Posted by admin on Apr 30, 2021 in |
Anaemia globally affects 1.62 billion peoples in the world. To treat anaemia, Hibiscus acetosella is sometimes used traditionally. This study has been conducted to evaluate the anti-anaemic effects of the aqueous leaves extract of Hibiscus acetosella, on two experimental models of anaemia. Bleeding anaemia was induced by retro-orbital puncture of 2-2.5 mL of blood during two days, while haemolyticanaemia was induced by intra-peritoneal injection of 2. 4 dinitro-phenylhydrazine (40 mg.kg bw) during 7 days. After induction, plant extract (100; 200 or 400 mg.kg bw) was daily administrated by oral route for 14 days. During experience, haematological analysis was done at the beginning, at the end of induction and every week during treatment. During haemolytic anaemia; aqueous extract significantly increased haematocrit and red blood cell with the maximum of 45% and 32% respectively at the dose of 400 mg.kg.bw; haemoglobin significantly increased in rats with a maximum of 32% at the dose of 200 mg.kg bw. In bleeding anaemia model, H. acetosella significantly increased the haematocrit as well as red...
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Posted by admin on Apr 30, 2021 in |
Six phenolic acids -chlorogenic acid (1), caffeic acid (2), 4,5 di-O-caffeoylquinic acid (3), 3,5 di-O-caffeoylquinic acid (4), 3,4 di-O-caffeoylquinic acid (5) and 3,4,5-tri-O-caffeoylquinic acid (6) were identified by HPLC-UV-MS from the roots of Cephalaria gigantea (Dipsacaceae) growing in Georgia. The aim of the present research was a qualitative identification of phenolic constituents in an anticonvulsive enriched fraction from the roots of C. gigantea, for further quantitative standardization. The HPLC profile demonstrated a good resolution of phenolic acids of the active extract within 25 min of gradient mode (ACN 5% to 40%). On the basis of retention times, using the UV and MS spectra of the corresponding standards, compounds 4 and 5 were found to be majors in the analyzed fraction and were reported for the first time from C. gigantea roots. These experimental data could be a solid base for the future quantitative standardization of the anticonvulsive fraction for the prevention and treatment of psychosomatic forms of...
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Posted by admin on Mar 31, 2021 in |
Aim: To investigate the hepatoprotective activity of Morus alba Linn. alcoholic leaves extracts against paracetamol-induced hepatitis in rats. Materials and Methods: The Morus alba leaves extracted with alcoholic (ALE), and water extract (AQE) against Paracetamol induced hepatotoxicity and using Standard drug is Liv-52. Preliminary phytochemical tests were done. Results: The ALE showed presence of alkaloids, flavonoids, carbohydrates, tannins, and steroids, did not produce any mortality. Paracetamol produced significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP) and serum bilirubin.), histological (damage to hepatocytes) using Standard drug Liv-52. Pre-treatment with ALE extract significantly prevented the biochemical and histological changes induced by Paracetamol in the liver. Conclusion: The present study shows that the ALE extract possessed hepatoprotective activity....
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Posted by admin on Mar 31, 2021 in |
Stereospermum kunthianum Cham. is a small, to medium-sized tree, sometimes only a small shrub. Bark grey, smooth, sometimes flaking, revealing pale under bark. In Senegal this plant is used in traditional medicine against gastritis, asthenia, respiratory diseases but also as a wound healing. The present study was taken up to research an anti-bacterial activity in the trunk bark hydro-ethanolic extract and its fractions obtained by using different solvents. Extract and fractions were tested on clinical strains and reference strains of four bacteria: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis. The methods of diffusion in agar medium and micro-dilution in liquid medium were used. The results showed that on clinical strains, the lowest Minimum Inhibitory Concentration: MIC (0.156 mg/ml) was observed with the hydro-ethanolic extract and its aqueous fraction on Pseudomonas aeruginosa. With regard to the reference strains, the best activity was noted with the aqueous fraction with a MIC of 2.5 mg/ml on the Pseudomonas aeruginosa strain ATCC 27853. However, the standard antibiotics used are more effective...
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Posted by admin on Mar 31, 2021 in |
Raw herbal samples used in the herbal medicine industry need to be properly identified for use in an herbal preparation. Plant parts of Woodfordia fruticosa (L.) Kurz belonging to the Lythraceae family, apart from some commercial uses, is known for its medicinal value in ethno medicines and various Indian traditional medicine systems, including Ayurveda. Flowers are reported high trade value (2000-5000 MT), are used in some Ayurvedic formulations such as Atisara, Raktapitta, Trsna, Vrana, Visarpa, Arjunarishta (Parthadyarishta), and Partharishtam. The present study aimed at botanical characterization and identification of raw leaf, flower, and stem bark herbal samples of Woodfordia fruticosa. Macroscopic and microscopic characters were studied using stereomicroscope and compound microscope. The morpho-anatomical description was provided for flower, leaf, and stem bark samples. Anatomical study of a leaf with a crescent-shaped vascular bundle, three different types of trichomes, and bark with linearly arranged rosette crystals crossing uniseriate medullary rays longitudinally were observed as characteristic features. Powder organoleptic and microscopic characters were described for each studied herbal sample. Characters compiled...
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