Posted by admin on Aug 24, 2016 in |
Plant oils have been used for a variety of purposes for many thousands of years. In particular, the anti-microbial & anti-fungal activity of plant extracts and oils have formed the basis of many applications. Since, Aspergillus niger contamination in leather and leather apparels reduces the export value considerably, demand an appropriate solution. The present study emphasizes the anti-Aspergillus potential of an essential oil and microsphere formulation in combating the A. niger growth in finished leather. A. niger ATCC 16888 strain was chosen for the present study. Both well diffusion and broth dilution methods are used. Mode of action and microsphere formulation and its impact on leather studied using standard protocols. Essential oil (EO) of Acorus calamus L. exhibited appreciable Anti-Aspergillus potency compared to untreated control and standard drugs (Itraconazole & Voriconazole). The oil contains components in addition to asarone. The damage in the plasma membrane and reduction in ergosterol content authenticate the antifungal action EO. The new microsphere formulation of an essential oil appreciably prevent the growth of A....
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Posted by admin on Aug 24, 2016 in |
Diabetes mellitus (DM) is a serious metabolic disease which has several complications including diabetic nephropathy, coronary heart disease, and hypertension. It has been estimated that by the year 2010, the prevalence of DM worldwide will reach approximately 240 million. Despite considerable progress in the management of diabetes mellitus by synthetic drugs, the search for indigenous and diabetic agents continues. Natural product based compounds and there analogs thereof from various medicinal plants have provided numerous clinically useful drugs. In this review article, we mainly focused on neem (Azadirachta indica), the most useful traditional plant in India that has been explored towards an antidiabetic...
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Posted by admin on Aug 13, 2015 in |
Introduction: The phytochemicals in medicinal plants are defined as bioactive non-nutrient plant compounds in fruits, vegetables, and grains that have been linked to reducing the risk of major chronic diseases. The medicinal plant is promising to have such have effective medicinal property due to the presence of phytochemical compounds like alkaloids, tannins, flavonoids, and phenolic compounds. The present study aimed to find the phytochemicals present in hexane and ethyl acetate extracts of Justicia tranqubarieansis and Bauhinia racemosa and also find out the antioxidant property of these plant extracts. Methods: Chemical methods identified phytochemicals present in the hexane and ethyl acetate extract of Justicia tranqubarieansis and Bauhinia racemosa. The antioxidant property was done by DPPH free radical scavenging method. Results: In Justicia tranqubarieansis, hexane extract showed positive for flavonoids, alkaloids, and coumarins. Ethyl acetate extract showed positive for flavonoids, alkaloids, cardiac glycosides, terpenoids, coumarins, and steroids. The hexane extract of Bauhinia racemosa showed positive for flavonoids, alkaloids, quinines, cardiac glycosides, terpenoids, and coumarins. Ethyl acetate extract showed positive for flavonoids,...
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Posted by admin on Aug 13, 2015 in |
Antioxidants play an essential role in the inhibition of the oxidative damage of the biomolecules. Flavonoids are known as potent antioxidants and are present in abundance in many of the fruits and vegetables besides being present in a large number of medicinal botanicals. A quantitative analysis of the antioxidant activity of quercetin, luteolin, kaempherol and taxifolin belonging to the flavonoid class of compounds, has been obtained by the determination of the structures, energetics and global reactivity descriptors in both neutral and charged states using Density Functional Theory. A comparison of the antioxidant property of these flavonoids, with those of the vitamins viz. vitamin A and vitamin E molecules, reveals that these flavonoid molecules are better candidates for electronic charge transfer to the ROS and hence possesses greater antioxidant activity. To probe the preferred site of reactivity, the Fukui function; fk- was also evaluated for each of these antioxidant molecules. The trends observed in various reactivity descriptors along with Fukui indices indicates that the substitution of B-ring and the C2-C3...
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Posted by admin on Aug 13, 2015 in |
The purpose of this research work was to develop and evaluate matrix-type transdermal patches of Ketoprofen. Employing different ratios of hydrophilic and hydrophobic polymers by a solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by Infrared Spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Seven formulations (Consisting of hydroxypropyl methylcellulose E5 and ethylcellulose in the ratios of10:0, 0:10, 1:9, 2:8, 3:7, 4:6, 5:5 (F1, F2, F3, F4, F5, F6, F7) were prepared. All formulations carried dimethyl sulfoxide as a penetration enhancer and dibutyl phthalate as a plasticizer in chloroform and methanol (1:1) as the solvent system. The prepared TDDS were evaluated for in-vitro release, moisture absorption, moisture loss, and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. Patch coded as F1 (HPMC alone) showed maximum release of 95.526 ± 0.982% in 8 h, whereas F2 (EC alone) showed maximum release of 67.078 ± 1.875% in 24 h and combination of polymers F7 (5:5)...
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