Posted by admin on Nov 30, 2023 in |
Background: Malnutrition in form of protein energy malnourishment, is a range of pathological conditions arising from coincident lack of protein and/or energy in varying proportions which can results in muscle wasting and degeneration. Aim: The study is aimed to investigate the effects of defatted Moringa oleifera seed on skeletal muscle of Protein Energy Malnourished rats and to assess its effect on enzyme markers: AST, ALT, Total protein, Albumin, Ca2+ ATPase and Na+/K+ ATPase. Methods: 16 white albino rats of waster strain (Rattus novergicus) were initially divided into ‘A’ and ‘B’ groups; Group A rats served as positive control and was administered normal growers’ feed while Group ‘B’ rats were administered with low protein based diet to induce muscle wasting for 21 days. After the period of malnourishment, group B was further divided into 3 groups: C, D, E. Group C was sacrificed which served as negative control while group D and E were fed with recovery diet containing 20% M. oleifera based diet and 20% fish meal based diet...
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Posted by admin on Feb 28, 2022 in |
Aim: The objective of the present review is to compile & explore published literature on ethno botanical uses, pharmacognostic studies, phytochemicals, and pharmacological activities of Stachytarpheta jamaicensis (L.) Vahl from 2016 to till date. Background: Stachytarpheta jamaicensis (L.) Vahl, an under shrub belongs to the family Verbenaceae. The plant is native to the tropical Americas and has been used traditionally by various ethnic groups of this region. Though regarded as a weed or invasive species in many parts of the world, research works report the plant being used for medicinal purposes, as animal feed and as ornamental or hedge plant. Material & Methods: The review was undertaken by literature search through electronic databases such as PubMed and Google scholar, reported from 2016 to till date. Review results: The different parts of the plant are used in various ailments like fever, skin diseases, diabetes and respiratory problems. Flavonoid, tannins, saponins, glycosides are the chief bioactive constituents reported to be present which are responsible for several pharmacological activities. Pharmacological studies report...
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Posted by admin on Oct 31, 2018 in |
The optimization of aqueous and non-aqueous solubility of a drug or a drug-like molecule can be examined via the Aspen Plus simulation platform. Paracetamol (solute) will be taken as a case study. The following solvents were used in our dry (virtual) lab experiment: water, paracetamol (PARACTML), used as a solid solute, Di-Ethylene-Glycol (DEG), 1,2-Propanediol (PROPGLYC), and Poly-Ethylene-Glycol (PEG). A simplified flow sheet made of a single mixing tank where it has three feed streams, representing the solute, the water, and the set of organic solvents and one product stream where paracetamol is solubilized (liquid solution). Three different objective functions were used: Minimization of both the molar Gibbs free energy of mixing, ∆Gmix, and the molar Gibbs free energy of the mixture, Gmix, and maximization of the mass solubility of paracetamol in solution, expressed in g/L. The NRTL property method was used to analyze the solution properties. Using the molar Gibbs free energy, Gmix, as a criterion of solution thermodynamic stability, it was found that a binary non-aqueous mixture made...
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Posted by admin on Jun 30, 2018 in |
The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study, we have isolated three compounds (LC1-3) by chromatographic methods from the mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as Kaempferol-3, 7-di-O-α-L-rhamnopyranoside (LC1), 7, 4’- dihydroxy-5, 3’- dimethoxyflavone (LC2), (S)-5, 5’, 7-trihydroxy-2’, 4’-dimethoxy-6-methylflavanone (LC3). Their structures were elucidated by spectroscopic methods, including MS and NMR. Compound LC3 was isolated from mulberry leaves for the first time. These compounds were evaluated the tyrosinase inhibitory activity in-vitro. Our data showed that compound LC3 has potential tyrosinase inhibitory effects with IC50 values of 15.48 ± 2.96...
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Posted by admin on Mar 15, 2018 in |
This study was aimed to maximize the benefits of the use of by-products (oil cake) of olive fruits and black seeds after extraction of their fixed oils, rather than their use as animals feed or landfilling or composting. The cake of both seeds was assessed by HPLC for their main bioactive marker compounds (thymoquinone for black seed and oleuropein for olive fruit), to choose the best method for extraction, determination of phenolic contents and in vitro antioxidant activity (DPPH and reducing powers, FRAP assays). Both by-products were also assessed for their cytotoxicity against four human breast cell lines, three of them are cancerous (MCF7, MDA-MB-213, Vcr-R), and a non-cancerous one (epithelial type) but immortalized by telomerase (hTERT-HME), in addition to a human hepatoma cell line (HepG2). Also, both wastes were subjected for in-vitro CDC25s phosphatase inhibition assay on three isoforms (A-C) and for in-vivo immunomodulatory effects. In conclusion, the results of this study showed the interest of cumulating different biological approaches exploring various physiological mechanisms and showed the utility...
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