A REVIEW ON LIQUISOLID TECHNOLOGY TO ENHANCE DRUG DISSOLUTION
AbstractDissolution of drug and its release from the dosage form have basic impact on bioavailability. The solubility of a medication determines its bioavailability. As new medications are developed, solubility becomes a significant concern for the pharmaceutical industries. About 40% of recently developed medications fit into the poor water soluble or water insoluble classifications. Generally speaking, weakly water-soluble medications have an aqueous solubility of less than 100μg/ml. There are numerous ways to improve the solubility of poorly soluble medications, and one particularly effective method is the use of liquisolid compacts. A unique idea for a novel drug delivery system (NDDS) that can speed up the rate at which water-insoluble medications dissolve is the liquisolid compact system. The basis of this liquisolid method is the dissolution of the insoluble drug in a non-volatile solvent, followed by the mixing of drug-loaded solutions with suitable carriers and coating materials to produce powders that flow and compress into acceptable levels. These free-flowing powders are compressed to make tablets or filled in capsules.
Article Information
3
406-413
897 KB
56
English
IJP
Rama Brahma Reddy *, K. Malleswari, H. G. Diwakar, D. Kadhar Basha and K. John Abhi
Nalanda Institute of Pharmaceutical Sciences, Siddharth Nagar, Kantepudi, Sattenapalli, Guntur, Andhra Pradesh, India.
malleswarikunchala105@gmail.com
15 July 2024
23 August 2024
28 August 2024
10.13040/IJPSR.0975-8232.IJP.11(8).406-13
31 August 2024
Download