Posted by admin on Jun 30, 2025 in |
Hyperlipidemia is a significant contributor to the global burden of cardiovascular diseases, such as coronary heart disease and stroke. Characterized by elevated plasma lipids, including cholesterol, triglycerides, and lipoproteins, hyperlipidemia is a prevalent health issue with increasing incidence in both developed and developing countries. According to the World Health Organization (WHO), raised cholesterol levels are linked to 4.5% of global deaths and account for 29.7 million disability-adjusted life years (DALYs) annually. The Fredrickson classification system, endorsed by WHO, categorizes hyperlipidemia into six types based on lipoprotein abnormalities, providing a foundation for understanding its diverse etiologies and clinical implications. Experimental induction of hyperlipidemia is pivotal for studying its pathophysiology and testing potential therapeutic interventions. Various screening methods have been developed, including the use of pharmacological agents, dietary modifications, and genetic models. This review discusses the epidemiology, classification, and methodologies used to induce hyperlipidemia in experimental settings, highlighting their relevance in advancing our understanding and management of this critical public health...
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Posted by admin on Jun 30, 2025 in |
Catharanthus roseus, population known as Vinca rosea, is a significant medicinal plant from the Apocynaceae family, used to treat various life-threatening diseases. It is known by names such as bright eyes, cape periwinkle, pink periwinkle, and Madagascar periwinkle. The plant contains chemical compounds like carbohydrates, flavonoids, saponins, and alkaloids, including vinblastine, vincristine, vindoline, monoterpenes, sesquiterpenes, indole, and indoline glycosides. Catharanthus roseus is native to the Indian Ocean Island of Madagascar and was once considered an endangered species in the wild. However, it is now found in many tropical and subtropical regions worldwide, including the southern United States. The plant demonstrates various pharmacological activities, such as anticancer, antidiabetic, antimicrobial, antioxidant, memory enhancement, wound healing, hypotensive, antidiarrheal, antiulcer, and hypolipidemic effects. In this review article express taxonomy, synonym, vernacular names, distribution, ethnomedical uses, phytochemicals and pharmacological activities of Catharanthus...
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Posted by admin on Jun 30, 2025 in |
Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately, these drugs cause increased risk of blood clot resulting in heart at tacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. Due to these side-effects, there is need for the search of newer drugs with less or no side-effects. There are hundreds of phytoconstituents reported to have many pharmacological activities although most of these reports are of academic interest and very few find entry in clinical trials. The present review is...
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Posted by admin on Jun 30, 2025 in |
Litchi (Litchi chinensis Sonn.) is a widely cultivated tropical fruit, enjoyed globally for its delicious taste, vibrant color, and high nutritional value. Beyond its culinary appeal, litchi has been used in traditional Chinese medicine for centuries to treat various ailments, including stomach ulcers, diabetes, and digestive issues. Herbal medicines have played a vital role in traditional healing practices, such as Ayurveda and homeopathy, offering effective treatments and cures for a range of diseases and physiological conditions. Recent studies have unveiled the fruit’s impressive range of health benefits, including antioxidant, anti-inflammatory, and anti-cancer properties, attributed to its rich composition of polysaccharides and polyphenols. However, consumption of litchi can also lead to adverse reactions in some individuals, likely due to its soluble protein content. This review aims to provide an overview of litchi’s nutrient profile, health benefits, and safety considerations, highlighting its potential applications in the food, medical, and cosmetics...
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Posted by admin on Jun 30, 2025 in |
Magnolia champaca, also known as Michelia champaca, is a member of the Magnoliaceae family, widely distributed across the sub-Himalayan region, West Bengal, Myanmar, South India, and apart from China. This plant is celebrated for its perfumery applications, earning the nickname “Joy Perfume Tree,” with its fragrance featured in the world’s second best-selling perfume, “Joy.” The plant boasts a diverse array of phytochemicals, including alkaloids, tannins, sterols, flavonoids, phenols, and saponins, suggesting its potential as a rich source of medicinal compounds. Michelia champaca has demonstrated a broad spectrum of pharmacological activities, including anti-microbial, anti-pyretic, anti-inflammatory, antioxidant, insecticidal, anti-uretic, carminative, and anti-diabetic properties. In this review article express taxonomy, synonyms, vernacular names, distribution, ethnomedical uses, phytochemicals, and pharmacological activities of Magnolia champaca have been...
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