Posted by admin on Oct 31, 2018 in |
In folk medicine, Gendarussa vulgaris Nees (Acanthaceae) is used for the treatment of pain, fever, asthma, rheumatism, colic’s, arthritis, jaundice, inflammation, cephalgia, eczema, diarrhea, wounds, dyspepsia. The present study was designed to evaluate for its safety as well as anti-inflammatory and neuro-pharmacological activities of ethyl acetate extract of Gendarussa vulgaris leaves (EAGVL) by using OECD guidelines, xylene-induced ear edema in mice, pentobarbital-induced sleeping test, open field, and hole cross test. Mortality, a sign of any toxicity or behavioral changes were not observed up to the dose as high as 4000 mg/kg. The crude extract was found to have significant (P<0.05, vs. control) anti-inflammatory activity at the oral dose of 200 mg/kg and 400 mg/kg (b.wt.) in the tested animals. Moreover, the extract of Gendarussa vulgaris leaves potentiated the pentobarbital-induced sleeping time in mice at dose 200 mg/kg and 400 mg/kg. In open field test, the extract at dose 200 mg/kg and 400 mg/kg showed a significant (P<0.05, vs. control) depressant and slight anti-depressant activity. Again, both lower and higher...
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Posted by admin on Oct 31, 2018 in |
Antioxidant potential, phytochemical and growth inhibitory characteristics of Anthocleista vogelii stem bark (AVSB) and root (AVRT), Annona senegalensis stem bark (ANSB) and Waltheria indica leaf (WILV) aqueous extracts were evaluated. Phytochemical analysis showed the presence of flavonoids, tannins, saponins, sterols, alkaloids, and terpenes. Fourier Transform Infra-Red (FT-IR) analyses indicated the presence of O-H, C-H, C=O, C=C, N-H and C-O bonds. AVSB, AVRT, ANSB, and WILV significantly (P<0.001) and dose-dependently (1-32 mg/mL) inhibited Sorghum bicolor seed radicle growth throughout 24-72 h compared with the control seeds. This result indicated the propensity of Anthocleista vogelii (stem bark and root), Annona senegalensis (stem bark) and Waltheria indica (leaf) extracts to inhibit the proliferation of fast-growing cells. The presence of the phytochemicals and the inhibitory activity of the extracts provided a preliminary indication of their cytotoxicity and potential for the management of...
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Posted by admin on Nov 13, 2017 in |
Vitamins are essential components of any diet and diet deficient in vitamins is the prime reason for malnutrition. In the present investigation, essential oil fractions isolated from foliages and tender shoots of few Apiaceae members commonly used as spices, vegetable, and flavoring agents were involved in phytochemical diversity analysis. GC-MS fingerprinting of the essential oil fractions isolated from young foliages and tender stems showed the presence of vitamin E and K in appreciable quantity. The foliage of carrot (Daucus carota L.), a popular winter vegetable is very rich in α-Tocopherol and phytonadione. Tender shoot portion of ajwain (Trachyspermum ammi Sprague, a common spice yielding member and coriander (Coriandrum sativum Linn.) also have a significant amount of α-Tocopherol and phytonadione. The study has indicated the supplementary use of these members as a potential source of vitamin E and K beside their common...
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Posted by admin on Nov 13, 2017 in |
Heterophragma quadriloculare (Roxb.) K. Schum. (HQ) belongs to Bignoneace family and known as Warras. Usage of HQ plant in diabetes has been claimed traditionally, but scientific documentation is not yet available. So, it was our interest to develop a scientific database for HQ leaves. HQ leaves were studied for its traditional claim of anti-diabetic activity by oral glucose tolerance test (OGTT) model using normal rats. All possible phytoconstituents were extracted into a selected range of solvents based on its polarity, i.e., petroleum ether, chloroform, methanol, water. The extracts were screened for OGTT at a dose level of 200 and 400 mg/kg per oral. In OGTT study through all extracts found to reduce blood glucose level, petroleum ether extract and chloroform extract showed dose-dependent activity. These results provided the clue for the presence of anti-diabetic constituents in petroleum ether extract. Thus petroleum ether extract (200 mg/kg), an unsaponifiable fraction of petroleum ether extract (100 mg/kg) and a saponifiable fraction of petroleum ether extract (100 mg/kg) of HQ were studied in...
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Posted by admin on Nov 13, 2017 in |
Natural products from plants are rich sources of chemical diversity and most of the pharmacologically active principles currently used as drugs, including anticancer agents are plant products. The present study aims at phytochemical screening and evaluation of the anticancer potential of methanolic extract of Garcinia indica fruit rinds belonging to Family Clusiaceae. The methanolic extract of dried Fruit rinds of Garcinia indica was subjected to the phytochemical tests to confirm the presence of Carbohydrate, alkaloids, steroids, Glycosides, flavonoids, Tannic acid and phenolic compounds, proteins, and fixed oils. In-vitro antioxidant activity of the extract was assayed using DPPH radical scavenging assay, hydrogen peroxide scavenging activity, reducing power activity. Total phenol and flavonoid contents were determined and expressed in gallic acid and catechin equivalent respectively. The results of the study indicate that the methanolic extracts of the Garcinia indica fruit rind possess significant scavenging activity against DPPH (78.1 μg/ml), reducing power activity (0.387 absorbances at 100 μg/ml) free radical scavenging activity (44.64 μg/ml). The free radical scavenging and promising antioxidant activities...
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