Posted by admin on Oct 31, 2024 in |
In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including Bulk density, Tapped density, Angle of repose, Carr’s index, Hauser’s ratio, weight variation, hardness, friability, in-vitro dispersion time, drug content water absorption ratio, wetting time, in-vitro drug release. The tablet prepared by the direct compression method had a weight variation in the range of 198mg to 204mg which is below ±6.5%, Hardness of 3.7kg/cm2 to 4.3kg/cm2 , Percentage friability of 0.56% to 0.61%, in-vitro dispersion time of 18 sec to 24 sec, Wetting time of 33 sec to 51 sec and in-vitro drug release of 45.04% to 97.63% within 15 min. Fast dissolving tablets of metoprolol tartrate have enhanced dissolution and will lead to improved bioavailability and more effective therapy. The release rate of drugs from fast dissolving tablets intensifies with a rise in the concentration of super disintegrants and the metoprolol tartrate...
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Posted by admin on Oct 31, 2024 in |
The purpose of this work was to develop a novel topical formulation of econazole nitrate based on gel that can be easily scaled up in one pot for the potential treatment of fungal and yeast infections. Econazole nitrate is a topical antifungal, used to treat tinea versicolor, tinea pedis, and tinea cruris. Compared to applying cream or ointment, topical gels offer numerous advantages, one of which is that the drug is released more quickly to the intended site of action. A viscous mixture of propylene glycol, Triethanolamine, methyl paraben, and econazole nitrate were mixed together before being formulated into the optimized gel bases. The gel’s color, appearance, and homogeneity were assessed visually. For every formulation, the drug content, pH, viscosity, spreadability, and gel strength were characterized. The manufactured formulations were transparent, half white, pale yellow, and exhibited excellent homogeneity. The pH and viscosity are within the limit. The drug diffusion of F1 93.81, F2 97.56, F3 92.36, F4 90.95, F5 93.18 and F6 90.14. From among all the developed...
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Posted by admin on Oct 10, 2024 in |
Phytochemicals are plant-derived bioactive substances that are extensively used in conventional herbal treatment. The locals employ these herbal remedies to treat a wide range of illnesses, including serious conditions like diabetes mellitus, cancer, HIV and others. The current study’s goals were to screen for these phytochemicals and assess the antibacterial efficacy of methanolic and ethanolic extracts from Portulaca oleracea and study of antibacterial activity of leaf extracts from Portulaca...
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Posted by admin on Oct 10, 2024 in |
This study aims to shed light on the plant Ecballium elaterium (L.) A. Rich., Flora of Palestine, which belongs to the Cucurbitaceae family, in terms of the chemical composition of its leaves, flowers, fruits, seeds, and roots. The chemical study of various extracts from leaves flowers, seeds, fruits and roots from Ecballium elaterium (L.) A. Rich. for biologically active compounds was carried out using multiple types of specific chemical reactions and multiple types of chromatographs. As a result of chemical examination of biologically active compounds from members of the Ecballium elaterium plant, which is widespread in Palestine, the presence of the following active substances was proven for the first time: triterpenoids, alkaloids, tannins, phenols, flavonoids, and amino...
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Posted by admin on Oct 10, 2024 in |
Chitosan, a biopolymer derived from chitin, has garnered significant attention due to its unique properties, eco-friendly nature, and diverse applications in various industries owing to its remarkable properties. This study focuses on the extraction and characterization of chitosan from giant African snail shells. Various experiments were designed to optimize the extraction process, resulting in a chitosan yield of 61.37%, a moisture content of 2.02%, and a degree of deacetylation (DD) of 68.24%. The physicochemical properties of the extracted chitosan nanoparticles were characterized, revealing important parameters for its potential applications. Fourier Transform Infrared Spectroscopy (FTIRS) analysis indicated the presence of functional groups such as O-H, N-H, C≡C, C=C, and N-H bending, corroborating previous studies. Scanning Electron Microscopy (SEM) revealed the chitosan particles’ polygonal shape and rough surface, suggesting their suitability for adsorption applications and heavy metal trapping. X-ray Diffraction (XRD) analysis demonstrated a semi-crystalline nature of the chitosan, with a sharp peak at 34° (2θ) and other suppressed peaks. These findings confirm the successful synthesis of chitosan from giant African...
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