Posted by admin on Dec 31, 2020 in |
Cervical cancer is a highly prevalent global disease among females and currently available treatments are nevertheless restricted and have substantial adverse effects. Plants may be a rich source of molecules with therapeutic potentials, such as Campomanesia aureas O. Berg, Myrtaceae, a native species from the South of Brazil with few data regarding its biological effects. In this study, we investigated the chemical composition and antineoplastic potential in-vitro of the essential oil (EO) of C. aureas leaves in human cervical cancer cells (SiHa), as well as its effect in the viability of non-tumoral cells (HaCat). CG-MS analysis reveals that the EO is rich in oxygenated sesquiterpenes and monoterpenes and MTT colorimetric assay shows that it significantly inhibits the viability of the SiHa cell line at different concentrations. Besides, the EO reduced the colony-forming capacity of the tumor cell line, and the ratio between the IC50 values of cell lines demonstrated a promising selectivity index for C. aurea EO. Therefore, the EO could be a potential source of new anticancer...
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Posted by admin on Dec 31, 2020 in |
Objective: The aim of this study was to evaluate the anticancer activity of a series of six structurally related [1, 4]-Benzoquinone monooximes and to investigate structure-activity relationships (SAR) of these compounds. Materials and Method: The mono-oximes obtained by oximination of para-benzoquinones 1-4 had their structures confirmed by ¹H NMR, 13C NMR. The cytotoxic study was assessed by the MTT assay on three tumor cell lines: HL60 (promyelocytic leukemia), NCI-H292 (lung cancer), and MCF-7 (breast adenocarcinoma). Results: Six oximes were synthetized 2 – methyl-[1,4]-benzoquinone oxime tosylate (I), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime tosylate (II), 5-isopropyl-5-mehyl-[1,4]-benzoquinone oxime tosylate (III), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime (IV), 2,5-dimethyl-[1,4]-benzoquinone oxime tosylate (V), 2-methyl-[1,4]-benzoquinone oxime tosylate (VI). Compounds II to V showed significant activity against all cell lines; while compound I and VI presented low or no activity. Conclusion: These experimental data lead to the conclusion that oximes (II –V) may be used as potential starting structures for the design of novel anticancer...
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Posted by admin on Dec 31, 2019 in |
To analyze the efficacy of topical nepafenac, 0.1% eye drops in the treatment of diabetic macular edema (DME). Method: a prospective interventional study in 14 eyes having center involving DME were taken into consideration. They were administered topical nepafenac eye drops 0.1% thrice daily for 6 months. Their vision and foveal thickness were recorded systematically at the start of the treatment and then at 2nd, 4th, and 6th month follow up. Results: The mean baseline and final Log MAR visual acuity were 0.33 and 0.15, respectively and the mean baseline and final foveal thickness were 450 µm and 290 µm respectively. Conclusion: A statistically significant improvement was noticed in the visual acuity and foveal thickness after the administration of 0.1% of topical nepafenac eye...
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Posted by admin on Dec 31, 2019 in |
Natural compounds have already contributed to the discovery of new anti-malarial drugs. Atovaquone, artemisinin and its semi-synthetic derivatives as well as clindamycin, erythromycin, azithromycin, chlortetracycline, tetracycline, oxytetracycline and doxycycline, are noteworthy examples of the varied contribution of natural products for the development of effective anti-malarial drugs, particularly valuable for the treatment of chloroquine-resistant parasites. To avoid side effects and the resistance developed by the synthetic drug natural drug preffered. However, in many cases good activity and selectivity were observed. Most importantly, several compounds containing unique structural composition have been isolated and characterized. In the present review, a number of potential anti-malarial plants explored have been brought out, and a number of leads suggested on the basis of their anti-malarial activities. Thus, it provides guidance for areas of further research on potential plant resources that could be sources of compounds with therapeutic properties for the treatment of malaria. Some of the plants were investigated for anti-malarial activities, and their efficacy, toxicity, and safety aspects still need to be...
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Posted by admin on Dec 31, 2019 in |
Herbs are used as a source of medicine in Ayurveda and also in some traditional systems of medicine as having lesser side effects and cost when compared with synthetic drugs. Plants live on a planet with days and seasons, and that affects their phytoconstituents. The availability of active principles in medicinal plants changes by seasonal fluctuations, so their dose pattern for therapeutic efficacy also gets influenced. The best duration for the harvesting of specific secondary metabolites for better yield is not fixed. Seasonal impact show changes in important constituents like polyphenol, flavonoids, glycosides, alkaloids, and essential oil. Late summer is the best collection time for essential oil components. Winter is the best season for the harvesting of secondary metabolites containing plant parts. The results of these studies may help the researcher those who are involved in exploring the isolation of valuable chemicals from the plants for the treatment of various diseases. Therefore, the current review aims to focus on the best possible season for the harvesting of pharmaceutically important...
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