Posted by admin on Oct 31, 2024 in |
Antioxidants are crucial in combating oxidative stress and related diseases. This study aimed to assess the antioxidant potential of methanolic root extract of Annona glabra Linn. and ascorbic acid is used as a reference. The plant material was subjected to sequential extraction using a solvent of varying polarities, utilizing a Soxhlet extraction method. The extract was tested for phytochemicals (secondary metabolites), total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity. The phytochemicals examination of root extract of Annona glabra Linn. exposed the presence of alkaloids, glycosides, flavonoids, saponins, phenols, steroids, terpenoids. TPC, TFC of crude methanolic root extract of plant was determined using Folin-Ciocalteus reagent and Aluminum chloride colorimetric method respectively. Antioxidant activities were determined spectrophotometrically using the DPPH assay, nitric oxide scavenging assay, hydrogen peroxide scavenging assay, phosphomolybdate assay, ferric reducing antioxidant power assay. The result of methanolic root extract shows the good antioxidant...
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Posted by admin on Oct 31, 2024 in |
In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including Bulk density, Tapped density, Angle of repose, Carr’s index, Hauser’s ratio, weight variation, hardness, friability, in-vitro dispersion time, drug content water absorption ratio, wetting time, in-vitro drug release. The tablet prepared by the direct compression method had a weight variation in the range of 198mg to 204mg which is below ±6.5%, Hardness of 3.7kg/cm2 to 4.3kg/cm2 , Percentage friability of 0.56% to 0.61%, in-vitro dispersion time of 18 sec to 24 sec, Wetting time of 33 sec to 51 sec and in-vitro drug release of 45.04% to 97.63% within 15 min. Fast dissolving tablets of metoprolol tartrate have enhanced dissolution and will lead to improved bioavailability and more effective therapy. The release rate of drugs from fast dissolving tablets intensifies with a rise in the concentration of super disintegrants and the metoprolol tartrate...
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Posted by admin on Oct 31, 2024 in |
Kidney stones and renal calculi impact a substantial percentage of the population presently. Urinary stones, also known as calculi, are a very old condition for which numerous treatments have been used over the years. It can be discovered in various areas of the urinary tract, including the kidney, ureters, and bladder with varied size. Frequently caused by calcium oxalate crystals, high uric acid levels, and insufficient citrate levels in the body. This recurrent condition and have reported a 50% lifetime chance of recurrence. The usage of synthetic pharmaceuticals has led to an increased risk of bad drug reactions, which has prompted many to look to nature for safe solutions. Patients are advised to follow a low-fat diet and consume fiber from naturally occurring plants as well as herbal remedies. The current article highlights that herbal medicine, superior to allopathic therapy when it comes to treating kidney and urinary stone...
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Posted by admin on Oct 31, 2024 in |
Aloe vera Linn. (Ghritokumari locally) has recently gained popularity due to its health benefits. The current ethnopharmacological review was carried out to assess the medicinal effects of A. vera using scientific data. It belongs to the Liliaceae family and is a perennial plant with 30-60cm long juicy leaves that grow across Bangladesh. Too far, more than 75 active compounds have been found in the inner gel of leaves, including aloes in, aloe emodin, acemannan, aloeride, methylchromones, flavonoids, saponin, amino acids, vitamins, and minerals. It contains anti-inflammatory, antioxidant, antibacterial, anticancer, anti-diabetic, immune-boosting, and hypoglycemic effects. This is beneficial as a daily supplement against stroke, heart attacks, leukemia, anemia, hypertension, AIDS, radiation burns, digestive issues, and other conditions. This research also discusses its taxonomy, distribution, morphology, and...
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Posted by admin on Oct 31, 2024 in |
The purpose of this work was to develop a novel topical formulation of econazole nitrate based on gel that can be easily scaled up in one pot for the potential treatment of fungal and yeast infections. Econazole nitrate is a topical antifungal, used to treat tinea versicolor, tinea pedis, and tinea cruris. Compared to applying cream or ointment, topical gels offer numerous advantages, one of which is that the drug is released more quickly to the intended site of action. A viscous mixture of propylene glycol, Triethanolamine, methyl paraben, and econazole nitrate were mixed together before being formulated into the optimized gel bases. The gel’s color, appearance, and homogeneity were assessed visually. For every formulation, the drug content, pH, viscosity, spreadability, and gel strength were characterized. The manufactured formulations were transparent, half white, pale yellow, and exhibited excellent homogeneity. The pH and viscosity are within the limit. The drug diffusion of F1 93.81, F2 97.56, F3 92.36, F4 90.95, F5 93.18 and F6 90.14. From among all the developed...
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