Posted by admin on Nov 30, 2017 in |
Aqueous and ethanol ethyl acetate chloroform-methanol extracts from the leaves of Ricinus communis were investigated for their anthelmintic activity against Pheretima posthuma and three concentrations (50, 75 and 100 mg/ml) of each extract were studied for activity, in which paralysis and death time of the worm. Both the extract exhibited remarkable anthelminthic activity at all three concentrations. Albendazole suspension is used as standard reference (20 mg/ml) and distilled water as control. Therefore the aqueous and ethanol methanol extract of leaves of Ricinus communis has been demonstrated for the first...
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Posted by admin on Nov 30, 2017 in |
Background: There are very less therapeutic and reliable liver protective drugs in modern medicine to prevent and treat the liver injury caused due to drugs. Traditionally Solanum xanthocarpum Schradt. (SX) and Wendl. and Juniperus communis Linn. (JC) have been used since long for their hepatoprotective effect. The current study was carried out to explore the hepatoprotective role of SX and JC against liver toxicity in rodents induced by carbon tetrachloride (CCl4). Materials and Methods: The antioxidant potential of hydroalcoholic extract of SX and JC were investigated by using established DPPH in-vitro assay method. The hydroalcoholic extract of SX and JC at doses (200 and 400 mg/kg b.w.) were studied for their liver protective activity against hepatic damage induced by CCl4 in Wistar rats. An assay of the oxidative stress parameters, alkaline phosphatase, transaminase, total bilirubin, albumin and liver histopathology were performed to evaluate the hepatoprotective activity of SX and JC. The assay results were introduced as the standard error ofthe mean (SEM) for each group. Results: The ethanolic extract...
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Posted by admin on Nov 30, 2017 in |
The anti-inflammatory and antioxidant activities of the methanol extract of Amomum masticatorium rhizome were observed in various experimental models. Phytochemical constituents like phenols and flavonoids were also estimated. The antioxidant activity was evaluated by DPPH and superoxide radical scavenging assays. The extract showed significant antioxidant activity. The in-vitro anti-inflammatory activity of the extract was investigated by various methods viz. albumin denaturation, membrane stabilization, and proteinase inhibitory assays. Results showed that the extract exhibited significant anti-inflammatory activity by inhibiting the heat-induced albumin denaturation with IC50 value 34.15 ± 0.404µg/ml, effectively stabilized RBC membrane with an IC50 value of 51.47 ± 1.56 µg/ml and significantly inhibited proteinase activity with an IC50 value of 52.8 ± 0.61µg/ml. In-vivo activity was evaluated in carrageenan and formalin-induced paw edema test in mice and compared with that of standard drug diclofenac. In both models, the extract showed a significant reduction in edema. The extract at 200 mg/kg b. wt showed a significant reduction in carrageenan-induced paw edema at a 3rd h and chronic edema on...
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Posted by admin on Nov 30, 2017 in |
The extracts of two different plant were screened for their phenols, flavonoid and antioxidant activity by DPPH method for two locations. In this study seed oil and defatted seed cake extracts of M. azedarach and P. pinnata from two locations indicate high phenolics (13.5-51.2 mgGAE/g) and flavonoids content (1.5-4.2 mgCAE/g). The IC50 value was (0.032-0.048...
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Posted by admin on Nov 30, 2017 in |
The aim of the present study is to evaluate the anti anemic activity of ethanolic leaf extract of Corchorus fascicularis against phenylhydrazine-induced hemolytic anemia in rats. Phenylhydrazine (40mg/kg) was administered intraperitoneally for 2 days to induce anemia in rats. The animals were divided into five groups of 6 animals each. Group I served as normal control, group II as anemic control, group III as reference control administered with vitamin B12 and group IV and V animals were treated with 100 mg/kg and 200mg/kg of ethanolic leaf extract of Corchorus fascicularis Linn. (CFE). All the test drugs were administered once daily for 28 days through the oral route. On 1st, 14th and 28th-day blood were withdrawn, through sinus puncture under phenobarbitone anesthesia and subjected to the estimation of RBC, Hb and percentage Hematocrit. Both the ethanolic leaf extracts of Corchorus fascicularis Linn. and vitamin B12 significantly increased the RBC, Hb and Hematocrit levels which conclude that Corchorus fascicularis Linn. leaf extract exhibits anti-anemic...
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