Posted by admin on Nov 13, 2017 in |
Natural products from plants are rich sources of chemical diversity and most of the pharmacologically active principles currently used as drugs, including anticancer agents are plant products. The present study aims at phytochemical screening and evaluation of the anticancer potential of methanolic extract of Garcinia indica fruit rinds belonging to Family Clusiaceae. The methanolic extract of dried Fruit rinds of Garcinia indica was subjected to the phytochemical tests to confirm the presence of Carbohydrate, alkaloids, steroids, Glycosides, flavonoids, Tannic acid and phenolic compounds, proteins, and fixed oils. In-vitro antioxidant activity of the extract was assayed using DPPH radical scavenging assay, hydrogen peroxide scavenging activity, reducing power activity. Total phenol and flavonoid contents were determined and expressed in gallic acid and catechin equivalent respectively. The results of the study indicate that the methanolic extracts of the Garcinia indica fruit rind possess significant scavenging activity against DPPH (78.1 μg/ml), reducing power activity (0.387 absorbances at 100 μg/ml) free radical scavenging activity (44.64 μg/ml). The free radical scavenging and promising antioxidant activities...
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Posted by admin on Oct 13, 2017 in |
Objective: To perform the phytochemical screening and anticonvulsant activity of methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm. Method: The physicochemical parameter and in-vitro anticonvulsant study were done. The anticonvulsant activity of methanolic extract of leaves of Cinnamomum tamala (100 and 400 mg/kg, p.o) in Wistar rats was assessed by using the Maximal Electric Shock test. Result: The present study shows different physicochemical analysis which reveals the presence of various metabolites. The methanolic extract of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm significantly reduced the duration of seizure induced by maximal electric shock. The methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm in doses of 100 and 400mg/kg conferred protection (39.65% and 45.97% respectively) on a rat. Conclusion: The methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm possess anticonvulsant activity since it reduced the duration of seizures produced by maximal electric...
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Posted by admin on Oct 13, 2017 in |
Diabetes mellitus is one of the widespread and severe metabolic disorders in humans all over the world. It is initially characterized by a loss of glucose homeostasis resulting from defects in insulin secretion, insulin action or both resulting in impaired glucose metabolism and other energy-yielding fuels such as lipids and proteins. The association of hyperglycemia with altered lipid parameters presents a major risk for all cardiovascular diseases. In recent years, there has been an increased inclination towards herbal drugs due to the trend towards the natural sources and healthy lifestyle. The present study was designed to evaluate the potential antihyperlipidemic efficacy of Citrullus colocynthis roots in streptozotocin (STZ) induced diabetic rats. Diabetes was induced by giving streptozotocin (35-50mg/kg) intraperitoneally. The aqueous and ethanolic root extracts of Citrullus colocynthis (AECC and EECC) were administered at a dose of 100, 200, 300 mg/kg orally. Metformin was given as a standard drug at a dose of 50mg/kg orally. The fasting and postprandial blood glucose levels were estimated by the glucose oxidase method....
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Posted by admin on Oct 13, 2017 in |
Green synthesis is a cheaper, clean, nontoxic route for the synthesis of large scale nanoparticles without the use of high energy, pressure, temperature, and toxic chemicals. With the help of microbial enzyme and plant extract nanoparticles are easily synthesized by utilizing their antioxidant and reducing properties. In the present study, biosynthesis of silver and gold nanoparticles by utilizing Alhagi maurorum stem aqueous extract reducing capabilities was successfully done. Nanoparticles synthesized were characterized with the help of UV – VIS spectroscopy, Transmission Electron Microscopy (TEM) and Fourier Transform Infra-Red spectroscopy (FTIR). UV – VIS spectroscopic analysis showed absorption maxima at 450 nm and 540 nm for silver (AgNP) and gold nanoparticles (AuNP) respectively. TEM study revealed that the silver and gold nanoparticles synthesized were in the range of 26-40 nm and possesses a crystalline structure having a nearly spherical shape. FTIR spectra of both AgNP and AuNP also confirmed the synthesis of nanoparticles and involvement of various reducing agent of plant extract. No change in the intensity of the AgNP...
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Posted by admin on Sep 8, 2017 in |
A simple TLC method has been developed for the simultaneous quantification of bergenin using HPTLC plate precoated with silica gel 60 F254. The method was developed in toluene: ethyl acetate: acetone (2:4:4 v/v) toluene: ethyl acetate: formic acid (4:6:1, v/v) and validated in terms of precision, repeatability, and accuracy. The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin. The in-vitro antioxidant activity of the isolated compound was determined. For the antioxidant potential, two standard analytical protocols, namely, DPPH radical scavenging activity (RSA) and ferric reducing antioxidant power were adopted. The results showed that the compound was found to be a more potent...
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