Posted by admin on Jan 31, 2025 in |
Context: Epilepsy is a neurological disorder of brain in which the clusters of neurons, occasionally signal abnormally and cause strange emotions, sensations, and behavior, or sometimes muscle spasms, convulsions, and loss of consciousness. Lagenaria siceraria (Molina) Standley (LS), commonly known as “bottle gourd” (English), possesses several medicinal properties; little is known about its action as a nerve tonic. Objective: The purpose of this study was to characterize (or to study) the anti-epileptic potential of the bioactive fractions of methanolic extract of LS fruits through pharmacological screening. Materials and Methods: The experiment was conducted in specific animal models i.e., Pentylenetetrazole (PTZ)-induced convulsions and Maximal electroshock-induced seizures (MES) in Swiss albino mice to evaluate anti-epileptic effects. The effect of the fractions was also tested on motor coordination using the rota-rod apparatus. Results and Conclusions: Preliminary phytochemical screening of the methanolic extract of LS and its fractions showed a huge range of phytoactive compounds. Among all the fractions, chloroform and acetone fractions were found to have more number of such phytoactive compounds....
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Posted by admin on Jan 31, 2025 in |
Pharmacognostic study is important in laying down diagnostic parameters for standardization and authentication of plant materials in their fresh, dried or powdered state. Pharmacognostic study serves as a tool to identify adulterants and prevent substitution. Authentic plant material serves as raw material for herbal drug industry and local markets where people prefer folk medicine. Impatiens walleriana (Family – Balsaminaceae) is a folk medicine. Pharmacognostic studies on Impatiens walleriana species are not reported and our findings shall contribute to proper authentication of the plant material and also resolve the complexity associated with species having same common names as other species in the same genera. In the present study various parameters organoleptic, chemomicroscopic, macroscopic and microscopic characteristics have been studied in addition to fluorescence, physical and photochemical analysis. This study therefore generates resourceful data helping to identify Impatiens walleriana and guide researchers to explore therapeutic worthiness of this...
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Posted by admin on Jan 31, 2025 in |
To evaluate the Pharmacognostic properties, phytochemical screening, anthelmintic and anti-oxidant potential of the leaves of Euphorbia Hirta Linn. Microscopic and macroscopic characteristics of fresh and dried leaf samples were analysed. serial exhaustive extraction was done with various of solvents: Aqueous, Methanol, using Soxhlet apparatus. Physicochemical parameters such as moisture content, extractive values, ash content of leaf powder were also determined. The results revealed that the leaves extracts contain carbohydrates, alkaloids, steroids, Saponins, terpenoid, flavonoids etc., The results of anthelmintic study indicated that the methanolic and aqueous extracts significantly exhibited paralysis (P<0.01) in worms in lower doses (5, 10 and 15 mg/ml) and also caused death of worms especially at higher concentration of 15mg/ml, as compared to standard drug. These studies may be helpful for identification of Euphorbia Hirta Linn plant. This phytochemical may be responsible for the therapeutic activity of the plant. Further it useful for...
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Posted by admin on Dec 31, 2024 in |
Context: Obsessive-Compulsive disorder (OCD) is one of the most common neurological illness worldwide. Marble burying behavior in murine models is a unique and precise model for the assessment of anti-OCD like action of the tested drug. Lagenaria siceraria (Molina) Standley (LS), popularly known as “bottle gourd”, is a potent indigenous vegetable plant with high therapeutic value. Objective: The aim of this study was to evaluate the anti-OCD (anti-compulsive) effects of the methanolic extract of LS fruits (MLSF) and the phytosterol rich Chloroform fraction of methanolic extract of LS fruits (CFMLS) using the marble-burying test in mice. Materials and Methods: The screening of anti-OCD action was carried out on Swiss Albino mice. Moreover LC-MS/MS analysis was carried out for the isolation and identification of the bioactive phytoconstituents responsible for the anti-OCD like effect of CFMLS. Results and Conclusions: MLSF and CFMLS, at doses of 100, 200, and 400 mg/kg, p.o., decreased the total number of buried marbles in dose dependent manner. At dose of 400 mg/ kg, CFMLS exhibited the...
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Posted by admin on Dec 31, 2024 in |
Cynometra ananta belongs to the Fabaceae family and is a source of biologically active secondary metabolites. In West Africa, C. ananta is renowned for its empirical application against a range of illnesses. The phytochemical composition, total phenolic and flavonoid levels, and in-vitro antioxidant activity of extracts made from C. ananta trunk bark were all examined in this work. TLC was used to detect phenolic compounds and total flavonoids ; spectrophotometric techniques were used to quantify the total phenolic and flavonoid contents; and the DPPH test was used to measure the antioxidant activity of extracts from maceration and sonication. Sonication produced the greatest levels of total flavonoid (14 ±0.7 µg EQ/mg of dry matter) and phenolic (482 ± 4.8 µg GAE/mg of dry matter) contents. Moreover, with a 92% trapping rate, sonication displayed the highest DPPH activity. C. ananta trunk bark is a significant source of phenolic compounds and flavonoids. Trunk bark has demonstrated therapeutic benefits in conventional settings, making it a promising candidate for alternative...
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