PROTECTIVE EFFECTS OF ETHANOLIC LEAF EXTRACTS OF CORCHORUS FASCICULARIS IN PHENYLHYDRAZINE INDUCED ANEMIC RATSAbstract
The aim of the present study is to evaluate the anti anemic activity of ethanolic leaf extract of Corchorus fascicularis against phenylhydrazine-induced hemolytic anemia in rats. Phenylhydrazine (40mg/kg) was administered intraperitoneally for 2 days to induce anemia in rats. The animals were divided into five groups of 6 animals each. Group I served as normal control, group II as anemic control, group III as reference control administered with vitamin B12 and group IV and V animals were treated with 100 mg/kg and 200mg/kg of ethanolic leaf extract of Corchorus fascicularis Linn. (CFE). All the test drugs were administered once daily for 28 days through the oral route. On 1st, 14th and 28th-day blood were withdrawn, through sinus puncture under phenobarbitone anesthesia and subjected to the estimation of RBC, Hb and percentage Hematocrit. Both the ethanolic leaf extracts of Corchorus fascicularis Linn. and vitamin B12 significantly increased the RBC, Hb and Hematocrit levels which conclude that Corchorus fascicularis Linn. leaf extract exhibits anti-anemic activity.
V. S. Shende *, F. H. Shaikh, S. K. Medhekar and A. B. Chincholkar
Satara College of Pharmacy, Satara, Maharashtra, India.
19 June 2017
12 September 2017
17 September 2017
01 December 2017