Posted by admin on Aug 31, 2019 in |
Growing burden of degenerative metabolic diseases can be addressed with help of traditional and folkloric medicine. The purpose of this study is to evaluate an ethanolic defatted extract (EDE) of Cipadessa baccifera (CB) leaf for anti-diabetic wound healing activity in male albino Wistar rats. The defatted and non-defatted extracts were prepared using water and ethanol solvent system. They were evaluated for pharmacognostic study, wound healing activity using animal excision and incision models. Antioxidant activity was performed using DPPH assay. Ascorbic acid was used as reference standard for determination of antioxidant activity. The antimicrobial activity was also carried out by disc diffusion and well diffusion method using chloramphenicol as reference standard. The EDE of leaf showed higher total phenolic content. It was found to be 389.2 mg gal/l. These extract showed good DPPH radical scavenging activity, which was found to be 68.75% in comparison with ascorbic acid. This extract also showed a good zone of inhibition with disc diffusion and well diffusion method. On 16th day, the 200 mg/kg EDE...
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Posted by admin on Aug 31, 2019 in |
Plants have a long history as therapeutic tools in the treatment of human diseases and have been used as a source of medicines for ages. In search of new biologically active natural products, many plants and herbs used in traditional medicine are screened for natural products with pharmacological activity. Qinghao is a traditional Chinese medicine prepared from the aerial parts of Artemisia annua L. which belongs to Compositae family. It is used as an anti-parasitic and fever relieving agent. Artemisinin was isolated from Qinghao as a major bioactive constituent and has been used to treat malaria. Besides artemisinin, the chemical constituents of Qinghao include volatile oil, terpenes, flavonoids, and coumarins. Scopoletin-derived sesquiterpene ethers Sesquiterpene derivatives of 7-hydroxy-6-methoxycoumarin (Scopoletin) are not so common. The aim of the study was to investigate chemical constituents present in the leaves of Artemisia annua after the commercial extraction process of the plant for artemisinin. From the preliminary studies, the compound identified was found to be a coumarin- Scopoletin. The residual leaves were used for...
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Posted by admin on Jul 31, 2019 in |
Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a verity of chemical substances used as a remedy for treating diseases. Anthelmintic and antioxidants have been treated with some medicinal plants or their extract based on folklore medicine. For the research Polygala chainensis and Cleome chelidonii selected based on its availability, high therapeutic value; activity has not been scientifically investigated. Very few pharmacological activities have been reported on whole plant of Polygala chainensis and Cleome chelidonii. The leaves of Cleome chelidonii and Polygala chinensis plants was observed for the phytochemical investigation and pharmacological evaluation. The percentage of yield and phytochemical was observed in methanolic extraction so this extraction was used for pharmacological activity. The extract of Cleome chelidonii and Polygala chinensis plants shown anthelmintic activity. The anthelmintic activity of Polygala chinensis was better than Cleome chelidonii. Significant...
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Posted by admin on Jun 30, 2019 in |
Two indigenous plants Clerodendrum colebrookianum walp and Centella asiatica Linn. were selected to determine its cardioprotective activity on male Wister albino rats. Empirical research was designed to evaluate the cardioprotective activity of the leaves of both with special reference to its putative protective role. Aqueous methanolic extracts of both the plants were prepared by continuous hot percolation method. Male albino rats of Wistar strain (250-300 g) were used for the study. Animals were divided into 10 groups of six animals each. Both pretreatment and post-treatment study was done for 16 days at two different doses of 300 mg/kg body weight and 700 mg/kg body weight, respectively. Carbon tetrachloride was used as a cardiotoxic agent. The in-vivo biological studies on serum and tissues of male Wister rats at the doses of 300 mg and 700 mg/kg body weight respectively was carried out taking silymarin as standard. The methanolic extract of both improved the cholesterol level along with significant improvement of SGPT (Serum glutamate pyruvate transaminase), SGOT (Serum glutamate oxaloacetate transaminase),...
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Posted by admin on Jun 30, 2019 in |
The present study was carried out to evaluate the wound healing potential of ethanolic flowers extract of Bauhinia acuminata in two different types of wound models in Albino rat viz., incision and excision, and compare the effects with standard drug povidine iodine ointment. The ethanolic extract at a dose of (250 mg/kg) possesses a significant increase in wound contraction and formation of scar in an excision wound model. The extract showed a significant increase in the breaking strength of resutured incision wound as compared to the control group (p<0.05). The result of the present study indicates that ethanolic flowers extract of B. acuminata posses significant wound healing in excision and incision wound model. The presence of phytoconstituents like flavonoids, saponins, phenols either individually or combined may exhibit the synergistic effect towards the healing of...
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