Posted by admin on Jul 31, 2024 in |
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. The solubility of a medication determines its bioavailability. As new medications are developed, solubility becomes a significant concern for the pharmaceutical industries. About 40% of recently developed medications fit into the poor water soluble or water insoluble classifications. Generally speaking, weakly water-soluble medications have an aqueous solubility of less than 100μg/ml. There are numerous ways to improve the solubility of poorly soluble medications, and one particularly effective method is the use of liquisolid compacts. A unique idea for a novel drug delivery system (NDDS) that can speed up the rate at which water-insoluble medications dissolve is the liquisolid compact system. The basis of this liquisolid method is the dissolution of the insoluble drug in a non-volatile solvent, followed by the mixing of drug-loaded solutions with suitable carriers and coating materials to produce powders that flow and compress into acceptable levels. These free-flowing powders are compressed to make tablets or filled in...
Read More
Posted by admin on Jul 31, 2024 in |
Cancer is a disease of cells where uncontrolled proliferation occurs leading to death of the incumbent. There is no effective vaccine for prevention and prophylaxis of cancer. Currently available anticancer allopathic drugs have a lot of disadvantages including frequent recurrence of the disease. In this perspective, nature could be a good alternative source of anticancer herbs and phytoconstituents that may prevent the proliferation of cells and even cure the cancer. This review summaries such herbs and phytoconstituents that could give good preventive and prophylactic effect as anticancer...
Read More
Posted by admin on Jul 31, 2024 in |
Common kinds of chemotherapy may cause harm to normal cells and tissues. Localised chemotherapy, unlike systemic chemotherapy, can lessen side effects by providing a consistent supply of chemotherapeutic chemicals directly to the tumour location. This emphasises the importance of controlled-release biodegradable hydrogels as chemotherapeutic drug delivery systems. This study looks at employing hydrogels as drug delivery methods for HCC, including thermosensitive, pH-sensitive, photosensitive, dual-sensitive, and glutathione-responsive hydrogels. Hydrogel-based drug delivery systems outperform traditional systemic chemotherapy in cancer treatment. Cancer immunotherapy has emerged as the new paradigm for cancer treatment. The development and discovery of new therapeutic molecules has increased the use of immunotherapy in clinical studies. This article discusses the current state of functional hydrogels for effective cancer immunotherapy. First, we will discuss the fundamental principles of cancer immunotherapy and the benefits of employing hydrogels to implement these mechanisms. Finally, we briefly explore the existing issues and potential applications of hydrogels for effective cancer...
Read More
Posted by admin on Jul 31, 2024 in |
Background: Prosopis cineraria is regarded as a significant herbal plant because of its many therapeutic properties. It is a member of the global tribe Leguminosae, subfamily Mimosaceae, and genus Prosopis. Prosopis species, which are indigenous to Africa, the Americas, & Asia, have long been used in traditional medicine. The Prosopis species that are used for medicinal reasons most frequently are Prosopis africana, Prosopis alba, Prosopis cineraria, Prosopis farcta, Prosopis glandulosa, Prosopis juliflora, Prosopis nigra, Prosopis ruscifolia, and P. spicigera. Method: The economically significant Prosopis tree component is its wood, which is used to make charcoal, firewood, and fuel. It is becoming evident that biological effects are related to the Prosopis plants’ phytochemical makeup, particularly the presence of C-glycosyl flavones in these species (such as isoschaftoside, vicenin II, and isovitexin) Prosopis plants are consequently advantageous for human diet and overall health, claims study. In such a way, this current study offers a thorough summary of the research on the chemical make-up, pharmacology, and food uses of Prosopis plants, ranging from pre-clinical information to upcoming clinical investigations. Conclusion: Medical...
Read More
Posted by admin on Jun 30, 2024 in |
Since ancient times, Baccaurea species have held economic value for the indigenous peoples of the Old-World Tropics, used for both their edible fruits and medicinal properties. Among these, Baccaurea motleyana, commonly known as Rambai, is notable for its diverse uses and is widely cultivated across Southeast Asia. This study explores the botanical characteristics, traditional applications, and pharmacological potential of B. motleyana. Rambai thrives in tropical rainforests and diverse soil types, growing up to 25 meters tall. The fruit is consumed fresh, while various plant parts are used medicinally to treat ailments such as constipation, eye swelling, arthritis, and abdominal pain. Notably, the bark is used to prevent postpartum hemorrhage, and the leaves treat menstrual disorders. Nutritionally, Rambai fruits are rich in vitamins and minerals, including vitamin C and potassium, and exhibit antioxidant and antimicrobial properties due to their high phenolic content. Phytochemical screening reveals the presence of alkaloids, flavonoids, saponins, triterpenoids, and tannins, contributing to its medicinal properties. Pharmacological studies highlight its antioxidant, antimicrobial, antidiabetic, and anticancer activities. For...
Read More
