FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET CONTAING METOPROLOL TARTRATE
AbstractIn the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including Bulk density, Tapped density, Angle of repose, Carr’s index, Hauser’s ratio, weight variation, hardness, friability, in-vitro dispersion time, drug content water absorption ratio, wetting time, in-vitro drug release. The tablet prepared by the direct compression method had a weight variation in the range of 198mg to 204mg which is below ±6.5%, Hardness of 3.7kg/cm2 to 4.3kg/cm2 , Percentage friability of 0.56% to 0.61%, in-vitro dispersion time of 18 sec to 24 sec, Wetting time of 33 sec to 51 sec and in-vitro drug release of 45.04% to 97.63% within 15 min. Fast dissolving tablets of metoprolol tartrate have enhanced dissolution and will lead to improved bioavailability and more effective therapy. The release rate of drugs from fast dissolving tablets intensifies with a rise in the concentration of super disintegrants and the metoprolol tartrate formulations reaches the peak levels.
Article Information
5
609-616
661 KB
46
English
IJP
Priyanka G. Raj *, A. R. Ranjeetha, G, Bhavya, M. G. Harsha Vardhana and H. U. Jashwanth Gowda
Department of Pharmacuetics, Bharathi College of Pharmacy, Bharathinagara, Maddur Taluk, Mandya, Karnataka, India.
Priyankarajg95@gmail.com
12 October 2024
22 November 2024
26 November 2024
10.13040/IJPSR.0975-8232.IJP.11(11).609-16
30 November 2024
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