Posted by admin on Nov 30, 2025 in |
Inflammation is an essential component of the innate immune response and serves as a protective mechanism against harmful stimuli such as physical injury, infectious agents, toxic chemicals, and allergens. Although beneficial in acute phases, uncontrolled or chronic inflammation is associated with the development of numerous diseases, including rheumatoid arthritis, cardiovascular disorders, obesity, and cancer. During inflammatory responses, mediators such as interleukins, interferons, and tumor necrosis factor-α (TNF-α) are released, producing the characteristic signs of redness, pain, heat, swelling, and loss of function. Natural products have long played a significant role in managing inflammatory conditions, even with the availability of synthetic agents such as NSAIDs. Many medicinal plants contain bioactive secondary metabolites capable of modulating key steps in the inflammatory cascade by targeting pathways including COX, LOX, NF-κB, and oxidative stress. Numerous studies continue to highlight the anti-inflammatory potential of plant extracts, essential oils, and isolated phytochemicals. This review compiles recent findings on these natural agents, emphasizing their mechanisms of action and relevance in inflammation-associated metabolic disorders. It also provides...
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Posted by admin on Nov 30, 2025 in |
Coccinia grandis (L.) Voigt, commonly known as Ivy gourd, little gourd, or ‘Kundru’ in vernacular Indian languages, is a tropical perennial vine belonging to the Cucurbitaceae family. It is widely distributed across India, tropical Africa, Australia, and other Oriental countries, and has a long history of use in traditional medicine systems, such as Ayurveda and Unani. This review provides a comprehensive overview of the anti-inflammatory potential of C. grandis, encompassing its history, botanical characteristics, phytochemistry, and pharmacological profile. The plant is a rich source of essential nutrients, including protein, calcium, fiber, and beta-carotene (a precursor of vitamin A). It contains a diverse array of secondary metabolites, such as alkaloids, flavonoids, saponins, sterols, and triterpenoids (cucurbitacins B and D). The various parts of the plant (leaves, stems, fruits, and roots) have been used as a household remedy for a range of ailments, including skin eruptions, fevers, ulcers, and inflammation. Numerous scientific studies have validated these traditional claims, demonstrating significant anti-inflammatory, analgesic, anti-pyretic, and antioxidant activities through in-vitro and in-vivo models....
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Posted by admin on Nov 30, 2025 in |
Obesity is a globally concerning healthcare problem, leading to various chronic disorders. All over the world, over 4 million deaths are attributed to being overweight or obese. The study emphasises the rising prevalence of lifestyle disorders, particularly obesity. It advocates for holistic approaches that incorporate dietary modification, detoxification, and psychological support alongside traditional Ayurvedic practices. The Ayurvedic system is built on a rich pharmacopoeia that includes medicinal plants. Each plant has specific properties that contribute to the overall effectiveness of the formulation. The review highlights those medicinal plants used in Ayurveda for treating obesity and lipid disorders, detailing specific formulations such as Navak Guggul and Arogyavardhini Vati, TriphalaKwath and other herbal formulations, which are noted for their effectiveness in reducing overall lipid levels, including serum cholesterol and triglycerides. These are well-documented for their roles in managing lipid levels and promoting metabolic health. The finding underscores the significance of herbal treatment in managing dyslipidaemia and obesity, providing valuable insights for consumers and healthcare providers in making informed choices regarding herbal...
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Posted by admin on Oct 31, 2025 in |
Reproductive health and fertility can be shaped by a delicate balance of hormones, body functions, environment influences and lifestyle modifications. In recent years there’s been growing interest in role of nutraceuticals as these nutraceuticals consists of important vitamins, minerals, and antioxidants, nutritional foods that are crucial for improving reproductive health. Avocados, nuts, seeds, whole grains, green vegetables, fruits, and legumes are nutrient-rich foods that are known to promote hormonal balance, enhance the quality of eggs and sperm, and inhibit oxidative stress in reproductive organs. Particularly critical nutrients for enhancing ovulation, endometrial health, and sperm motility are folate, zinc, Tocopherols, iron, and omega-3 fatty acids. Additionally, diets high in antioxidants protects gametes from damage caused by free radicals, augmenting the probability of conception. A balanced lifestyle and adequate consumption of these fertility-promoting foods can help control infertility and greatly enhance reproductive results. Nutritious diets are therefore a safe, all-natural, and successful therapeutic strategy for treating...
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Posted by admin on Oct 31, 2025 in |
Prodrugs are bio-reversible, inactive drug by products that can convert into a parent drug inside the body. Around 10% of the medications accepted globally can be categorized as prodrugs. Prodrugs are designed to enhance the site-selective delivery of an active drug by modifying the physicochemical and pharmacokinetic properties of pharmacologically potent compounds. Prodrugs are changed and form active drugs inside the body through enzymatic or non-enzymatic reactions. This article describes the potent secondary metabolites from natural sources that are amenable to prodrug design. A fair number of them have issues of bioavailability and metabolism, resulting in less efficacy, and a prodrug strategy is required to improve their efficacy. This has come into the spotlight recently by achieving encouraging results in most cases. Many phytochemicals are not preferred due to their low solubility, decreased bioavailability, and adverse effects, but these problems can be overcome with the formation of prodrugs of such compounds. Several techniques can be used to synthesize these prodrugs, including biotransformation, electrophilic substitution, esterification, biomodulation, covalent conjugation, and...
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