Posted by admin on Mar 13, 2016 in |
Sonchus arvensis, a perennial sowthistle, is a common but underutilized species of Kathmandu, Nepal. Several uses like sedative, antioxidant and kidney stone eradicating properties have been identified till date, but a study on other pharmacological activities is not yet explored. Therefore, the plant was collected from Kathmandu; aerial parts of the plant were dried, crushed, and extracted using a Soxhlet apparatus. The methanolic extract was then concentrated for screening pharmacological effects. While comparing with the standards, the plant was found to possess potent anti-inflammatory activity and inhibitory effect in Gastro-Intestinal (GI) motility and locomotor activity in a dose-dependent fashion. The plant, however, didn’t show skeletal muscle relaxant activity as observed in the traction test and inclined plane test. Thus, it is concluded that the plant possesses strong phytochemicals having anti-inflammatory activity and inhibitory effect in locomotion and GI...
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Posted by admin on Jan 30, 2016 in |
The global market for herbal products is exploding. The major hindrance in the amalgamation of herbal medicines into modern medical practices is the lack of scientific and clinical data and a better understanding of efficacy and safety of the herbal products. The evaluation or standardization of a crude drug involves Pharmacognostic methods such as organological, physicochemical, phytochemical and pharmacological analysis. The experimental material selected for the present study is Tragia plukenetii R. Smith belongs to the family Euphorbiaceae. This herb is distributed in hill slopes of southern peninsular India. The root is diaphoretic and alternative and is given for fevers to cause perspiration. The present paper deals with anatomical characters of leaf, stem, and roots. The dried powders of stem, leaves and roots and their extracts in various solvents were examined with ordinary light and U.V. light (365nm). Quantitative determination such as moisture content, total ash, water-soluble ash, acid insoluble ash, water extractive values, and sulfated ash have also been made. Preliminary phytochemical analysis of the extracts was done...
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Posted by admin on Jan 30, 2016 in |
The plant of Desmodium triflorum Linn (Fabaceae) is reported to have great medicinal value. The aim of this study to evaluate pharmacognostic evaluation including examination of morphological characters, ash value, powder analysis, and extractive values was carried out. Phytochemical screening including chemical examination and chromatographic study were also carried out. This would help to scientifically justify its pharmacological activities of particular chemical constituents in different...
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Posted by admin on Jan 30, 2016 in |
Aim of the present study is to analyze Mūcāmparap paṛṛu, a poly herbomineral Siddha formulation for physicochemical parameters, TLC photo documentation, and HPTLC fingerprint profile studies. The physicochemical parameters such as ash contents, solubility in water and ethanol, pH, loss on drying and successive extraction with hexane, chloroform, and ethanol were carried out. Hexane, chloroform, and ethanol extracts were subjected to TLC photo documentation, HPTLC analysis. HPTLC fingerprint profile under UV 254 nm, hexane extract showed 13 peaks, chloroform showed 9 peaks and ethanol showed 10 peaks; under UV 366 nm, hexane showed 11 peaks, chloroform showed 15 peaks and ethanol showed 12 peaks; after derivatization with vanillin-sulphuric acid all the extracts showed 11 peaks. The results obtained in the study are specific and could be used as a reference in the quality control of the...
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Posted by admin on Jan 30, 2016 in |
New series of N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl) 2-methyl-1H-indole-3-carboxamide derivatives (VIa-d) were prepared and tested for their antibacterial and antifungal activity. The synthesis is based on the condensation of phenylhydrazine and ethyl acetoacetate in the presence of acetic acid to ethyl (2-methyl-1H- indol-3-yl)-2-oxoacetate (III) which on reaction with hydrazine hydrate gives 2-(2-methyl-1H-indol-3-yl)-2-oxoacetohydrazide (IV). Further conden-sation of oxoacetohydrazide and substituted benzaldehyde gave carbohydrazide derivatives (Va-d). Finally addition of triethylamine in dry 1, 4-dioxane and chloroacetyl chloride gave N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl)2-methyl-1H-indole-3-carboxamide derivatives (VIa-d). The structure of newly synthesized 4-Oxoazetidin Substituted derivatives has been established by spectral (IR, 1HNMR) data. These compounds were screened for antibacterial and antifungal activity against various gram-positive and gram-negative strains. All the compounds show significant antibacterial and antifungal...
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