Posted by admin on Jul 26, 2014 in |
The present study was aimed to investigate the possible antidiarrheal, antidiabetic, antioxidant and antimicrobial activity of methanolic extracts of leaves of Clerodendrum viscosum (Vent.) Different screening models are employed for an investigation like Castor oil induced diarrheal model for antidiarrheal activity screening, alloxan-induced diabetic model for antidiabetic activity screening, antioxidant activity by DPPH scavenging method and disc diffusion method for the antimicrobial activity screening. Clerodendrum viscosum (Vent.) shows good anti-diabetic, antidiarrheal and antioxidant activity but having no antimicrobial activity in relationship with the standard drug. Clerodendrum viscosum (Vent.) methanolic extract dose of 500mg/kg significantly reduces the blood glucose level at a 1st hour to 3rd hour 130 to 36 mg/dL in in–vivo mice model. During antidiarrheal screening, Clerodendrum viscosum (Vent.) extract dose reduces the number of stool from 3 to 1in 1st hour to 3rd of treatment. DPPH scavenging activity on Clerodendrum viscosum (Vent.) was significant with the standard. IC50% 8.93 µg/mL and 7.8 µg/mL for sample Clerodendrum viscosum (Vent.) and standard ascorbic acid...
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Posted by admin on Jul 26, 2014 in |
Antiseptics and Disinfectants are extensively used in the health care industry and also equally in personal hygiene. Among the chemicals, silver has long been known to have antimicrobial activity. Development of new, effective and low-cost antimicrobial textiles has been an objective of this research work due to increasing resistance of microbial pathogens to traditional chemicals. The potential effectiveness of silver socks (SS) fabric as an antimicrobial agent was evaluated in this study. Silver nitrate (10-3M) coated cotton socks significantly reduced the bacterial load of the socks flora among the medical students. The bacterial load is directly proportional to many days and inversely proportional to the concentration of silver nitrate. Pseudomonas species was isolated from four samples in day 3. This study reported that 10-3M silver nitrate solution coated cotton socks were very effective and having bacterial isolates...
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Posted by admin on Jul 26, 2014 in |
Purpose: Dichlorvos (DDVP) causes toxicity in animals including humans. Alstonia boonei stem bark is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties. This study was designed to evaluate the effect of Alstonia boonei (AB) against dichlorvos induced nephrotoxicity in Wistar rats. Methods: Dichlorvos (50 mg/kg body weight) was orally administered in Wistar rats for 14 days followed by the treatment of Alstonia boonei (200 and 400 mg/kg body weight) for 14 days. Changes in the kidney biochemical marker namely, glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), aminotransferase (ALT), aspartate aminotransferase (AST) activities and levels of malondialdehyde (MDA), urea, and creatinine in the serum were estimated. Histological examinations of the kidney were monitored. Results: Exposure to dichlorvos lowered activities of kidney antioxidants, while it increased LPO levels. Levels of all disrupted parameters were alleviated by co-administration of AB extract. The malondialdehyde concentration of the rats treated with 200 and 400 mg/kg body weights of the extract significantly decreased (p<0.05) when...
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Posted by admin on Jul 1, 2014 in |
The ethanol leaves extract of Crotalaria pallida (Aiton) was evaluated to investigate the Phytochemical nature and some selected pharmacological activities. The plant extract indicated the presence of combined reducing sugar, tannins, flavonoids, glycosides, alkaloids and steroids. The extract showed free radical scavenging activity with an IC50 value of 37.60 µg/ml, and standard ascorbic acid showed IC50 value of 16.95µg/ml. The total phenolics content (TPC) was found to be 14 ± 0.015 mg GAE/g of dried plant extract. Total flavonoids content was found to be 20.42 ± 0.001 mg QE / 100 g of dry extract. The extract showed mild antibacterial activity against the bacterial strains Vibrio cholera, Shigella flexneri, Shigella dysenteriae, in comparison with standard drug kanamycin (30 µg/disc). In the anthelmintic test, the extract showed a dose-dependent decrease in paralysis time and death time of worm Paramphistomum cervi (trematoda) when compared with standard albendazole. These results espouse the traditional use of the leaves of this...
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Posted by admin on Jun 1, 2014 in |
The present study is part of the continuing programme related to the antihelminthic activity and phytochemical screening of Andrographis paniculata Nees. (Kalmegh) and their enhanced potential on helminths. The antihelminthic activity of the aqueous extract of Andrographis paniculata Nees. leaves against the adult Indian earthworms Pheretima posthuma due to its anatomical and physiological resemblance with the intestinal roundworm parasites of human beings. Several plant species are administered orally to control the various diseases in our country. Some of these plants have been pharmacologically provided to be of some value and maybe a popular remedy for the treatment of various ailments. The growth of knowledge to cure disease continues at an accelerating pace and number of new plant-derived drugs increase likewise. Herbal medicine is currently experiencing a revival in Western society along with other complementary therapies such as traditional Chinese Medicines, Osteopathy and Homeopathy. In this context, the present study is the first milestone with particular emphasis on the application of Andrographis paniculata Nees. (Kalmegh) the medicinal plant, their antihelminthic...
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