Posted by admin on Jul 31, 2019 in |
Ocimum tenuiflorum Linn. commonly known as holy basil, tulsi is an aromatic perennial plant in the family Lamiaceae. It is native to the Indian subcontinent and cultivated plant throughout the Southeast Asian tropics, where the leaves, seeds ad stem of tulsi are used for valuable source of culinary and traditional medicinal uses. Indian material medica describes the use of the plants in a variety of ailments such as immunostimulatory effect, gastric antiulcer activity, diabetics mellitus, hyperlipidemia, wound healing effects, protective effect, chemopreventive activity, and blood pressure, etc. The present review aims to summarize up to date information on the ethnomedicinal, phytochemical and pharmacological activity. Until now, highly complex natural molecules have identified including fixed oils, essential oils, triterpenes, flavonoids, flavonoid glycosides, polysaccharides, phenolic glycoside, lignans, and norlignans. In addition to solvent extracts, these individual active compounds have been suggested for ethano-pharmacological activities. Although the results are promising in-vitro and in-vivo preclinical studies, clinical studies are insufficient; therefore, further investigation of each active compound need to be done to validate...
Read More
Posted by admin on May 31, 2019 in |
The role of surfactants is very critical in the development of pharmaceutical formulations. The diverse applications in different delivery systems have been highlighted in different reports of formulation development for various conventional and advanced delivery systems. The relevancy of critical micelle concentration and HLB value for the section of surfactants for different drug delivery systems was rationalized with suitable examples. The present attempt is focused on the compilation of all the important aspects of surfactants with a broad discussion on the drug delivery implications. The regulatory status of different investigational surfactants has been criticized relevantly with a compilation of FDA approved surfactants. The safety aspects of newly developed surfactants must be ensured before their incorporation in therapeutic dosage forms. The properties of different categories of surfactants were discussed with special emphasis on their physicochemical properties. The compiled information will make a firm base for the selection of surfactants for conventional and advanced drug delivery systems. Precise information on surfactant toxicity was also included to give a check to the...
Read More
Posted by admin on May 31, 2019 in |
The liver is an amazingly complex organ which virtually affects every physiological process of the body. The liver is the largest glandular organ in the body and has more function than any other organs. Hepatic disorders which stem from a stressful lifestyle, inappropriate eating habits, and lack of exercise have become one of the major causes of morbidity and mortality in human being. The acute hepatic symptoms may be cured by some general prevention such as avoidance of constipation and balance between intake quantity of protein and disaccharides in normal food. An alternative and progressively increasing adaptation is the use of herbal extracts. Many of the plant-based drugs show an effective response to managing the hepatotoxicity and secondary symptoms of liver damage. While, the models used for conventional hepatotoxicity evaluation are still outdated, in the present review we have attempted to provide updated information of the molecular pathogenesis and aspects for the role of herbal pharmacotherapy in the alleviation of hepatic ailments. Furthermore, we have attempted to summarize the...
Read More
Posted by admin on Apr 30, 2019 in |
Diabetes mellitus is a metabolic disorder in which blood glucose level decrease. Due to this disease, various complications are arises including retinopathy, nephropathy, cardiovascular disease, and neuropathy. Diabetes mellitus is a chronic condition includes Type 1 DM, Type 2 DM and gestatational diabetes, which occurs in pregnancy. For the management of DM various system of medicine is used, from that herbal or traditional medicine is used for many cases as a core medicine or supplementary to allopathic medicine. Frequency of occurrence of type 2 DM is high than type 1 DM. Different type of plant or herbal extract are used for management of DM includes, Ocimum sanctum, Allium stivum, Eugenia jambolana, Abelmoschus esculentus, Allium cepa, Gymnema sylvestre, Momordica charantia, Pterocarpus marsupium etc. Many plants are use as single herb extract for treatment or used in combination with other anti-diabetic plants as a poly herbal...
Read More
Posted by admin on Apr 30, 2019 in |
Molecular Beacons (MBs) are DNA hairpins that are widely used as fluorescent probes. The inherent signal transduction mechanism let them differentiate between target and non-target oligonucleotides that differ even on a single base. The stem-loop structure consists of donor and acceptor moieties conjugated to both ends thus lying nearby, which leads to FRET. On hybridization to target sequences that hairpin opens up, restoring fluorescence. MBs technology can be applied to a wide range of fields from genetic screening, biochip development, biosensor construction and even mRNA expression in living cells. Recent developments consist of modifications to improve not only the stability of MB in living cells but also lowering signal to noise...
Read More