 6.27%, purified via DEAE-52 and Sephadex S-300 chromatography, with a molecular weight of 154649.8 Da. Structural analysis through FT-IR, HPLC, GC-MS, and NMR revealed POP as a homopolysaccharide composed of D-glucose units, featuring (1→6)-α-D-Glcp backbone with O-6 branches and T-α-D-Glcp terminations. These findings contribute to understanding the biological potential of POP. POP’s antitumor activity study showed that, with an IC50 of 121.801 µg/mL, it was highly cytotoxic to EAC cell types, supported by LDH release analysis. POP inhibited cell migration, invasion, and colony formation, indicating its potential as an anti-cancer agent. Analysis using flow cytometry showed that POP induced apoptosis, which raised the expression of Bax and Caspase-9 while decreasing the expression of Bcl-2. DNA fragmentation assay showed characteristic laddering pattern, confirming apoptosis-mediated DNA degradation. Furthermore, alterations in the expression of the proteins p53, Cyclin D, and Cdk4 were linked with POP-induced cell cycle arrest in the G0/G1...
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