Posted by admin on Aug 31, 2024 in |
Plants serve human as a primary source of food, shelter, and medicine. So, understanding the plants uses in treating diseases is very important for leading a healthier life. Helminthes infection are usually found in community and are well recognized as cause of much acute and chronic illness among the individual as well as cattle’s. For evaluating that we select the Pherithema posthuma a Helminthes is frequently known as earth-worms. For that we evaluated the anthelmintic activity of aqueous and methanolic extracts of leaves of Euphorbia hirta linn. (euphorbiaceae) using different concentration of above solvent extract we evaluated the Time of paralysis (P) and Time of death (D) of the worms. The main active constituent responsible for showing the anthelmintic efficacy in the Euphorbia hirta plant is believed that Quercetin, a flavonoid. This plant contains several bioactive compounds, butquercetin has been widely studied for its broad-spectrum biological activities including anthelmintic activity. Albendazole (Std) was used as standard. Anthelmintic drug and Dis. H2O was used as a control. The result of...
Read More
Posted by admin on Aug 31, 2024 in |
Despite its succulent fruit, Cucumis melo L. is a widely grown crop in many parts of the world. Developing consumer-favored cultivars requires an understanding of the genetic foundation of a plant’s qualitative and quantitative features. Cucumis melo L. is a delightful oval-shaped fruit that belongs to a particular cultivar group of muskmelons. It is the most exported and consumed fresh fruit and is consumed widely in many tropical nations. It has incredible nutritional value. It was evaluated how different organic solvents affected the phytochemical recovery from the fruits and seeds of the Cucumis melo L. plant. Its widespread cultivation is attributable to its adaptability to many soil types and climates. Because of its complex chemical makeup and pleasant taste, melons are a great source of biologically beneficial chemicals for humans. Melon contains glucose, fructose, vitamin A, thiamine, D, C, K, and E, as well as a few vitamins from group B. Aqueous or fresh extracts of the edible portion of melon fruit have long been employed as analgesics, purgatives,...
Read More
Posted by admin on Jul 31, 2024 in |
The newest approach in pharmaceutical production linked to quality is called Quality by Design (QbD). To guarantee that premium-grade pharmaceuticals are produced, Pharmaceutical Quality by Design, or QbD, is discussed in this article. A description of Quality by Design is provided along with a list of its constituent parts. Every unit activity has its own set of quality metrics and characteristics. The use of Quality by Design and its associated measures can yield significant benefits for pharmaceutical goods. The foundation of pharmaceutical R&D is high-quality drugs and the procedures used in their production. A product’s quality cannot be easily verified because this paper just summarises the product’s quality profile and the most important components of Quality by Design. Quality by design (QbD) and end-product testing are two ways to compare the quality of various goods. Quality by Design is based on the ICH Guidelines. ICH guidelines apply to the development of medications and the application of quality control methods. The research and manufacturing of pharmaceuticals might profit from Quality...
Read More
Posted by admin on Jul 31, 2024 in |
The computer-aided drug design (CADD) symbolizes an intricate discipline exploitation accomplishment in varied areas of science and varied strategies and approaches. It tends to speed-up and optimize discovery of latest biologically active compounds. However, these approaches cannot replace the experimental tests. The aim of CADD is to generate hypotheses regarding probable new ligands and their interaction with targets. It’s considered that these strategies will decrease the quantity of the compounds that are required to be synthesized and tested for biological activity up to 2 orders. Thus, they’re capable to decrease basically time consuming monetary expenses for development of medicine. A Recent terribly effective technique in era is drug designing through computers. CADD technologies are employed in technology, biological science, organic chemistry etc. The main advantage of the CADD is value effective in analysis and development of medicine. There are wide ranges of software that are employed in CADD, Grid computing, window primarily based general PBPK/PD modeling computer software, PKUDDS for structure based drug design, APIS, JAVA, Perl and Python....
Read More
Posted by admin on Jul 31, 2024 in |
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. The solubility of a medication determines its bioavailability. As new medications are developed, solubility becomes a significant concern for the pharmaceutical industries. About 40% of recently developed medications fit into the poor water soluble or water insoluble classifications. Generally speaking, weakly water-soluble medications have an aqueous solubility of less than 100μg/ml. There are numerous ways to improve the solubility of poorly soluble medications, and one particularly effective method is the use of liquisolid compacts. A unique idea for a novel drug delivery system (NDDS) that can speed up the rate at which water-insoluble medications dissolve is the liquisolid compact system. The basis of this liquisolid method is the dissolution of the insoluble drug in a non-volatile solvent, followed by the mixing of drug-loaded solutions with suitable carriers and coating materials to produce powders that flow and compress into acceptable levels. These free-flowing powders are compressed to make tablets or filled in...
Read More
