Posted by admin on Mar 31, 2019 in |
Ajuga chamaepitys (L.) Schreb, well-known as Camaepitiumor Ground Pine, is an annual herb typical of the Mediterranean area accounting several uses in the traditional medicine. In this study, the methanol extract of Ajuga chamaepitys (L.) Schreb was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS), while the mass spectra of the compounds found in the extract were matched with the National Institute of Standards and Technology Library. The study revealed the presence of fifteen phytocomponents. The most abundant compounds in the methanol extract were eucalyptol, thujone, endoborneol, davana ether, and octacosane. The results indicated that polarity of the solvents used in extraction influenced the relative abundance and type of compounds extracted. The various compounds identified are known to have varying bioactivities such as being hemorrhoids, stomachache, jaundice, and inflammatory diseases....
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Posted by admin on Feb 28, 2019 in |
Malaria is a significant public health problem in the world, and the rising problem of drug resistance and the availability of a limited number of effective anti-malarial drugs underline how essential it is to find new anti-malarial agents. This study was undertaken to evaluate the in-vivo antimalarial activities of an extract of Hagenia abyssinica that is used traditionally to treat malaria in Ethiopia. The rodent malaria Plasmodium berghei was used to infect healthy 7-week-old Swiss albino mice weighing 24-28 gm. Each of the extracts (100 mg/kg, 200 mg/kg, and 400 mg/kg) was administered to different groups of mice. The parameters of parasitemia, survival time, body weight, and packed cell volume were measured using repository test and Peter’s test. The extract significantly inhibited parasitemia and increased survival time in infected mice in a dose-dependent manner. The extract prevented loss of weight, packed cell volume. This study concluded that the extract has a promising anti-malarial activity which supports the in-vitro anti-plasmodial activity and the traditional use of the plant for treatment...
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Posted by admin on Feb 28, 2019 in |
Withania somnifera is a traditional indigenous plant having numerous medicinal values. With renewed interest, the present study was undertaken to determine its new potential therapeutic benefit. We aimed to evaluate the effect of methanolic extract of Withania somnifera leaves in L-methionine induced hyperhomocysteinemia in rats. Wistar rats (250-300 gm) were divided into 5 groups (n=6/group): Group I= Normal control (vehicle, 1% CMC); Group II= Hyperhomocysteinemic rats (L-methionine, 1 gm/kg, p.o.); Group III= Methanolic extract of Withania somnifera (200 mg/kg, p.o.); Group IV= Methanolic extract of Withania somnifera (400 mg/kg, p.o.); Group V= Folic acid (1 gm/kg, p.o.). All the rats except normal control group were treated with L-methionine for the induction of hyperhomocysteinemia. Animals of Group III-V were subjected to the respective treatment for 30 days. On completion of the study, serum homocysteine, cholesterol, triglyceride, LDL, VLDL, and HDL level were determined. Administration of L-methionine significantly increased the serum homocysteine, cholesterol, triglyceride, LDL, VLDL levels while decreased HDL level compared to normal control. Methanolic extract of Withania somnifera (200...
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Posted by admin on Feb 28, 2019 in |
The present study was undertaken to provide the rationale for the use of Terminalia bellirica as an anti-inflammatory agent using carrageenan-induced inflammation and antiulcer agent using ethanol-acid induced gastric mucosal injury model in the Swiss albino rats. The anti-inflammatory activity of the extract was evaluated using carrageenan (1% w/v) induced inflammation model at doses of 50, 120 and 300 mg/kg, p.o while using ibuprofen (20 mg/kg, p.o) as the standard drug. On the other hand, the antiulcer activity of methanolic extract of T. bellirica leaves at the doses of 100, 250 and 500 mg/kg, p.o. were examined against ethanol-acid induced gastric mucosal injury in the Swiss albino rats – keeping omeprazole (20 mg/kg, p.o.) as the reference. The rats were dissected, and their stomachs were macroscopically examined to identify hemorrhagic lesions in the glandular mucosa. Further, the histopathological changes of paws and stomachs were analyzed. T. bellirica significantly (P<0.01) decreased carrageenan-induced paw edema; it exhibited a reduction of 50.00%, 55.88% and 61.76% at doses of 50, 120 and 300 mg/kg respectively. The methanolic extract also...
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Posted by admin on Feb 28, 2019 in |
The plant Soymida febrifuga is called as Mamsaroyini in Sanskrit. It is an important medicinal plant belongs to family Meliaceae. This plant has got the traditional and ethnomedicinal significance. This is commonly used for Anti-inflammatory and also for joint pain, for cattle it is used for easy placental expulsion in the tribal areas of North-eastern Karnataka. Keeping its medicinal significance in a view, the present study is focused on phytochemical and pharmacognostic studies, and results show the presence of secondary metabolites such as phenols, flavonoids, triterpenes, lactones, tannins, saponins, alkaloids which in turn may be the responsible for its medicinal...
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