PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF POLYGALA CHAINENSIS, CLEOME CHELIDONIIAbstract
Natural products are an important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50% of all drugs in clinical use in the world. Herbal plants contain and produce a verity of chemical substances used as a remedy for treating diseases. Anthelmintic and antioxidants have been treated with some medicinal plants or their extract based on folklore medicine. For the research Polygala chainensis and Cleome chelidonii selected based on its availability, high therapeutic value; activity has not been scientifically investigated. Very few pharmacological activities have been reported on whole plant of Polygala chainensis and Cleome chelidonii. The leaves of Cleome chelidonii and Polygala chinensis plants was observed for the phytochemical investigation and pharmacological evaluation. The percentage of yield and phytochemical was observed in methanolic extraction so this extraction was used for pharmacological activity. The extract of Cleome chelidonii and Polygala chinensis plants shown anthelmintic activity. The anthelmintic activity of Polygala chinensis was better than Cleome chelidonii. Significant DPPH free radical scavenging activity was found in methanolic extract the extract of Cleome chelidoni IC50 value is 28.06 ± 1.01 µg/ml and Polygala chinensis IC value is 30.1 ± 1.01 µg/ml compare with reference standard ascorbic acid IC value is 44.7 ± 2.01 µg/ml. The methanolic extract of Polygala chinensis was beater than Cleome chelidonii for antioxidant activity.
N. V. Rekha *, S. K. Godasu, G. S. V. D. Jyothi and K. Hemanth
Sri Indu Institute of Pharmacy Sheriguda, Ibrahimpatnam, Hyderabad, Telangana, India.
10 July 2019
26 July 2019
29 July 2019
31 July 2019