Posted by admin on Aug 1, 2014 in |
Spirulina platensis is a blue-green alga that widely used as a food supplement over worldwide. Two models were used to study the effects of Spirulina platensis on nociception which was induced by acetic acid (Writhing test), formalin (Paw licking test). Spirulina platensis was administered in the dose range of 200 and 400 mg/kg orally 1 h before pain induction. Spirulina platensis contains β-carotene and biliproteins (phycocyanin and biliphycocyanin). Oral administration of Spirulina platensis revealed dose-dependent antinociceptive effect in all the models for antinociception, and it blocked both the neurogenic and inflammatory pain, and the nociceptive activity was comparable with the reference drug. The results indicate that 400 mg/kg dose of Spirulina platensis showed significant antinociceptive activity. The activity can be related with the significant biliprotein such as phycocyanin and biliphycocyanin that have potent antioxidant...
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Posted by admin on Aug 1, 2014 in |
In the present study we screened four medicinal plants for the α-amylase inhibitory activity of each extracts phytochemicals, and it was determined based on the colorimetric assay using acarbose as a reference compound. The aqueous and ethanol extracts of the medicinal plants viz. Enicostemma littorale, Achyranthes aspera, Abutilon indicium, and Tridax procumbens were shown moderate α-amylase inhibitory activity against a reference, an account of that Achyranthes aspera shows potent activity towards remaining. Not only leaves but also the whole plant is used for comparative in-vitro study of inhibition of α- amylase...
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Posted by admin on Aug 1, 2014 in |
The quality control assessment of herbal formulations is of great significance to justify their acceptability in the modern system of medicine though the drug may be therapeutically potent. Ayurvedic formulations prepared by several manufacturers are guaranteed to carry out the quality control test as per the standards mentioned in the Ayurvedic Formulary of India. Though the standards have been followed, still the variability in their results has been observed when compared between the same formulations. Vyoshadivati is one such polyherbal formulation consisted of 13 drugs and treated for ailments viz. Pinasa (coryza), Pratishaya (Rhinitis), Swarabheda (Hoarseness of voice), etc. An attempt is made here to compare Vyoshadivati prepared by GMP certified pharmacies with In house preparation. Results revealed that all the samples differ in their organoleptic, pH, and physicochemical properties. Thin Layer Chromato-graphic study showed sample B, D and E have an almost similar number of bands at the wavelength of 255 nm and 365 nm. Major difference was seen in disintegration time and hardness of sample A, i.e....
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Posted by admin on Aug 1, 2014 in |
Nanosuspensions have the versatile potential for efficient exploitation of different drug delivery formulations and routes because of the properties provided by their small size. In the present study, curcumin extraction was carried out from Curcuma longa (crude curcuminoids) using soxhlet extraction method with ethanol as a solvent which gives a high yield. Formulations of nanosuspensions with the nanoprecipitation technique are made using polycaprolactone (PCL) as a polymer, with extracted natural curcumin, and with synthetic curcumin. A comparison is made for parameters such as product yield, drug content, drug entrapment efficiency and in-vitro studies between the formulation of nanosuspensions with naturally extracted curcumin and synthetic curcumin. Average particle size obtained ranging from 297.4 nm to 973.1 nm for different formulations with natural curcumin and 253.8 nm to 850.1 nm for different formulations with synthetic curcumin. Entrapment efficiency of nanosuspension ranged between 66.7% to 80.78% for natural curcumin and 68.78% to 80.86% for synthetic curcumin. Drug content ranged from 67.41% to 85.70% for formulation with natural drug and 68.27% to 83.27%...
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Posted by admin on Aug 1, 2014 in |
Qualitative phytochemical screening of C. sativa leaf, stem and root was studied. Four solvents viz; n-hexane, chloroform, alcohol and aqueous revealed the variation in phytochemicals presence and absence in all studied parts. Extracts of different solvents were subjected to qualitative phytochemical screening using a standard protocol. Results showed the maximum number of phytochemicals present in leaf followed by stem and root. They are as follows; steroids, fixed oil, resins, alkaloids, terpenoids, flavonoids, tannin, proteins, and amino acid, phenolics, glycosides, saponins. Variation in a number of phytochemicals also observed in different solvents...
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