Posted by admin on Apr 30, 2019 in |
The plant Withania somnifera has many acclaimed medicinal uses. This work aims to explore the efficacy of the aqueous extract (AE) of W. somnifera on the isolated trachea and aorta rings, perfused heart, blood pressure and diuresis in rats. Phytochemical analysis of the whole plant of W. somnifera was carried out using standard extraction procedures followed by column chromatography. An aqueous extract (AE) was also prepared by boiling the whole plant material in water followed by evaporation under reduced pressure. The smooth muscle relaxant effect of AE of W. somnifera (10-4 – 3×10-1 mg/mL) was tested on isolated rat tracheal and aortic rings. The effect of AE on heart rate and contractility of the isolated perfused heart were recorded. The hypotensive effect of AE (0.4-120 mg/kg) was recorded from the carotid artery in anesthetized normotensive rats. The diuretic activity of AE was evaluated in rats at two different doses (800 and 1600 mg/kg), and urine volume was measured throughout 24 h. Phytochemical analysis of the Jordanian locality of W....
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Posted by admin on Apr 30, 2019 in |
The present investigation was directed to assess the counter lithiasis action of ethanolic concentrates of entire plant of Bryophyllum pinnatum. Urolithiasis is an infection brought about by the nearness and impacts of uroliths (stones) or calculi or exorbitant measures of precious stones in the urinary tract. The illness is alluded to by numerous names, including cystitis, urethritis, urinary calculi, bladder stones, or kidney stone. Ethanolic concentrate of the plant of Bryophyllum pinnatum was exposed to antilithiatic action in rodents where Ethylene glycol (0.75 (v/v)) utilized as the causing lithiasis specialist. A stamped ascend in calcium, oxalates, phosphorus, and creatinine in blood serum level saw in lithiasis (100 and 200 mg/kg) displayed a portion subordinate critical enemy of lithiasis action on treatment. The concentrate portion of 300 mg/kg likewise caused fractional instruction of calcium, oxalates, phosphorus, and creatinine in blood serum level the outcomes were discovered factual irrelevant. The antilithiatic impact of ethanol separate was discovered compelling with that reference...
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Posted by admin on Apr 30, 2019 in |
Aim: The present research aims to screen anabolic activity on bone formation and bone density in normal and Teriparatide (Rh PTH biosynthetic human parathyroid hormone 1-34) induced inhibition of osteogenesis in zebrafish larval model to alleviate osteoporosis and other bone and joint disease or disorders of the Nano encapsulated essential oil isolated from the Ruta graveolens (NELVORG) Family: Rutaceae using a novel, fast, economical and genetically tractable method for screening developmental aspects of bone formation in a high throughput fashion through the visualization of embryonic and larval skeleton of zebrafish (Danio rerio) model. Method: The volatile oil (VO) was isolated from the leaves of R. graveolens and extracted VO was subjected to GC-MS Analysis. The nano-encapsulated volatile oil of R. graveolens leaves (NELVORG) was prepared by solvent displacement method, and particle size was standardized by scanning electron microscope (SEM). We implemented 3Rs (Reduction, Replacement, Refinement) ethical principle to minimize harm to the vertebrate animals. Preliminary toxicological studies were evaluated on whole embryo and larvae, showed no mortality up to...
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Posted by admin on Mar 31, 2019 in |
Plants are a great source of medicines, which are useful in the treatment of various diseases. Today sophisticated modern research tools for evaluation of the plant drugs are available, but the microscopical evaluation method is one of the simplest and cheapest methods to start with for establishing the correct identity of the source materials. Ximenia americana of family Oleaceae have great medicinal value in Indian medicine. It is used in of medicine as febrifuge, diarrhea, jaundice, laxatives, mouthwashes and hepatoprotective. Ximenia americana Linn. leaves showed epidermis of the midrib is single layered and the epidermal cells are small, cubical, thick-walled, with the prominent cuticl presence of paracytic stomata, cyclocytic stomata Fig. 5 and absence of trichomes, under the polarized microscope, calcium oxalate appeared as druses and rosette type. In present study to evaluate microscopical characters of Ximenia americana leaf is carried out to lay down the standard which could be useful in future experimental...
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Posted by admin on Mar 31, 2019 in |
Piplartine is an amide obtained from Piper tuberculatum, which is promising in antiparasitic tests. Therefore, it has been used as the basis for the synthesis of new molecules. This study was designed to analyze the immunomodulatory effect of piplartine (A) and its derivative (B), in-vitro, on macrophages infected with Leihmania amazonensis, as well as the production of hydrogen peroxide (H2O2), nitric oxide (NO) and lipid bodies. Were evaluated by staining with giemsa and counting the cells under optical microscopy; labeling with tetramethyl benzidine and peroxidase type II; Greiss reagent and oil red, respectively, with amides A and B concentrations ranging from 0.0 to 64 μg/mL. Modulation of the immune system was observed. There was a decrease in the infection index at the highest concentration (64 μg/mL) for A and B in infected macrophages. Amide A (4 μg/mL) reduced the H2O2 production of infected macrophages by 99.3% compared to control. Cultures treated with A and B increases the NO production at 16 μg/mL and 0.25 μg/mL, respectively. The production of...
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