STUDY OF ANTHELMINTIC AND INSECTICIDAL ACTIVITY OF BACCAUREA RAMIFLORA PLANT IN DIFFERENT EXTRACTSAbstract
Baccaurea ramiflora Lour., syn. Baccaurea sapida (Roxb.) Muell. Arg. known as Burmese grapes belongs to the family Euphorbiaceae and is native to Southeast Asia. The observance on Baccaurea ramiflora leads that this plant is utilized as an antichloristic and anodyne against rheumatoid arthritis, abscesses, cellulitis and treat injuries. This plant also has anti-diarrheal, analgesic, anti-inflammatory, neuro-pharmacological, antioxidant and cytotoxic activities. Therefore, the present study was conducted to evaluate anthelmintic and insecticidal activities of different extract of Baccaurea ramiflora. For anthelmintic activity, Pheretima posthuma was selected as test animal while 25, 50, 100 mg/ml concentrations of samples were tested in the bioassay, from which time of paralysis and time of death of worms were estimated. Evaluation of insecticidal activity was performed against Sitophilus oryzae to calculate the mortality rate. Extracts of MEE, EE, ACE, CHE, PEE, and NHE were for the activity determination. In the anthelmintic study, extract exhibited its activity in a dose-dependent manner showing higher the concentration, faster the effect. Extract of EE, PEE, CHE and MEE in case of 100 mg/ml concentration exhibited its paralytic effect followed by death within a short period among which ACE extract gave the best result which only took approx. 22.33 min to show paralytic effect and 33 min for death occurrence. In the insecticidal activity, all extracts showed potent activity with 100% mortality of rice insects Sitophilus oryzae at 80 mg/ml concentration in 24 h, proving the activity also followed a dose-dependent pattern. 80% mortality rate observed in case of 80 mg/ml concentration of ACE extract in 12 h whereas MEE, CHE, and NHE extracts showed 60% and PEE showed 70% mortality rate in treated rice insects. The present study shows that all the extracts of Baccaurea ramiflora are found to possess anthelmintic and insecticidal activities.
K. N. Al-Masud *, Z. Morshed, M. N. Islam, M. Hossain, M. T. Deeba and R.Islam
Department of Pharmacy, BRAC University, Dhaka, Bangladesh.
10 July 2018
10 August 2018
19 August 2018
01 September 2018