Posted by admin on Apr 30, 2021 in |
Alzheimer’s syndrome/disease is known for its progressive Neuro-degenerative illness and considered pathologically by the deposition of β-amyloid peptide and senile plaques (a pathological accumulation of paired helical filament composed of abnormally formed tau protein in the hippocampus of our brain). This serves to maintain the memory deterioration. Along with that, the treatment and prevention of synthetic drugs having a long list of adverse effects. Alzheimer’s syndrome induced through aluminium trichloride (4.2 mg/kg intraperitonial) continues for 28 days. The albino Wistar rats were divided into 5 groups (n=6 in each group) then weighed for 28 days of induction of disease. Extract of dried leaves of Camellia sinensis. (200 mg/kg and 400 mg/kg) along with standard drug (Donepezil 2 mg/kg) by oral route given through (1% CMC suspension) after treatment showed a significantly decreased escape latency. Previous studies for Camellia sinensis showed that it is efficient in the prevention of deposition of senile plaques. Along with neurofibrillary tangles in the hippocampus with deficits in enhanced memory...
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Posted by admin on Apr 30, 2021 in |
Anaemia globally affects 1.62 billion peoples in the world. To treat anaemia, Hibiscus acetosella is sometimes used traditionally. This study has been conducted to evaluate the anti-anaemic effects of the aqueous leaves extract of Hibiscus acetosella, on two experimental models of anaemia. Bleeding anaemia was induced by retro-orbital puncture of 2-2.5 mL of blood during two days, while haemolyticanaemia was induced by intra-peritoneal injection of 2. 4 dinitro-phenylhydrazine (40 mg.kg bw) during 7 days. After induction, plant extract (100; 200 or 400 mg.kg bw) was daily administrated by oral route for 14 days. During experience, haematological analysis was done at the beginning, at the end of induction and every week during treatment. During haemolytic anaemia; aqueous extract significantly increased haematocrit and red blood cell with the maximum of 45% and 32% respectively at the dose of 400 mg.kg.bw; haemoglobin significantly increased in rats with a maximum of 32% at the dose of 200 mg.kg bw. In bleeding anaemia model, H. acetosella significantly increased the haematocrit as well as red...
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Posted by admin on Apr 30, 2021 in |
Six phenolic acids -chlorogenic acid (1), caffeic acid (2), 4,5 di-O-caffeoylquinic acid (3), 3,5 di-O-caffeoylquinic acid (4), 3,4 di-O-caffeoylquinic acid (5) and 3,4,5-tri-O-caffeoylquinic acid (6) were identified by HPLC-UV-MS from the roots of Cephalaria gigantea (Dipsacaceae) growing in Georgia. The aim of the present research was a qualitative identification of phenolic constituents in an anticonvulsive enriched fraction from the roots of C. gigantea, for further quantitative standardization. The HPLC profile demonstrated a good resolution of phenolic acids of the active extract within 25 min of gradient mode (ACN 5% to 40%). On the basis of retention times, using the UV and MS spectra of the corresponding standards, compounds 4 and 5 were found to be majors in the analyzed fraction and were reported for the first time from C. gigantea roots. These experimental data could be a solid base for the future quantitative standardization of the anticonvulsive fraction for the prevention and treatment of psychosomatic forms of...
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Posted by admin on Apr 30, 2021 in |
The Plants having own biological potential to treat some major diseases. Medicinal plants are gaining much interest recently because their use in ethnomedicine treating common diseases such as cold, fever, and other medicinal claims are now supported with sound scientific evidence. The study on medicinal plants started with extraction procedures that play a critical role to the extraction outcomes (e.g., yield and phytochemicals content) and also to the consequent assays performed. A wide range of technologies with different methods of extraction is available nowadays. Hence, this review aims to describe and compare the most commonly used methods based on their principle, strength, and limitation to help to evaluate the suitability and economic feasibility of the...
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Posted by admin on Apr 30, 2020 in |
A novel coronavirus illness (COVID-19), activated by contamination with SARS-CoV-2, has frilled across 31 territories in China and more than 195 nations around the world. The change from the first side effects to intense respiratory trouble disorder (ARDS) is amazingly likely to be because of excessive cytokine discharge. There is a pivotal need to arrange sheltered and dynamic medications for activity. Chloroquine (CQ) presentations an inhibitory impact. In any case, the clinical utilization of CQ can cause serious reactions. Besides, hydroxyl chloroquine (HCQ) likewise shows an antiviral impact profoundly like that of CQ, restraining the cytokine storm by smothering T-cell enactment. Coronavirus immunization will be conveying after clinical preliminaries ahead in business...
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