Posted by admin on Jul 31, 2021 in |
Hydroxycinnamic acids (HCA) and derivatives are well-known phenolic compounds ubiquitous in plants, showing relevant antioxidant properties as well as cytotoxicity toward several tumor cell lines. They can inhibit cell growth in a manner strongly dependent on their structural properties. Caffeic acid (CA) is one of the most widely distributed hydroxycinnamate and phenylpropanoid metabolites in plant tissues and agricultural wastes. Caffeic acid and its esters have a variety of biological activities, including antimicrobial, antioxidant, anti-inflammatory, anticancer, antiviral, anti-diabetic, anti-HIV, anti-influenza and antimalarial activities. In most cases, the synthesis of alkyl esters can significantly improve their function. This review is an overview of the available information about the chemical synthesis, anticancer and anti-inflammatory activities of caffeic acid esters. Considering the relevance of these compounds in human health, many of them have been the focus of reviews, taking as a center their obtaining from the plants. There are few revisions that compile the chemical synthesis methods, in this way, we consider that this review does an important...
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Posted by admin on Jul 31, 2021 in |
Pterospermum acerifolium belonging to Sterculiaceae family, commonly known as Bayur Tree, Dinner-plate tree is well distributed in India, particularly in the sub-Himalayan zone and outer Himalayan valleys. It is commonly known as Kanakchampa or Muchukunda. Different parts of the tree have been used to treat many diseases for thousands of years in traditional medicine. Mainly it is used for earache, smallpox, leprosy, inflammation, ulcers, diabetes syndrome, constipation, ascites, abdominal pain, urinary discharge, wound healing, immunosuppressive, hepatoprotective, antihelmintic, antimitotic, anticancer activity. The descriptions of morphology, vernacular names, taxonomy, pharmacological activities, chemical constituents, ethnobotanical use, therapeutic use are richly found in Ayurvedic and contemporary literature. The review article will help the researchers to explore more about the said plant for the larger benefit of...
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Posted by admin on Jul 31, 2021 in |
A good number of medicinal and aromatic plants are used as complementary and alternative medicine in different regions of Nigeria. However, some of this valuable ethnobotanical knowledge has not been formally documented. Hence, the objective of this study was to document the ethnomedicinal plants, their preparations, and applications in managing a variety of ailments in the Oju local government area of Benue State, Nigeria. Twenty-three traditional healers (16 male and 7 female) of different ages (42–75 years) were purposively and randomly selected with the help of administrative personnel in collecting the plant species. A key informant interview guide was used to collect the data. Thirty-three plants species belonging to 26 families were collected and documented. Of the 33 species, 55% were trees, 21% shrubs, 21% herbs, and 3% climbers. Leaves were the most utilized plant part. The routes of administration are mainly internal, in which oral administration is the common one. A total of 23 different prescriptions for the individual plant and in combination were recorded for their healing...
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Posted by admin on Jul 31, 2021 in |
The discovery of drugs for Alzheimer’s disease (AD) therapy that can also permeate the blood-brain barrier (BBB) is very difficult owing to its specificity and restrictive nature. The BBB disruption or drug administration directly into the brain is not an option due to toxic effects and low diffusion of the therapeutic molecule in the brain parenchyma. A promising approach for systemic drug delivery to the central nervous system is the use of nanosized carriers. The therapeutic potential of certain nanopharmaceuticals for AD has already been demonstrated in-vivo after systemic delivery. Herbosomes have an enhanced absorption rate, producing excellent bio-availability, good penetration power. Herbosome technology is one of such systems that incorporate phospholipids into standardized active ingredients of herbal extracts, thus effectively enhancing the bioavailability of water-soluble bioactive constituents of phytomedicines such as flavonoids, phenolics and hydrophilic compounds. These phytoconstituents have been established to exhibit a variety of biological activities that have pharmacological benefits. However, poor absorption of these phytoconstituents limits their bioavailability. The poor absorption is principally due to...
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Posted by admin on Jul 31, 2021 in |
The demand for today’s chemistry is finding an efficient alternative to synthetic indicators. Acid-base titration was conducted using natural indicators in the present research work. The natural indicator is prepared from Jasminum sambac, the most commonly occurring plant. The ethanolic flower extract was used as a natural indicator. For acid-base titration, Hydrochloric acid (HCl) as strong acid and Acetic acid (CH3COOH) used as a weak acid, and Sodium hydroxide (NaOH) were chosen as a strong base. Successful results were achieved when it was examined by using standard synthetic indicators. Titration shows colour change at the point of equivalence. Thus, for acid-base titration at any dilution, natural indicators from flowers can be used. Titration with natural indicator from ethanolic flower extract of Jasminum sambac has not yet been performed by any research team. It is very simple and economical to use ethanolic flower extract of Jasminum sambac as an indicator as it provides the same outcome accuracy as that provided by the synthetic...
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