FORMULATION AND EVALUATION OF TOPICAL GEL CONTAINING ECONAZOLE NITRATE
AbstractThe purpose of this work was to develop a novel topical formulation of econazole nitrate based on gel that can be easily scaled up in one pot for the potential treatment of fungal and yeast infections. Econazole nitrate is a topical antifungal, used to treat tinea versicolor, tinea pedis, and tinea cruris. Compared to applying cream or ointment, topical gels offer numerous advantages, one of which is that the drug is released more quickly to the intended site of action. A viscous mixture of propylene glycol, Triethanolamine, methyl paraben, and econazole nitrate were mixed together before being formulated into the optimized gel bases. The gel’s color, appearance, and homogeneity were assessed visually. For every formulation, the drug content, pH, viscosity, spreadability, and gel strength were characterized. The manufactured formulations were transparent, half white, pale yellow, and exhibited excellent homogeneity. The pH and viscosity are within the limit. The drug diffusion of F1 93.81, F2 97.56, F3 92.36, F4 90.95, F5 93.18 and F6 90.14. From among all the developed formulations, F2 shows better drug diffusion that is 97.56.
Article Information
8
636-640
604 KB
52
English
IJP
Priyanka G. Raj *, A. R. Ranjeetha, K. S. Aishwarya, M. S. Ananya and N. K. Anjana
Depatment of Pharmaceutics, Bharathi College of Pharmacy, Bharathinagara, Maddur Taluk, Mandya, Karnataka, India.
priyankarajg95@gmail.com
12 October 2024
22 November 2024
26 November 2024
10.13040/IJPSR.0975-8232.IJP.11(11).636-40
30 November 2024
Download